Platelet Apoptosis Can Be Triggered Bypassing the Death Receptors
Clinical and Applied Thrombosis/Hemostasis, 2019 In nucleated cells, the extrinsic pathway of the programmed cell death (apoptosis) is triggered by interaction of death ligands of the tumor necrosis factor superfamily with the death receptors on external cell surface membrane.
Valery Leytin PhD +2 more
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The stochastic entry of enveloped viruses: Fusion vs. endocytosis [PDF]
Biophys. J., 93, 1116-1123, (2007), 2007 Viral infection requires the binding of receptors on the target cell membrane to glycoproteins, or ``spikes,'' on the viral membrane. The initial entry is usually classified as fusogenic or endocytotic. However, binding of viral spikes to cell surface receptors not only initiates the viral adhesion and the wrapping process necessary for internalization,
arxiv +1 more source
Combining detection and reconstruction of correlational and quasi-periodic motifs in viral genomic sequences with transitional genome mapping: Application to COVID-19 [PDF]
Journal of Integrated OMICS, 2021, v.11(1) p.5-11, 2020 A method of Transitional Automorphic Mapping of the Genome on Itself (TAMGI) is aimed at combining detection and reconstruction of correlational and quasi-periodic motifs in the viral genomic RNA/DNA sequences. The motifs reconstructed by TAMGI are robust with respect to indels and point mutations and can be tried as putative therapeutic targets.
arxiv +1 more source
Antibodies against complement-regulatory proteins on platelets in immune thrombocytopenia
Platelets, 2017 In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding.
Ursula Unterberger +3 more
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Vaccines, 2023 Kounis syndrome is a multisystem and multidisciplinary disease affecting the circulatory system that can be manifested as spasm and thrombosis. It can occur as allergic, hypersensitivity, anaphylactic, or anaphylactoid reactions associated with the ...
Christos Gogos +7 more
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Interaction of fibrinogen-magnetic nanoparticle bioconjugates with integrin reconstituted into artificial membranes [PDF]
Nanoscale, 2020, 12, 19918, 2020 Magnetic nanoparticles have a broad spectrum of biomedical applications including cell separation, diagnostics and therapy. One key issue is little explored: how do the engineered nanoparticles interact with blood components after injection? The formation of bioconjugates in the bloodstream and subsequent reactions are potentially toxic due to the ...
arxiv +1 more source
Why enveloped viruses need cores -- the contribution of a nucleocapsid core to viral budding [PDF]
, 2017 During the alphavirus lifecycle, a nucleocapsid core buds through the cell membrane to acquire an outer envelope of lipid membrane and viral glycoproteins. However, the presence of a nucleocapsid core is not required for assembly of infectious particles.
arxiv +1 more source
Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat [PDF]
Nature Microbiology 2 (2017), pp. 1523--1532, 2018 The most prominent defence of the unicellular parasite Trypanosoma brucei against the host immune system is a dense coat that comprises a variant surface glycoprotein (VSG). Despite the importance of the VSG family, no complete structure of a VSG has been reported.
arxiv +1 more source
Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection. [PDF]
, 2019 Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis.
Barnard, Karen N +10 more
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Pesquisa de anticorpos antiplaquetários. As primeiras cem amostras estudadas.
Acta Médica Portuguesa, 2000 Two types of platelet alloantigens are considered: type I, which refers to platelet alloantigens shared by platelets and other cells; and type II, which comprises the platelet-specific alloantigens.
M M Campos +3 more
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