Results 51 to 60 of about 5,003 (295)
Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of ...
Alexander Åkesson+7 more
doaj +1 more source
Management of Patients Refractory to Platelet Transfusion
AbstractObjective.—To present a current assessment and practical approach to the diagnosis and management of patients who are refractory to platelet transfusions.Design.—A task force was convened by the College of American Pathologists under the auspices of the Transfusion Medicine Resource Committee for the purposes of outlining current concepts in ...
Thomas S. Kickler+5 more
openaire +3 more sources
Platelet Transfusion-Insights from Current Practice to Future Development. [PDF]
Since the late sixties, therapeutic or prophylactic platelet transfusion has been used to relieve hemorrhagic complications of patients with, e.g., thrombocytopenia, platelet dysfunction, and injuries, and is an essential part of the supportive care in ...
Capraru, Annina+5 more
core +1 more source
Structure and thermodynamics of platelet dispersions [PDF]
Various properties of fluids consisting of platelike particles differ from the corresponding ones of fluids consisting of spherical particles because interactions between platelets depend on their mutual orientations. One of the main issues in this topic is to understand how structural properties of such fluids depend on factors such as the shape of ...
arxiv +1 more source
Background. In addition to anti-HLA-I and anti-HPA-antibodies and specific cytotoxic T-lymphocytes, another cause of immune refractoriness to donor's platelet transfusions could be a platelet-associated different classes immunoglobulins PAIg (G, M, A ...
A. F. Rakhmani+11 more
doaj +1 more source
[Objective] To compare and analyze the efficacy of platelet transfusion in patients with different doses, and to analyze the risk factors for platelet transfusion refractoriness.
ZHU Jianling+5 more
doaj +1 more source
Drug-induced immune thrombocytopenia associated with use of tyrosine kinase inhibitor imatinib [PDF]
Since their introduction in the late 1990s, tyrosine kinase Inhibitors (TKIs) have been widely used for the treatment of various cancers. The side effects of the TKI imatinib are well-documented in the literature and include fatigue, skin rash ...
Cserti-Gazdewich, Christine+1 more
core +1 more source
ABSTRACT Background Dual antiplatelet therapy (DAPT) is standard following percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). Preloading is the practice of administering both aspirin and a P2Y12 inhibitor before PCI. DAPT preloading is common practice, however clinical trial evidence demonstrating benefit is lacking.
Shi Hui Goh+11 more
wiley +1 more source
Three-dimensional Multiscale Model of Deformable Platelets Adhesion to Vessel Wall in Blood Flow [PDF]
When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering and rolling on the injured endothelium is a critical initial step in blood clot formation.
arxiv +1 more source
Dynamic Formation of Preferentially Lattice Oriented, Self Trapped Hydrogen Clusters [PDF]
A series of MD and DFT simulations were performed to investigate hydrogen self-clustering and retention in tungsten. Using a newly develop machine learned interatomic potential, spontaneous formation of hydrogen platelets was observed after implanting low-energy hydrogen into tungsten at high fluxes and temperatures.
arxiv