Results 161 to 170 of about 3,583 (200)
Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma
Cell, 2017 The lateral ventricle subventricular zone (SVZ) is a frequent and consequential site of pediatric and adult glioma spread, but the cellular and molecular mechanisms mediating this are poorly understood.
Surya Nagaraja +2 more
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Structure of Pleiotrophin- and Hepatocyte Growth Factor-binding Sulfated Hexasaccharide Determined by Biochemical and Computational Approaches [PDF]
Journal of Biological Chemistry, 2010 Endogenous pleiotrophin and hepatocyte growth factor (HGF) mediate the neurite outgrowth-promoting activity of chondroitin sulfate (CS)/dermatan sulfate (DS) hybrid chains isolated from embryonic pig brain.
Fuchuan Li +2 more
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Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease
Angiogenesis, 2017 Angiogenic factors play an important role in the pathogenesis of diabetic retinopathy (DR), neovascular age-related macular degeneration (nAMD) and retinopathy of prematurity (ROP).
Michelle E Leblanc +2 more
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Pleiotrophin Expression during Odontogenesis [PDF]
Journal of Histochemistry and Cytochemistry, 2012 Pleiotrophin (PTN) is an extracellular matrix–associated growth factor and chemokine expressed in mesodermal and ectodermal cells. It plays an important role in osteoblast recruitment and differentiation. There is limited information currently available about PTN expression during odontoblast differentiation and tooth formation, and thus the authors ...
Heidi Erlandsen +2 more
exaly +3 more sources
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Midkine and pleiotrophin in neural development and cancer
Cancer Letters, 2004The midkine (MK) family consists of only two members, namely heparin-binding growth factors MK and pleiotrophin (PTN). During embryogenesis, MK is highly expressed in the mid-gestational period, whereas PTN expression reaches the maximum level around birth.
Kenji Kadomatsu
exaly +3 more sources
Joint Bone Spine, 2013 Objectives: Pleiotrophin is a heparin-binding growth factor expressed in embryonic but not mature cartilage, suggesting a role in cartilage development. Elucidation of the molecular changes observed during the remodelling process in osteoarthritis is of ...
Angelos Kaspiris +2 more
exaly +1 more source
The role of pleiotrophin in bone repair
Injury, 2014Bone has an enormous capacity for growth, regeneration, and remodelling, largely due to induction of osteoblasts that are recruited to the site of bone formation. Although the pathways involved have not been fully elucidated, it is well accepted that the immediate environment of the cells is likely to play a role via cell–matrix interactions, mediated ...
Margarita, Lamprou +4 more
openaire +2 more sources
The effects of pleiotrophin in proliferative vitreoretinopathy
Graefe's Archive for Clinical and Experimental Ophthalmology, 2017The purpose of our study was to investigate the effects of pleiotrophin (PTN) in proliferative vitreoretinopathy (PVR) both in vitro and in vivo.Immunofluorescence was used to observe the PTN expression in periretinal membrane samples from patients with PVR and controls. ARPE-19 cells were exposed to TGF-β1.
Xue, Ding +7 more
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Pleiotrophin and peripheral nerve injury
Neurosurgical Review, 2009The proto-oncogene pleiotrophin, discovered in 1989, was considered as a multifunctional growth factor, which played an important role in tumor occurrence, development, and central nervous system. The latest research showed that pleiotrophin signal pathway probably participated in neural repair after peripheral nerve injury, especially in the following
Li, Jin +3 more
openaire +2 more sources