Results 1 to 10 of about 950,538 (340)

Challenges on the diagnostic approach of inherited platelet function disorders: Is a paradigm change necessary?

open access: yesPlatelets, 2018
Inherited platelet function disorders (IPFD) have been assessed for more than 50 years by aggregation- and secretion-based tests. Several decision trees are available intending to standardize the investigation of IPFD.
Tiago Nava   +2 more
doaj   +1 more source

Emerging roles for platelets as immune and inflammatory cells.

open access: yesBlood, 2014
Despite their small size and anucleate status, platelets have diverse roles in vascular biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also immune cells that initiate and accelerate many vascular inflammatory ...
C. Morrell   +3 more
semanticscholar   +1 more source

Platelet-rich concentrate in serum-free medium enhances cartilage-specific extracellular matrix synthesis and reduces chondrocyte hypertrophy of human mesenchymal stromal cells encapsulated in alginate

open access: yesPlatelets, 2019
Platelet-rich concentrate (PRC), used in conjunction with other chondroinductive growth factors, have been shown to induce chondrogenesis of human mesenchymal stromal cells (hMSC) in pellet culture.
Shani Samuel   +5 more
doaj   +1 more source

Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases.

open access: yesPhysiological Reviews, 2016
Platelets are essential for physiological hemostasis and are central in pathological thrombosis. These are their traditional and best known activities in health and disease.
E. Middleton, A. Weyrich, G. Zimmerman
semanticscholar   +1 more source

Two novel variants of uncertain significance in GP9 associated with Bernard–Soulier syndrome: Are they true mutations?

open access: yesPlatelets, 2018
Bernard–Soulier syndrome (BSS) is an autosomal recessive major thrombocytopathy, the symptoms of which are mainly marked by mucocutaneous bleeding.
P. Boisseau   +12 more
doaj   +1 more source

Platelet Rho GTPase regulation in physiology and disease

open access: yesPlatelets, 2019
Rho GTPases are master orchestrators of cytoskeletal dynamics and serve critical roles in platelet physiology to promote hemostasis or pathology in thrombotic, inflammatory and other disease states.
Joseph E. Aslan
doaj   +1 more source

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.

open access: yesJournal of Clinical Investigation, 2012
There is emerging evidence that platelets are major contributors to inflammatory processes through intimate associations with innate immune cells. Here, we report that activated platelets induce the formation of neutrophil extracellular traps (NETs) in ...
A. Caudrillier   +8 more
semanticscholar   +1 more source

An update on quality control for the PFA-100/PFA-200

open access: yesPlatelets, 2018
Testing of platelet function comprises a crucial element of hemostasis assessment, particularly for investigations into bleeding and/or bruising. The Platelet Function Analyzer (PFA)-100 is the most utilized primary hemostasis-screening test system ...
Emmanuel J. Favaloro, Roslyn Bonar
doaj   +1 more source

Platelet aggregation in healthy women during normal pregnancy - a longitudinal study

open access: yesPlatelets, 2019
Increased platelet activation is involved in obstetric complications such as preeclampsia and intrauterine growth retardation. It is of interest to study platelet aggregation during pregnancy, since increased aggregation theoretically could be a ...
Lennart Rune Fredrik Blomqvist   +3 more
doaj   +1 more source

Platelets and Infections – Complex Interactions with Bacteria

open access: yesFrontiers in Immunology, 2015
Platelets can be considered sentinels of vascular system due to their high number in the circulation and to the range of functional immunoreceptors they express.
H. Hamzeh-Cognasse   +5 more
semanticscholar   +1 more source

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