Results 51 to 60 of about 2,179,474 (280)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The Use of Digital Twins to Address Smart Tourist Destinations’ Future Challenges

Platforms
This research aims to conceptualise the use of the digital twins (DT) tool in tourism to address smart tourist destinations’ future challenges to enhance tourists’ experiences and residents’ quality of life through better services developed by DTs.
Lázaro Florido-Benítez
doaj   +1 more source

Complementary Cell Lines for Protease Gene-Deleted Single-Cycle Adenovirus Vectors

Cells, 2023
To increase the safety of adenovirus vector (AdV)-based therapy without reducing its efficacy, a single-cycle adenovirus vector (SC-AdV) with a deletion in the protease gene (PS) was developed in order to be used as a substitute for the replication ...
Seyyed Mehdy Elahi, Nazila Nazemi-Moghaddam, Claire Guilbault, Mélanie Simoneau, Rénald Gilbert   +4 more
doaj   +1 more source

Debiasing Desire: Addressing Bias & Discrimination on Intimate Platforms

, 2018
Designing technical systems to be resistant to bias and discrimination represents vital new terrain for researchers, policymakers, and the anti-discrimination project more broadly.
Barocas, Solon, Hutson, Jevan, Levy, Karen, Taft, Jessie G.   +3 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

DDMMO Website Quality, Destination Image and Intention to Use Metaverse Platforms

Platforms
Background/Objectives: Destination Development, Management, and Marketing Organizations (DDMMOs) have the power to influence perceptions and behaviors regarding both actual and virtual travel in the rapidly changing landscape of digital environments ...
Georgios A. Deirmentzoglou, Eirini Vlassi, Eleni E. Anastasopoulou   +2 more
doaj   +1 more source

Comprehensive analyses of genomes, transcriptomes and metabolites of neem tree [PDF]

PeerJ, 2015
Neem (Azadirachta indica A. Juss) is one of the most versatile tropical evergreen tree species known in India since the Vedic period (1500 BC–600 BC). Neem tree is a rich source of limonoids, having a wide spectrum of activity against insect pests and ...
Nagesh A. Kuravadi, Vijay Yenagi, Kannan Rangiah, HB Mahesh, Anantharamanan Rajamani, Meghana D. Shirke, Heikham Russiachand, Ramya Malarini Loganathan, Chandana Shankara Lingu, Shilpa Siddappa, Aishwarya Ramamurthy, BN Sathyanarayana, Malali Gowda   +12 more
doaj   +2 more sources

Unique Equilibrium in Two-Part Tariff Competition between Two-Sided Platforms [PDF]

, 2010
Two-sided market models in which platforms compete via two-part tariffs, i.e. a subscription and a per-transaction fee, are often plagued by a continuum of equilibria.
Reisinger, Markus
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source