ABSTRACT Extracellular vesicles (EVs) mediate intercellular communication within the tumour microenvironment by carrying cargoes from paracrine parent cells. EVs have attracted great research interest for their ability to carry nucleic acids into recipient cells and modulate cellular functions.
Gaoge Sun +11 more
wiley +1 more source
Mechanobiology of cancer-associated thrombosis: from molecular mechanisms to therapeutic innovation. [PDF]
Wang ZT +6 more
europepmc +1 more source
Under shear flow, stretched vWF captures platelets and EVs, and TF‐positive EVs amplify platelet activation and aggregation. Although tumour cells do not bind vWF directly, the resulting microthrombi trap circulating tumour cells and promote metastatic progression.
Yuanyuan Wang +16 more
wiley +1 more source
ITGA2B/ITGB3-Related Macrothrombocytopenia Associated With Gain-of-Function Mutations in ITGA2B or ITGB3 Genes. [PDF]
Wu J +14 more
europepmc +1 more source
Neutrophils acquire extracellular fatty acids or adipocyte‐derived lipids and store them as triglycerides, polarizing into a lipid‐laden phenotype. Lipid‐laden neutrophils are found in the peripheral blood of HFD‐fed mice and patients with MASLD. These neutrophils release extracellular vesicles enriched with triglycerides and microRNAs that deliver ...
Sanjeeb Shrestha +10 more
wiley +1 more source
A Case of Piperacillin-Induced Immune Thrombocytopenia: Diagnostic Challenges and Management. [PDF]
Patel A +4 more
europepmc +1 more source
Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley +1 more source
Mac-2 binding protein glycosylation isomer contributes to identify advanced Fontan-associated liver disease: A retrospective cohort study. [PDF]
Kitsugi K +9 more
europepmc +1 more source
3D Liver Fibrosis Models in Lab: A Novel Modality for Drug Screening
ABSTRACT Liver fibrosis is the common consequence of liver injury caused by a variety of chronic liver disorders. This condition leads to the development of more severe complications, particularly cirrhosis and hepatocellular carcinoma. Despite abundant studies, the fundamental cell and molecular mechanisms of liver fibrosis are still unknown.
Hani Keshavarz Alikhani +10 more
wiley +1 more source
Obinutuzumab-induced acute thrombocytopenia and leukopenia in ANCA-associated glomerulonephritis: case report and literature review. [PDF]
Jin Y, Huang Y, He X.
europepmc +1 more source

