Results 201 to 210 of about 19,799 (257)

The Clinical Significance of Platelet Membrane Glycoproteins

Hematology/Oncology Clinics of North America, 1990
To mediate their hemostatic functions, platelets must adhere to exposed vascular subendothelium and then aggregate. A variety of membrane glycoprotein receptors for adhesive ligands are present on platelets that promote adhesion and aggregation. Analysis of congenital disorders of platelet glycoproteins has been instrumental in clarifying our knowledge
Rodger Mcever
exaly   +3 more sources

Platelet Membrane Glycoproteins: Functions in Cellular Interactions

Annual Review of Cell Biology, 1990
The understanding of the structure and function of platelet membrane glycoproteins has been facilitated by studies showing that they belong to larger gene families of cell surface receptors involved in cellular interactions. In some instances (e.g. GP IIb-IIIa and GP Ib-IX) the study of the platelet proteins has served as a prototype for relatively ...
N Kieffer
exaly   +3 more sources

Thrombosis and Thrombolysis: Platelet Membrane Glycoproteins

Heart Lung and Circulation, 2007
Over the last quarter of a century, therapy for acute coronary syndromes has rapidly evolved. The major causative factor for acute coronary syndromes, particularly acute myocardial infarction, is now recognised to be coronary thrombosis and therapies using thrombolytic agents to dissolve thrombus or percutaneous coronary interventions (angioplasty and ...
exaly   +3 more sources

Expression of platelet parameters and platelet membrane glycoproteins in childhood Burkitt lymphoma

Leukemia Research, 2019
Platelet activation and functional changes in some haematological malignancies have been investigated with little or no known documentation on Burkitt lymphoma (BL). Abnormalities of platelets contribute to either haemorrhage or thrombotic episodes which are life-threatening in patients with BL.
Otchere Addai-Mensah   +2 more
exaly   +3 more sources

Platelet membrane glycoproteins

Thrombosis Research, 1996
Inherited giant platelet disorders (IGPD) are a heterogeneous group of rare diseases characterized by thrombocytopenia, large platelets and variable bleeding symptoms. Glycoprotein (GP) expression on platelet surface in these conditions is poorly characterized. We have investigated the expression of constitutively expressed platelet membrane GP and the
Sílvia, Pérez-Pujol   +5 more
openaire   +3 more sources

Membrane Glycoproteins in Cryopreserved Platelets

Vox Sanguinis, 1994
AbstractAlthough platelets stored by cryopreservation are effective in hemostasis, they acquire a number of functional defects during storage and preparation for transfusion. In addition to known acquired defects such as defective aggregation, decreased resistance to hypotonic shock, and disc‐spherocyte transformation, we have shown that cryopreserved ...
M, Owens   +3 more
openaire   +2 more sources

Platelet Membrane Glycoproteins

2017
Platelets are small anucleate blood cells that are produced in the bone marrow from the cytoplasm of megakaryocytes. Circulating platelets are essential for primary hemostasis and also involved in pathological thrombosis. For the platelet hemostatic functions, platelet surface membrane glycoproteins are crucial to form platelet-subendothelial matrix ...
Hisashi Kato, Yoshiaki Tomiyama
openaire   +1 more source

New polymorphism of platelet membrane glycoproteins

Nature, 1977
THE surface of the human blood platelet is rich in carbohydrate and at least four glycoprotein components have been resolved by gel electrophoresis of isolated platelet plasma membranes1. Two platelet disease states are characterised by a diminution or absence of certain of these glycoproteins2–5: in the case of Bernard-Soulier disease, glycoprotein I (
R B, Bolin, T, Okumra, G A, Jaieson
openaire   +2 more sources

On the role of the major platelet membrane glycoproteins in platelet adhesion to collagen

Thrombosis Research, 1981
Abstract The effect of modification of intact rabbit platelets with chymotrypsin, trypsin or thrombin on platelet adhesion to collagen fibers was determined. Experiments were performed in vitro with washed platelets suspended in a medium containing EGTA to prevent platelet aggregation.
J, Lahav, F A, Meyer
openaire   +2 more sources

Home - About - Disclaimer - Privacy