Results 41 to 50 of about 3,865 (164)

Mediastinal mass in an tuberculosis-exposed 2-year old child with neurofibromatosis type 1 – TB or not TB?

Respiratory Medicine Case Reports, 2021
A toddler with neurofibromatosis type 1 (NF1) was evaluated for tuberculosis (TB) after exposure. Chest X-ray (CXR) revealed a mediastinal mass indicating lymphadenopathy. However, magnetic resonance imaging showed a large plexiform thoracic neurofibroma.
Renate Krüger, Cornelia Potratz, Pablo Hernáiz-Driever, Birgit Lala, Cornelia Feiterna-Sperling   +4 more
doaj   +1 more source

Selumetinib as a Target Therapy in Progressive Paediatric Low‐Grade Gliomas—Case Series (pLGG)

Journal of Paediatrics and Child Health, Volume 62, Issue 8, Page 1499-1508, August 2026.
ABSTRACT Background Optic pathway gliomas (OPGs) occur in 15%–20% of children with neurofibromatosis type 1 (NF1). While smaller gliomas may be only monitored, the current standard of care for symptomatic ones relies on chemotherapy, most commonly carboplatin and vincristine.
Laura Trapani, Giulia Gortani, Andrea Magnolato, Flora Maria Murru, Elisabetta Cattaruzzi, Laura Diplotti, Paola Michieletto, Silvia Giganti, Davide Zanon, Alessandra Maestro, Valentina Kiren, Egidio Barbi, Irene Bruno   +12 more
wiley   +1 more source

Bilateral Giant Plexiform Neurofibromas In Neurofibromatosis Type 1

Indian Journal of Dermatology, 2002
A single plexiform neurofibroma or two of any type are considered diagnostic of neurofibromatosis type 1 (NF). Plexiform neurofibromas are congenital and pathognomonic for NF-1.
Thappa D . M, Jeevankumar B, Karthikeyan K   +2 more
doaj  

Ancient Schwannoma in the Nasal Cavity—A Rare Case Report With Brief Literature Review

Eye &ENT Research, EarlyView.
Shikhar Chohan, Annmy Jose, Sufian Zaheer   +2 more
wiley   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Cutaneous Adverse Drug Reactions Associated With BRAF and MEK Inhibitors: A Real‐World Analysis of WHO Pharmacovigilance Data

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 274-285, July 2026.
BRAF inhibitors and MEK inhibitors (MEKi) have reshaped the treatment of BRAFV600‐mutant malignancies; however, cutaneous adverse drug reactions (ADRs) remain a frequent and clinically impactful toxicity. Although clinical trials provide insight into their safety profiles, real‐world data on dermatologic ADRs are limited.
Natalia Sauer, Piotr Giedziun, Jacek Calik, Anna Wiela‐Hojeńska   +3 more
wiley   +1 more source

Facial plexiform neurofibroma in a child with neurofibromatosis type I: A case report

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2007
Plexiform neurofibroma is a non-circumscribed, thick, and irregular benign tumor of the peripheral nerve sheath. It is a virtually pathognomonic and often disabling feature of neurofibromatosis type I.
Patil K, Mahima V, Shetty S, Lahari K
doaj  

Cardiac overload resolved by resection of a large plexiform neurofibroma on both the buttocks and upper posterior thighs in a patient with neurofibromatosis type I: a case report

BMC Surgery, 2020
Background A large plexiform neurofibroma in patients with neurofibromatosis type I can be life threatening due to possible massive bleeding within the lesion.
Taro Mikami, Yuki Honma-Koretsune, Yui Tsunoda, Shintaro Kagimoto, Yuichiro Yabuki, Jiro Maegawa, Takashi Terauchi, Shintaro Nawata, Hiroyuki Kamide, Yoshinobu Ishiwata, Tabito Kino, Teruyasu Sugano   +11 more
doaj   +1 more source

Metastatic Testicular Germ Cell Tumor in a Patient With Neurofibromatosis Type 1: Treatment With Trametinib Based on NF1 Gene Mutation

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Neurofibromatosis type 1 (NF1) is a genetic disorder that increases the risk of various tumors. However, its association with testicular germ cell tumors (GCTs) is rare. We report a case of metastatic GCT in an NF1 patient treated with precision medicine.
Keita Goto, Toshiki Kijima, Yusuke Sato, Kousuke Watanabe, Hidenori Kage, Katsutoshi Oda, Tatsunori Shimoi, Kazuyuki Ishida, Haruki Kume, Takao Kamai   +9 more
wiley   +1 more source

Solitary Nodule in the Hard Palate

Oral Diseases, EarlyView.
Sara Lia Gonçalves de Lima, Poliana Soares Cruz, Maria Gabriela Candido Dias, Láysa Tavares de Melo, Laura Maria dos Santos Reis Rocha de Castro, Felipe Paiva Fonseca, Brunno Santos de Freitas Silva   +6 more
wiley   +1 more source