, 2021 We describe a new procedure for isolation of glycoproteins IIb (GPIIb) and IIIa (GPIIIa) from human platelet plasma membrane with high yields (2.7 mg of GPIIb and 3.3 mg of GPIIIa per 100 mg of starting platelet membrane proteins), equivalent to a ...
Eirin, M.T. +2 more
core +1 more source
Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma
Advanced Science, EarlyView.Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul +4 more
wiley +1 more source
Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]
, 2012 Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
Cornelia A. Deeg +23 more
core +2 more sources
Neonatal Intracranial Hemorrhage with a Dramatic Outcome Due to Maternal Anti CD36 Antibodies
Reports, 2019 Fetal/neonatal allo-immune thrombocytopenia (FNAIT) results from maternal immunization against fetal platelet-specific antigens (HPA) inherited from the father. Most cases involve HPA located on glycoproteins (GP) IbIX, IaIIa and IIbIIIa.
Gérald Bertrand +5 more
doaj +1 more source
A fibronectin-binding glycoprotein from human platelet membranes [PDF]
Biochemical Journal, 1981 Fibronectin (‘cold-insoluble globulin’) has been suggested as a possible mediator of platelet adhesion. A fibronectin-binding protein as partially purified from washed solubilized human platelet membranes by affinity chromatography on fibronectin-Sepharose.
M S, Hansen, I, Clemmensen
openaire +2 more sources
Advanced Science, EarlyView.Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng +14 more
wiley +1 more source
Investigations into effects of 12-lipoxygenase and NADPH oxidase on platelet activity, and influences of dietary dark chocolate [PDF]
, 2012 PhDPlatelets play a pivotal role in both normal hemostasis and pathological bleeding and importantly also contribute to the development of atherothrombosis.
Zain, Zetty Nadia Mohd
core +4 more sources
EFFECT OF OZONE ACTIVATED PLATELET RICH PLASMA ON THE MANAGEMENT OF GRADE II FURCATION INVOLVEMENT (COMPARATIVEEXPERIMENTALSTUDY) [PDF]
Alexandria Dental Journal, 2019 INTRODUCTION: Furcation defects are a frequent finding in periodontitis patients. Activated platelets release numerous proteins, among them adhesive glycoproteins and growth factors.
Gehan S. Kotry +3 more
doaj +1 more source
Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke
Annals of Neurology, EarlyView.Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary +21 more
wiley +1 more source
Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway [PDF]
, 2003 Background: The regulation of platelet function by pharmacological agents that modulate platelet signaling haspharmacolo proven a successful approach to the prevention of thrombosis.
Cicmil, M +23 more
core +1 more source