Results 1 to 10 of about 527,915 (318)

Lyophilized platelets inhibit platelet aggregation with simultaneous paradoxical promotion of platelet adhesion

Frontiers in Bioengineering and Biotechnology, 2022
Lyophilized platelets have been explored as a potential hemostatic agent due to their long-term ambient storage capabilities that make them readily available in various scenarios.
Brian Schnoor, Anne-Laure Papa
doaj   +1 more source

Exploitation of platelets for antitumor drug delivery and modulation of the tumor immune microenvironment

Acta Materia Medica, 2023
Platelets are blood components traditionally believed to have fundamental roles in vascular hemostasis and thrombosis. In recent years, platelets have received new attention for their roles in tumorigenesis and progression. On the one hand, platelets are
Jie Guo, Meng-Fei Wang, Yong Zhu, Fumio Watari, Yong-Hong Xu, Xiao Chen   +5 more
doaj   +1 more source

Age-Dependent Surface Receptor Expression Patterns in Immature Versus Mature Platelets in Mouse Models of Regenerative Thrombocytopenia

Cells, 2023
Aging is a multifaceted process that unfolds at both the individual and cellular levels, resulting in changes in platelet count and platelet reactivity.
Anita Pirabe, Sabine Frühwirth, Laura Brunnthaler, Hubert Hackl, Anna Schmuckenschlager, Waltraud C. Schrottmaier, Alice Assinger   +6 more
doaj   +1 more source

Platelets and Platelet Phosphatides in Uremia [PDF]

Blood, 1960
Abstract 1. The platelets of 20 uremic subjects were studied, utilizing the following procedures; phase platelet count, serum prothrombin time, thromboplastin generation test with evaluation of plasma, serum, and platelet reagents. 2.
G, ALTSCHULER, A J, MARCUS, H L, ULLMAN
openaire   +2 more sources

Avatrombopag improves thrombocytopenia in MYH9-related disorder following eltrombopag treatment failure

Platelets, 2022
MYH9-related disorder (MYH9-RD) is autosomal dominant thrombocytopenia caused by mutations in the MYH9 gene, which codes for the non-muscle myosin-IIA heavy chain. We present a case of a 24-year-old Chinese man with MYH9-RD who was initially misdiagnosed
Abdul Rehman Arif, Miaomiao Zhao, Wenlan Chen, Mei Xue, Shanshan Luo, Yadan Wang   +5 more
doaj   +1 more source

Differential expression of exosomal microRNAs in fresh and senescent apheresis platelet concentrates

Platelets, 2022
Patients have a high risk of suffering adverse reactions after receiving platelet products stored for 5 days. Bioactive exosomes in platelet products can be accumulated during storage, which is associated with adverse reactions.
Ziyue Mi, Li Gong, Yujie Kong, Peizhe Zhao, Yonghua Yin, Haixia Xu, Li Tian, Zhong Liu   +7 more
doaj   +1 more source

Sex-specific relationship between blood selenium levels and platelet count in a large cohort representative of the United States population

Platelets, 2022
While several small studies have found that selenium deficiency is associated with low platelet counts, they lack generalizability. We used data from the National Health and Nutrition Examination Surveys collected over a 12-year period.
Neda Rehan, Rehan Qayyum
doaj   +1 more source

Gender-related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy: the RE-SCORE multicenter prospective registry

Platelets, 2022
The risk of bleeding as predicted by the PRECISE-DAPT score can vary over time after percutaneous coronary intervention (PCI). We sought to compare the predictive ability of the PRECISE-DAPT score calculated at baseline and reassessed during follow-up in
Francesco Pelliccia, Felice Gragnano, Vincenzo Pasceri, Giuseppe Marazzi, Luca Cacciotti, Attilio Placanica, Giampaolo Niccoli, Tullio Palmerini, Giulio Speciale, Antonino Granatelli, Paolo Calabrò   +10 more
doaj   +1 more source

Diagnostic and prognostic role of platelets in patients with sepsis and septic shock

Platelets, 2023
Studies investigating the prognostic role of platelets commonly include critically ill patients, whereas data regarding the prognostic impact of platelet count in patients admitted with sepsis and septic shock is limited.
Tobias Schupp, Kathrin Weidner, Jonas Rusnak, Schanas Jawhar, Jan Forner, Floriana Dulatahu, Lea Marie Brück, Ursula Hoffmann, Maximilian Kittel, Thomas Bertsch, Ibrahim Akin, Michael Behnes   +11 more
doaj   +1 more source

Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib

Platelets, 2023
Spleen tyrosine kinase (SYK) is an important regulatory molecule of signal transduction pathways involved in the pathogenesis of autoimmune diseases such as immune thrombocytopenia (ITP), and the SYK-signaling pathway has emerged as a potential target ...
Nichola Cooper, Waleed Ghanima, Quentin A Hill, Phillip LR Nicolson, Vadim Markovtsov, Craig Kessler   +5 more
doaj   +1 more source