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The Clinical Significance of Platelet Membrane Glycoproteins
Hematology/Oncology Clinics of North America, 1990To mediate their hemostatic functions, platelets must adhere to exposed vascular subendothelium and then aggregate. A variety of membrane glycoprotein receptors for adhesive ligands are present on platelets that promote adhesion and aggregation. Analysis of congenital disorders of platelet glycoproteins has been instrumental in clarifying our knowledge
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Ca2+ influx and platelet membrane glycoproteins.
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1990When aequorin-loaded platelets were stimulated with thrombin, the luminescence of aequorin showed two peaks. From experiments with 1 mM external Ca2+ or 1 mM EGTA, both one-half of the first peak and the entire second peak reflected the influx of Ca2+ from the external medium, and the remaining half of the first peak reflected the mobilization of Ca2 ...
A, Yamaguchi, K, Tanoue, H, Yamazaki
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Further Characterization Of Platelet Membrane Glycoproteins
Thrombosis and Haemostasis, 1981The binding of 125I-labelled lectins to major and minor platelet glycoproteins (GP) and their subunits has been investigated. Human platelets were isolated, washed, solubilized in sodium dodecyl sulphate (SDS) under non-reducing conditions and separated on 5, 7.5 and 10 % non-reduced/reduced 2-D polyacrylamide gels.
P Clezardin +4 more
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[Platelet membrane glycoproteins in thrombocytapheresis and platelet concentrates].
Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine, 1998Membrane glycoprotein (GP) expression on platelets changes during preparation of concentrates and storage. Recent studies proved that the increased expression of the GMP-140 (CD 62), a GP appearing on platelets after activation, correlates with the in vivo recovery of transfused platelets.
J, Dittmann +4 more
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[Biochemistry of platelet membrane glycoproteins].
Nihon rinsho. Japanese journal of clinical medicine, 2003Platelet membranes are rich in glycoproteins which mediate the key functions of platelets, adhesion and aggregation, by their binding of specific adhesive proteins. The membrane glycoproteins were initially identified by surface labeling with 125I or 3H followed by SDS-polyacrylamide gel electrophoresis.
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Platelet membrane glycoproteins in haemostasis.
Clinical laboratory, 2003Platelets play a critical role in both primary and secondary haemostasis. In primary haemostasis, specialised glycoprotein receptors enable platelets to adhere to proteins that are exposed in areas of vascular damage. The process of adhesion, and/or the interaction of soluble agonists with receptors on the platelet, activates the platelets, which are ...
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The Immunogenicity of Platelet Membrane Glycoproteins
Transfusion Medicine Reviews, 1987T J, Kunicki +3 more
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MEMBRANE GLYCOPROTEINS AND HUMAN PLATELET FUNCTION
British Journal of Haematology, 1978A T, Nurden, J P, Caen
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Glycoproteins of the Platelet Plasma Membrane
1985The glycoproteins of the platelet plasma membrane, in common with those of the plasma membranes of other cells, have an important role in the interaction of platelets with their environment and in particular in the platelet’s function of hemostasis.
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Membrane glycoprotein abnormalities in pathological platelets
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1988K J, Clemetson, E F, Lüscher
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