Results 11 to 20 of about 31,395 (237)

Plexiform neurofibroma

Radiopaedia.org, 2021
Irvine Sihlahla
semanticscholar   +6 more sources

Plexiform Neurofibroma

RadioGraphics
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Shehbaz Ansari, Irene Dixe de Oliveira Santo, Pouria Yazdian Anari, Mohamed Badawy, Jonathan A. Flug   +4 more
wiley   +4 more sources

Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage

Journal of Pharmacology and Experimental Therapeutics, 2023
Individuals with neurofibromatosis type 1 develop rat sarcoma virus (RAS)–mitogen-activated protein kinase–mitogen-activated and extracellular signal-regulated kinase (RAS-MAPK-MEK)–driven nerve tumors called neurofibromas.
Mark Jackson, Niousha Ahmari, Jianqiang Wu, Tilat A Rizvi, E. Fugate, Mi-Ok Kim, E. Dombi, Heribert Arnhof, G. Boehmelt, M. Düchs, Clive J Long, U. Maier, F. Trapani, M. H. Hofmann, N. Ratner   +14 more
semanticscholar   +1 more source

Plexiform neurofibroma [PDF]

Radiopaedia.org, 2020
Dai Roberts, F. Salahshour
semanticscholar   +3 more sources

Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma.

Clinical Cancer Research, 2023
PURPOSE Plexiform neurofibromas (PNF) are peripheral nerve sheath tumors that cause significant morbidity in persons with neurofibromatosis type 1 (NF1), yet treatment options remain limited.
Alyssa C Flint, Dana K. Mitchell, Steve Angus, A. Smith, Waylan K Bessler, Li Jiang, H. Mang, Xiaohong Li, Qingbo Lu, B. Rodriguez, G. Sandusky, A. Masters, Chi Zhang, P. Dang, Jenna K. Koenig, Gary L. Johnson, W. Shen, Jiangang Liu, A. Aggarwal, Gregory P. Donoho, Melinda D Willard, S. Bhagwat, D. Clapp, Steven D. Rhodes   +23 more
semanticscholar   +1 more source

Superimposed Mosaicism in the Form of Extremely Extended Segmental Plexiform Neurofibroma Caused by a Novel Pathogenic Variant in the NF1 Gene

International Journal of Molecular Sciences, 2023
Plexiform neurofibromas occurring in approximately 20–50% of all neurofibromatosis type-1 (NF1) cases are histologically benign tumors, but they can be fatal due to compression of vital structures or transformation to malignant sarcomas or malignant ...
K. Veres, J. Bene, K. Hadzsiev, M. Garami, Sára Pálla, R. Happle, M. Medvecz, Z. Szalai   +7 more
semanticscholar   +1 more source

Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment

JCI Insight, 2022
To define alterations early in tumor formation, we studied nerve tumors in neurofibromatosis 1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas, benign tumors driven by NF1 loss in Schwann cells (SCs).
Leah J. Kershner, Kwangmin Choi, Jianqiang Wu, Xiyuan Zhang, Melissa R. Perrino, N. Salomonis, J. Shern, N. Ratner   +7 more
semanticscholar   +1 more source

Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial. [PDF]

Nat Med
Gross AM, O'Sullivan Coyne G, Dombi E, Tibery C, Herrick WG, Martin S, Angus SP, Shern JF, Rhodes SD, Foster JC, Rubinstein LV, Baldwin A, Davis C, Dixon SAH, Fagan M, Ong MJ, Wolters PL, Tamula MA, Reid O, Sankaran H, Fang F, Govindharajulu JP, Browne AT, Kaplan RN, Heisey K, On TJ, Xuei X, Zhang X, Johnson BC, Parchment RE, Clapp DW, Srivastava AK, Doroshow JH, Chen AP, Widemann BC.   +34 more
europepmc   +2 more sources

Clinical and humanistic burden among pediatric patients with neurofibromatosis type 1 and plexiform neurofibroma in the USA

Child's Nervous System, 2022
To assess clinical and humanistic burden among pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibroma (PN) in the USA. NF1-PN patients aged 8–18 years (treatment-naïve or ≤ 1 month of selumetinib treatment) and their caregivers
Xiaoqin Yang, H. Yoo, S. Amin, W. Cheng, S. Sundaresan, Lujia Zhang, M. Duh   +6 more
semanticscholar   +1 more source

A Case Series of Plexiform Neurofibroma: The Unusual Presentations and Surgical Challenges

Cureus, 2022
Neurofibromatosis type one (NF-1) is an autosomal dominant neurocutaneous disorder also known as Von Recklinghausen disease. Plexiform neurofibroma is a rare kind of NF-1 where the neurofibroma originates from nerve sheath cells or subcutaneous ...
Hui Yuan Lam, Shawaltul Akhma Harun Nor Rashid   +1 more
semanticscholar   +1 more source