Results 211 to 220 of about 1,304,823 (301)

Decoding sialidase: physiological roles, pathological pathways, and clinical opportunities. [PDF]

Front Cell Infect Microbiol
Li R, Liu Y, Zou R, Li M.
europepmc   +1 more source

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

Immune thrombocytopenia: Evolving mechanistic understanding and clinical development of new therapies. [PDF]

Tzu Chi Med J
Huang SC, Shen CL, Wu YF.
europepmc   +1 more source

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang, Ruomeng Li, Chuanjiang Yu, Jing Li, Xikun Zhou   +4 more
wiley   +1 more source

Blocking Extracellular Cyclophilin A‐Mediated Adhesion Protects Against Bacterial Infection

MedComm, Volume 7, Issue 10, October 2026.
eCypA promotes bacterial infection by upregulating TGF‐β signaling‐dependent adhesion receptor expression. Pathogens such as IAV, GAS, S. P., and K. P. induce eCypA secretion. Binding of eCypA with TβR2 enhances the affinity of TGF‐β1 and TβR2, which positively regulates adhesion receptors expression via the TGF‐β/Smad signaling pathway, thereby ...
Xiaoyuan Bai, Heqiao Li, Pengtao Jiao, Yuna Zhao, Xiaoxiao Jia, Han Zhong Pei, Zeqiu Fan, Runshan Lin, He Zhang, Beinan Wang, Xinhai Chen, Yuhai Bi, De Chang, Zhongfa Zhang, Yuxin Chen, Wenjun Liu, Lei Sun   +16 more
wiley   +1 more source

Targeting CD38 Across Autoimmune and Plasma Cell-Driven Immune-Mediated Diseases: Rationale, Clinical Evidence, and Emerging Therapeutic Landscape. [PDF]

BioDrugs
Roccatello D, Sciascia S, Rossi D, Fenoglio R.   +3 more
europepmc   +1 more source

Small Proteoglycans, Big Impact: Decorin, Biglycan, and Asporin in Musculoskeletal Tissue Health and Disease

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT The extracellular matrix (ECM) is a dynamic and information‐rich network that integrates structural support with biochemical and mechanical signaling. Among its key regulatory components are the Small Leucine‐Rich Proteoglycans (SLRPs), a family of matrix molecules that coordinate extracellular architecture with cell signaling.
Alessandra Leone, Zsuzsa Jenei‐Lanzl, Frank Zaucke   +2 more
wiley   +1 more source

Cognitive dysfunction in MASLD is linked to platelet activation. [PDF]

Front Neurosci
Chen J, Cheng C, Wang H, Yu T.
europepmc   +1 more source

Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating

Small, Volume 22, Issue 55, 1 October 2026.
Precise engineering of cell membrane‐coated nanoparticles (CMNPs) requires coordinated control over particle size, coating integrity, and membrane leaflet orientation. This review integrates key synthesis parameters, assembly strategies, and analytical methods that govern these features, revealing how structural control underpins biomimetic function ...
Jie Lay Lim, Lingqing Zong, Wei Deng, Maria Kavallaris, Zi Gu   +4 more
wiley   +1 more source

Targeting mRNA delivery using bio-inspired hybrid cell membrane-incorporated liposomes: a novel strategy for cancer therapy. [PDF]

Biomark Res
Gangadaran P, Khan F, Rajendran RL, Dhayalan S, Mahajan AA, Aruljothi KN, Ahn BC.   +6 more
europepmc   +1 more source