Results 31 to 40 of about 18,976 (183)

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Safety and Efficacy of Direct Cryobiopsy Specimen Retrieval Through the 3.0‐mm Working Channel of a Therapeutic Bronchoscope Using a 1.1‐mm Cryoprobe: A Multicentre Prospective Observational Study

Respirology, EarlyView.
Safety and efficacy of direct 1.1‐mm cryobiopsy specimen retrieval through a 3.0‐mm therapeutic bronchoscope channel were evaluated. The technique achieved 87.5% overall diagnostic yield, produced specimens three times larger than forceps biopsy, and caused Grade 3 bleeding in only 2.1%.
Yuki Takigawa, Masahide Oki, Ken Sato, Suzuka Matsuoka, Atsushi Torii, Jun Nishimura, Yuka Shinohara, Hiromi Watanabe, Masahiro Sano, Kenichiro Kudo, Akiko Sato, Yoshihito Kogure, Keiichi Fujiwara, Takuo Shibayama   +13 more
wiley   +1 more source

Epidemiology and clinical characteristics of mesothelioma in the Chinese population: a multicenter study

Therapeutic Advances in Medical Oncology
Background: Mesothelioma is a rare and highly aggressive tumor that causes severe damage. However, there is a lack of systematic reports on the incidence and clinical characteristics of mesothelioma in the Chinese population.
Shengjie Yang, Yue Hao, Ke Wang, Haipeng Xu, Long Huang, Ling Xu, Rui Meng, Bihui Li, Jianhui Huang, Youcai Zhu, Xuefei Shi, Dong Wang, Ziyan Yang, Zhenying Guo, Jingxun Wu, Wenfeng Li, Jianfei Fu, Yinghua Ji, Zongyang Yu, Miao Li, Huijing Feng, Lin Wang, Qing Ji, Wenjun Tang, Zhengbo Song, Chunwei Xu, Qian Wang   +26 more
doaj   +1 more source

Pleural Mesothelioma in the Era of Immunotherapy

Clinical Medicine Insights: Oncology, 2023
Over the course of the last decade, immunotherapy has revolutionised the management of a great number of cancer types. The treatment of pleural mesothelioma, a rare and highly aggressive cancer, is also being transformed by immunotherapy. The recent combination of ipilimumab and nivolumab improved overall survival compared with platinum-based ...
Chevallier, Mathieu, Kim, Floryane, Friedlaender, Alex, Addeo, Alfredo   +3 more
openaire   +3 more sources

LINC00892 inhibits hepatocellular carcinoma progression through SBDS/EIF6‐mediated ribosomal stress and interacting with the immune microenvironment

VIEW, EarlyView.
LINC00892 is lowly expressed in HCC. LINC00892 overexpression induces ribosomal stress via inhibiting SBDS, restrains EIF6 nuclear translocation and activates p53 pathway. LINC00892 overexpression and p53 activation jointly suppress HCC progression. High LINC00892 is associted with infiltration of CD8+ T cells, B cells and macrophages, and associated ...
Xu Zhang, Lina Ma, Juan Ma, Long Hai, Lina Wu, Xueyan Feng, Xiangchun Ding   +6 more
wiley   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

Value of plasma and pleural effusion fibulin-3 levels in the diagnosis of malignant pleural mesothelioma effusions

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that arises from the surface cells of the pleura with a poor survival rate.
Alaa eldin M. Elgazzar, Sameh Embarak, Ali M. Refat, Ahmed Bakry, Ahmed Mokhtar   +4 more
doaj   +1 more source

Pleural Plaques and the Risk of Pleural Mesothelioma [PDF]

JNCI: Journal of the National Cancer Institute, 2013
The association between pleural plaques and pleural mesothelioma remains controversial. The present study was designed to examine the association between pleural plaques on computed tomography (CT) scan and the risk of pleural mesothelioma in a follow-up study of asbestos-exposed workers.Retired or unemployed workers previously occupationally exposed ...
Jean-Claude, Pairon, François, Laurent, Mickaël, Rinaldo, Bénédicte, Clin, Pascal, Andujar, Jacques, Ameille, Patrick, Brochard, Soizick, Chammings, Gilbert, Ferretti, Françoise, Galateau-Sallé, Antoine, Gislard, Marc, Letourneux, Amandine, Luc, Evelyne, Schorlé, Christophe, Paris   +14 more
openaire   +2 more sources