Results 71 to 80 of about 1,304,823 (301)

Clinical and genetic aspects of Bernard-Soulier syndrome: searching for genotype/phenotype correlations

Haematologica, 2011
Background Bernard-Soulier syndrome is a severe bleeding disease due to a defect of GPIb/IX/V, a platelet complex that binds the von Willebrand factor.
Anna Savoia, Annalisa Pastore, Daniela De Rocco, Elisa Civaschi, Mariateresa Di Stazio, Roberta Bottega, Federica Melazzini, Valeria Bozzi, Alessandro Pecci, Silvana Magrin, Carlo L. Balduini, Patrizia Noris   +11 more
doaj   +1 more source

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 [PDF]

, 2008
Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2.
Pearce, AC, Watson, Steve P, Watson, Steve P., Eble, JA, Pearce, Andrew C., Pearce, A C, Hughes, C E, McGlade, Jane, Eble, Johannes A., Auger, Jocelyn; id_orcid, McGlade, J, Auger, Jocelyn M., Watson, Steve; id_orcid, Eble, J A, Pearce, Andrew C, Auger, J M, Watson, S P, Hughes, Craig, Hughes, C.E, Hughes, Craig E.   +19 more
core   +2 more sources

Lysosomal Membrane Glycoproteins in Platelets [PDF]

Thrombosis and Haemostasis, 1992
M J, Metzelaar, H C, Clevers
openaire   +4 more sources

Bernard–Soulier syndrome caused by two novel heterozygous GP1BA gene mutations: a case report and literature review

Hematology
Background: Bernard–Soulier syndrome (BSS) is a rare inherited macrothrombocytopenia, usually autosomal recessive, which is characterized by prolonged bleeding, thrombocytopenia, and abnormally large platelets.Methods: For more than 6 years, we ...
Senlin Zhang, Jing Ling, Kai Cui, Shihong Zhan, Jiajia Zheng, Wenyi Wang, Junjie Fan, Shaoyan Hu   +7 more
doaj   +1 more source

Interplaying of regulatory T-cells and related chemokines in immune thrombocytopenic purpura patients

Iraqi Journal of Hematology, 2020
BACKGROUND: Chronic immune thrombocytopenic purpura (ITP) is an immune-mediated bleeding disorder, in which platelets are opsonized by autoantibodies directed against platelet surface membrane glycoproteins, and prematurely cleared and destructed by Fc ...
Zeyad A Shabeeb, Yusur F Faraj, Majed M Mahmood, Baan Abdulatif Mtashar   +3 more
doaj   +1 more source

Percutaneous transluminal coronary angioplasty in the right ventricle myocardial infarction treatment [PDF]

Vojnosanitetski Pregled, 2005
Background/Aim. To present the results of percutaneous transluminal coronary angioplasty (PTCA) in the treatment of the patients with acute right ventricle myocardial infarction (ARVMI), with adjuvant analyses of the obtained results in the period of ...
Rafajlovski Saša I., Orozović Vjekoslav, Ristić-Anđelkov Anđelka, Rađen Goran   +3 more
doaj   +1 more source

Analysis of Platelet Membrane Glycoproteins in Myeloproliferative Disorders

Blood & Vessel, 1979
The platelet membrane glycoproteins (GP) of myeloproliperetion disorders(12 cases) were analyzed by SDS PAGE. In GP I peak there was no difference between normal and this disorders in the 125I incorporation rate but the percentage of GP I to all PAS stained peaks was reduced in chronic myelogenous leukemia (CML) but increased in primary thrombo ...
FUJIMURA, Kingo, TAKETOMI, Yoshinori, KURAMOTO, Atsushi   +2 more
openaire   +2 more sources

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Protein glycosylation in the gram-negative gamma proteobacterium photorhabdus luminescens [PDF]

, 2011
The objective of this research was to investigate the possibility that Photorhabdus luminescens produces glycoproteins and thus contains a protein glycosylation system. P. luminescens is a pathogen of insects and a symbiont of soil nematodes.
Fox, Mary
core   +2 more sources