Ever since platelet transfusions were shown to reduce mortality from haemorrhage in patients with acute leukaemia in the 1950s, the use of this therapy has steadily grown to become an essential part of the treatment of cancer, haematological malignancies, marrow failure, and haematopoietic stem cell transplantation.
David F, Stroncek, Paolo, Rebulla
openaire +2 more sources
Research progress of neonatal low-threshold platelet transfusion strategy
Neonatal thrombocytopenia is one of the common hematological abnormalities in neonates, especially premature infants. Platelet transfusion is an effective method of treating neonatal thrombocytopenia, but its threshold selection and timing are ...
Chunfeng LIANG +4 more
doaj +1 more source
Objective To retrospectively analyze the effect of AB platelet secondary compatible transfusion on the efficacy of matched platelet transfusion. Methods A total of 2 276 cases of platelet transfusion in our hospital were selected from November 2020 to ...
Yan HU +6 more
doaj +1 more source
Microfluidic flow chambers using reconstituted blood to model hemostasis and platelet transfusion in vitro [PDF]
Blood platelets prepared for transfusion gradually lose hemostatic function during storage. Platelet function can be investigated using a variety of (indirect) in vitro experiments, but none of these is as comprehensive as microfluidic flow chambers.
Compernolle, Veerle +4 more
core +2 more sources
Platelet count and transfusion requirements during moderate or severe postpartum haemorrhage [PDF]
Limited data exist on platelet transfusion during postpartum haemorrhage. We retrospectively analysed a consecutive cohort from a single centre of 347 women with moderate or severe postpartum haemorrhage, transfused according to national guidelines ...
D. Burckett st Laurent +9 more
core +2 more sources
Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice [PDF]
We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals.
Carestia, Agostina +9 more
core +1 more source
Intraoperative blood transfusions in highly alloimmunized patients undergoing orthotopic liver transplantation. [PDF]
Intraoperative blood requirements were analyzed in patients undergoing primary orthotopic liver transplantation and divided into two groups on the basis of panel reactive antibody of pretransplant serum measured by lymphocytotoxicity testing.
Duquesnoy, RJ +5 more
core +1 more source
Platelet transfusion in patients with liver cirrhosis cross-talk with neutrophil: Prospective study
Introduction: Immune dysfunction and thrombocytopenia are common features in liver cirrhosis. Platelet transfusion is the most widely used therapeutic approach for thrombocytopenia when indicated.
Mona Mahmoud Hassouna +4 more
doaj +1 more source
Platelet transfusion refractoriness [PDF]
SummaryThe platelet, a fascinating anucleate cell, is critically important for haemostasis. Platelet transfusions have greatly reduced the incidence of major haemorrhagic complications associated with the management of haematological and oncological disorders. However, some patients fail to receive the full benefit of platelet transfusions because they
Eldad, Hod, Joseph, Schwartz
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Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study [PDF]
Objective: Postoperative bleeding is still one of the most common complications of cardiac surgery. Antifibrinolytic agents successfully reduce bleeding, but there are controversies concerning adverse effects after their systemic use.
Barić, Davor +7 more
core +1 more source

