Results 31 to 40 of about 7,465 (255)

Gender dimorphism and age of onset in malignant peripheral nerve sheath tumor preclinical models and human patients. [PDF]

, 2014
BackgroundGender-based differences in disease onset in murine models of malignant peripheral nerve sheath tumor (MPNST) and in patients with Neurofibromatosis type-1-(NF-1)-associated or spontaneous MPNST has not been well studied.MethodsForty-three ...
Dry, Sarah M, Eilber, Fritz C, Federman, Noah, Li, Yunfeng, Nakashima, Jonathan, Shurell, Elizabeth, Smith, Kathleen B, Tam, Brenna M, Tap, William D, Tran, Linh M, Wu, Hong   +10 more
core   +2 more sources

Lumbar plexiform neurofibroma, short stature, and kyphoscoliosis in neurofibromatosis-1: A Rare entity

Sahel Medical Journal, 2019
The incidence of neurofibromatosis (NF), comprising NF-1 and NF-2, seems to be rising in Nigeria. The features of NF-1 have not been completely identified in the country.
Ernest Ndukaife Anyabolu
doaj   +1 more source

Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1. [PDF]

, 2018
Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in Neurofibromin 1 (NF1). NF1 patients present with a variety of clinical manifestations and are predisposed to cancer development.
Carlson, Daniel F, Coutts, Alexander W, Dahiya, Sonika, Dombi, Eva, Fahrenkrug, Scott C, Fisher, James, Giovannini, Marco, Gutmann, David H, Isakson, Sara H, Kirstein, Mark N, Largaespada, David A, Messiaen, Ludwine, Moertel, Christopher L, Pluhar, G Elizabeth, Ratner, Nancy, Rizvi, Tilat, Rizzardi, Anthony E, Stemmer-Rachamimov, Anat O, Vitte, Jeremie, Watson, Adrienne L, Widemann, Brigitte C, Williams, Kyle B   +21 more
core   +2 more sources

Synchronous plexiform neurofibroma in the arytenoids and neurofibroma in the parapharynx in a patient with non-neurofibromatosis: a case report

Journal of Medical Case Reports, 2013
Introduction Plexiform neurofibroma of the larynx is a rare disease. In this report, we present a plexiform neurofibroma in the arytenoids and neurofibroma in the parapharynx detected coincidently.
Son Hee Young, Shim Hyun Seok, Kim Jin Pyeong, Woo Seung Hoon   +3 more
doaj   +1 more source

Malignant Transformation of Plexiform Neurofibroma Due to Neglected Giant Soft Tissue Swelling of the Back: A Case Report. [PDF]

Cureus
Bin Abdul Halim WMA, Bin Mat Hassan S, Bt Awang M, Abdullah MAH.   +3 more
europepmc   +3 more sources

Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1. [PDF]

, 2015
Background: Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to formation of benign neurofibromas, peripheral nerve tumors that can be associated with significant morbidity. Loss of the NF1 Ras-GAP protein causes
Cripe, Timothy P., Dombi, Eva, Dunn, Richard S., Janhofer, David, Jones, David R., Jousma, Edwin, Kim, Mi-Ok, Masters, Andrea R., Ratner, Nancy, Rizvi, Tilat A., Wu, Jianqiang   +10 more
core   +1 more source

Arteriovenous malformation underlying a plexiform neurofibroma: An unusual presentation

Indian Dermatology Online Journal, 2017
Vascular abnormalities associated with neurofibromatosis type 1 are well described in the literature, however, arteriovenous malformation is a very rare finding in neurofibromatosis type 1.
Zaheer Abbas, Sepideh Khani, Javad Zare
doaj   +1 more source

Preclinical Evidence for the Use of Sunitinib Malate in the Treatment of Plexiform Neurofibromas [PDF]

, 2015
Plexiform neurofibromas (pNF) are pathognomonic nerve and soft tissue tumors of neurofibromatosis type I (NF1), which are highly resistant to conventional chemotherapy and associated with significant morbidity/mortality.
Chen, Shi, Clapp, D. Wade, Ferguson, Michael J., Hutchins, Gary, Ingram, David A., Jiang, Li, Li, Xiaohong, Rhodes, Steven D., Territo, Paul, Vakili, Saeed T., Yang, Feng-Chun, Yang, Xianlin, Yuan, Jin, Zhang, Shaobo   +13 more
core   +1 more source

A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies [PDF]

, 2017
Preclinical studies using genetically engineered mouse models (GEMM) have the potential to expedite the development of effective new therapies; however, they are not routinely integrated into drug development pipelines. GEMMs may be particularly valuable
Braun, Benjamin S., Cichowski, Karen, Clapp, D. Wade, Cripe, Timothy P., De Raedt, Thomas, Epstein, Inbal, Huang, Tannie Q., Lauchle, Jennifer O., Lee, Hyerim, Maertens, Ophélia, McCurrach, Mila E., Ratner, Nancy, Shannon, Kevin, Wu, Jianqiang   +13 more
core   +1 more source

Retroperitoneal Malignant Peripheral Nerve Sheath Tumour: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2015
Malignant nerve sheath tumours (MPNST) are rare neoplasias and retroperitoneal cases are fairly rare and clinically difficult to be detected, but they are very agressive neoplasias. MPNST are frequently seen in head, neck and upper extremities.
Ayse Nur Deger, Mehmet Akif Bayar, Muzaffer Caydere, Hakki Deger, Mahir Tayfur   +4 more
doaj   +1 more source