Results 251 to 260 of about 20,129 (301)
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New polymorphism of platelet membrane glycoproteins
Nature, 1977THE surface of the human blood platelet is rich in carbohydrate and at least four glycoprotein components have been resolved by gel electrophoresis of isolated platelet plasma membranes1. Two platelet disease states are characterised by a diminution or absence of certain of these glycoproteins2–5: in the case of Bernard-Soulier disease, glycoprotein I (
R B, Bolin, T, Okumra, G A, Jaieson
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, 1985 Thrombosis and Thrombolysis: Platelet Membrane Glycoproteins
Heart, Lung and Circulation, 2007Over the last quarter of a century, therapy for acute coronary syndromes has rapidly evolved. The major causative factor for acute coronary syndromes, particularly acute myocardial infarction, is now recognised to be coronary thrombosis and therapies using thrombolytic agents to dissolve thrombus or percutaneous coronary interventions (angioplasty and ...
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On the role of the major platelet membrane glycoproteins in platelet adhesion to collagen
Thrombosis Research, 1981Abstract The effect of modification of intact rabbit platelets with chymotrypsin, trypsin or thrombin on platelet adhesion to collagen fibers was determined. Experiments were performed in vitro with washed platelets suspended in a medium containing EGTA to prevent platelet aggregation.
J, Lahav, F A, Meyer
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Studies on human and bovine platelet membrane glycoproteins
International Journal of Biochemistry, 1979Abstract 1. 1. We have re-evaluated the number of platelet membrane glycoproteins with use of sodium dodecyl sulfate—polyacrylamide gel electrophoresis and two highly sensitive detection techniques. 2. 2. The first involves incorporation of the fluorophore dansyi hydrazine into the carbohydrate moiety after post-electrophoresis periodate ...
J F, McMaster, M E, Noelken
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Platelet membrane glycoproteins and their function: An overview
Blut, 1989The membrane glycoproteins (GP) of human platelets act as receptors that mediate two important functions, adhesion to the subendothelial matrix and platelet-platelet cohesion, or aggregation. Many of these glycoprotein receptors exist as noncovalently linked heterodimers, including those that belong to the supergene family of adhesion receptors called ...
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Thrombin Interaction With Platelet Membrane Glycoprotein Ib
Seminars in Thrombosis and Hemostasis, 1996Platelet activation by low doses of thrombin allows the amplification thrombin formation and thereby plays an important role in the development of thrombi. Although thrombin-induced platelet activation is elicited via the cleavage of its specific receptor (TR), platelet membrane glycoprotein Ib (GPIb) is required for responses to low concentrations of ...
M, Jandrot-Perrus +3 more
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Thrombosis Research, 1989
Human platelets contain a single membrane glycoprotein which is susceptible to thrombin proteolysis, glycoprotein V. We have purified 1 mg of glycoprotein V from 10(13) platelets using a combination of gel filtration, hydroxylapatite and ion-exchange chromatographies. Glycoprotein V has a blocked amino-terminus.
R S, Zafar, D A, Walz
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Human platelets contain a single membrane glycoprotein which is susceptible to thrombin proteolysis, glycoprotein V. We have purified 1 mg of glycoprotein V from 10(13) platelets using a combination of gel filtration, hydroxylapatite and ion-exchange chromatographies. Glycoprotein V has a blocked amino-terminus.
R S, Zafar, D A, Walz
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Polymorphisms of Platelet Membrane Glycoproteins
2009Platelet glycoproteins (GPs) act as membrane receptors. Functions of GPs were well studied in GPIa/IIa (integrin α2β1), GPIb/IX/V, GPIIb/IIIa (integrin αIIbβ3), and GPVI. Each GP has a different role in the processes of physiological hemostasis and thrombus formation, such as platelet adhesion to the subendothelial matrix, firm adhesion with subsequent
Yumiko Matsubara +2 more
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Thrombin interaction with platelet membrane glycoprotein Ibα
Trends in Molecular Medicine, 2003The interaction of thrombin with platelet glycoprotein Ibalpha (GPIb alpha) is required for optimal platelet activation. The crystal structures of platelet GPIb alpha bound to thrombin reported by Dumas et al. and Celikel et al. both reveal the simultaneous interaction of GPIb alpha with thrombin exosites I and II but differ markedly regarding how the ...
Frédéric, Adam +3 more
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