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Platelet Subpopulations in Health and Disease: Heterogeneity, Clinical Associations, and Therapeutic Targeting [PDF]
CellsPlatelets are often described in simple terms as small anucleate cells that mediate hemostasis, but studies over more than half a century have shown that circulating platelets are heterogeneous in size, density, age, and functional responses.
Deepa Gautam +2 more
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Frontiers in Bioengineering and Biotechnology, 2022 Lyophilized platelets have been explored as a potential hemostatic agent due to their long-term ambient storage capabilities that make them readily available in various scenarios.
Brian Schnoor, Anne-Laure Papa
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Acta Materia Medica, 2023 Platelets are blood components traditionally believed to have fundamental roles in vascular hemostasis and thrombosis. In recent years, platelets have received new attention for their roles in tumorigenesis and progression. On the one hand, platelets are
Jie Guo +5 more
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Cells, 2023 Aging is a multifaceted process that unfolds at both the individual and cellular levels, resulting in changes in platelet count and platelet reactivity.
Anita Pirabe +6 more
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Медицинская иммунология, 2018 Platelets are the smallest blood cells, and yet their total volume and surface area exceed those of all types of leukocytes combined. Platelets are produced by the bone marrow megakaryocytes and megakaryocytes in the lung microvessels.
N. B. Serebryanaya +3 more
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Protocol for Murine/Mouse Platelets Isolation and Their Reintroduction in vivo
Bio-Protocol, 2017 Platelets and coagulation have long been known to be essential for metastasis in experimental models. In order to study the interactions between tumor cells, platelets and endothelium, we have adapted methods used in coagulation research for the ...
Jae Im, Ruth Muschel
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Assessment of neonatal, cord, and adult platelet granule trafficking and secretion
Platelets, 2020 Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis.
Anh T. P. Ngo +12 more
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Analysis of adenoviral attachment to human platelets
Virology Journal, 2009 Background Systemic adenoviral (Ad) vector administration is associated with thrombocytopenia. Recently, Ad interaction with mouse platelets emerged as a key player determining liver uptake and platelet clearance.
Urieli-Shoval Simcha +5 more
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Platelets, 2018 Platelets are recognized to be physiologically and functionally heterogeneous. An example of the diversity in reactivity is the formation of a distinct subpopulation of procoagulant phosphatidylserine (PS)-exposing platelets upon activation. Platelet age
Emily C. Reddy +4 more
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Humanized mouse models for inherited thrombocytopenia studies
Platelets, 2023 Inherited thrombocytopenia (IT) is a group of hereditary disorders characterized by a reduced platelet count as the main clinical manifestation, and often with abnormal platelet function, which can subsequently lead to impaired hemostasis.
Xiaojie Wang +13 more
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