Results 21 to 30 of about 29,620 (204)

Plexiform neurofibromas of bilateral brachial and lumbosacral plexuses

Apollo Medicine, 2022
Plexiform neurofibroma is a peripheral nerve sheath tumor that involves multiple nerve fascicles or nerve branches and is considered to be pathognomic of neurofibromatosis type-1.
S Sheetal, S Vijayalekshmi, Aswathy Sasidharan, N Jisa Merin Joy   +3 more
doaj   +1 more source

Superimposed Mosaicism in the Form of Extremely Extended Segmental Plexiform Neurofibroma Caused by a Novel Pathogenic Variant in the NF1 Gene

International Journal of Molecular Sciences, 2023
Plexiform neurofibromas occurring in approximately 20–50% of all neurofibromatosis type-1 (NF1) cases are histologically benign tumors, but they can be fatal due to compression of vital structures or transformation to malignant sarcomas or malignant ...
K. Veres, J. Bene, K. Hadzsiev, M. Garami, Sára Pálla, R. Happle, M. Medvecz, Z. Szalai   +7 more
semanticscholar   +1 more source

Plexiform neurofibroma of the scalp with bony defect: A case report and review of literature

Journal of Pediatric Surgery Case Reports, 2022
Plexiform neurofibroma (PNF) of the scalp is a very rare lesion. It is commonly associated with neurofibromatosis (NF 1). Occipital location of plexiform neurofibroma is even more infrequent.
Ram Jeewan Singh, Bijay Kumar Suman, Shreyas Dudhani, Sourav Jana, Amit Kumar Sinha, Bindey Kumar   +5 more
doaj   +1 more source

The Plexiform Neurofibroma Microenvironment [PDF]

Cancer Microenvironment, 2012
Dynamic interactions between tumorigenic cells and surrounding cells, including immunomodulatory hematopoietic cells, can dictate tumor initiation, progression, and transformation. Hematopoietic-stromal interactions underpin the plexiform neurofibroma, a debilitating tumor arising in individuals afflicted with Neurofibromatosis type 1 (NF1), a common ...
Feng-Chun, Yang, Karl, Staser, D Wade, Clapp   +2 more
openaire   +2 more sources

Clinical and humanistic burden among pediatric patients with neurofibromatosis type 1 and plexiform neurofibroma in the USA

Child's Nervous System, 2022
To assess clinical and humanistic burden among pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibroma (PN) in the USA. NF1-PN patients aged 8–18 years (treatment-naïve or ≤ 1 month of selumetinib treatment) and their caregivers
Xiaoqin Yang, H. Yoo, S. Amin, W. Cheng, S. Sundaresan, Lujia Zhang, M. Duh   +6 more
semanticscholar   +1 more source

Selumetinib in Children with Neurofibromatosis Type 1 and Asymptomatic Inoperable Plexiform Neurofibroma At Risk for Developing Tumor-Related Morbidity.

Neuro-Oncology, 2022
BACKGROUND Selumetinib was recently approved for treatment of inoperable symptomatic plexiform neurofibromas (PNs) in children with neurofibromatosis type 1 (NF1).
A. Gross, Brittany Glassberg, P. Wolters, E. Dombi, A. Baldwin, Michael Fisher, AeRang Kim, M. Bornhorst, B. Weiss, J. Blakeley, P. Whitcomb, S. Paul, S. Steinberg, D. Venzon, Staci Martin, A. Carbonell, Kara Heisey, Janet Therrien, O. Kapustina, Anne Dufek, J. Derdak, Malcolm A. Smith, B. Widemann   +22 more
semanticscholar   +1 more source

A Case Series of Plexiform Neurofibroma: The Unusual Presentations and Surgical Challenges

Cureus, 2022
Neurofibromatosis type one (NF-1) is an autosomal dominant neurocutaneous disorder also known as Von Recklinghausen disease. Plexiform neurofibroma is a rare kind of NF-1 where the neurofibroma originates from nerve sheath cells or subcutaneous ...
Hui Yuan Lam, Shawaltul Akhma Harun Nor Rashid   +1 more
semanticscholar   +1 more source

Efficacy and Safety of Trametinib in Neurofibromatosis Type 1-Associated Plexiform Neurofibroma and Low-Grade Glioma: A Systematic Review and Meta-Analysis

Pharmaceuticals, 2022
Trametinib has been used in neurofibromatosis type 1 (NF1) patients, especially those with unresectable nerve tumors, but no systematic review based on the latest studies has been published.
Dun Wang, Lingling Ge, Zizhen Guo, Yuehua Li, Bei-Bei Zhu, W. Wang, Chengjiang Wei, Qingfeng Li, Zhichao Wang   +8 more
semanticscholar   +1 more source

Isolated Plexiform Neurofibroma of Arm with Unusual Presentation - A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2015
Plexiform neurofibroma (PNF) arises as a diffuse mass from nerve trunk and leads to overgrowth of cutis and subcutis structure. This is a case report of 20-year-old male, presented to our hospital with a giant ulcerated swelling over his left arm ...
PANKAJ KUMAR MISHRA, RISHI DWIVEDI, DINESH CHANDRA SHRIVASTAVA, SURESH CHANDRA GAUR   +3 more
doaj   +1 more source

Plexiform Neurofibroma: A Case Report

SAS Journal of Surgery, 2021
Plexiform neurofibroma is a characteristic lesion of Von's disease Recklinghausen. Currently, surgery is the only effective treatment. This is difficult form due to its hemorrhagic nature and the pervasive appearance of the lesions.
D. Adil, Diher Issam, Ahmar-Rass Nour El Imane, Daghouri Nada- Imane, Taybi Otmane, Labbaci Rim   +5 more
semanticscholar   +1 more source