Results 21 to 30 of about 31,395 (237)

A Fibroblast-Derived Secretome Stimulates the Growth and Invasiveness of 3D Plexiform Neurofibroma Spheroids. [PDF]

Cancers (Basel)
Simple Summary Plexiform neurofibromas in neurofibromatosis type 1 (pNF1), characterized by aggressive growth and local invasiveness, are comprised primarily of Schwann cell-derived tumor cells (Nf1−/−) and the tumor microenvironment (TME).
Ji K, Schwenkel GJ, Mattingly RR, Sundararaghavan HG, Zhang ZG, Chopp M.   +5 more
europepmc   +2 more sources

Efficacy and Safety of Trametinib in Neurofibromatosis Type 1-Associated Plexiform Neurofibroma and Low-Grade Glioma: A Systematic Review and Meta-Analysis

Pharmaceuticals, 2022
Trametinib has been used in neurofibromatosis type 1 (NF1) patients, especially those with unresectable nerve tumors, but no systematic review based on the latest studies has been published.
Dun Wang, Lingling Ge, Zizhen Guo, Yuehua Li, Bei-Bei Zhu, W. Wang, Chengjiang Wei, Qingfeng Li, Zhichao Wang   +8 more
semanticscholar   +1 more source

Plexiform Neurofibroma: A Case Report

SAS Journal of Surgery, 2021
Plexiform neurofibroma is a characteristic lesion of Von's disease Recklinghausen. Currently, surgery is the only effective treatment. This is difficult form due to its hemorrhagic nature and the pervasive appearance of the lesions.
D. Adil, Diher Issam, Ahmar-Rass Nour El Imane, Daghouri Nada- Imane, Taybi Otmane, Labbaci Rim   +5 more
semanticscholar   +1 more source

Safety and efficacy of selumetinib in pediatric and adult patients with neurofibromatosis type 1 and plexiform neurofibroma. [PDF]

Neuro Oncol
Background The MEK inhibitor, selumetinib, reduces plexiform neurofibroma (PN) in pediatric patients with neurofibromatosis type 1 (NF1). Its safety and efficacy in adults with PN and effectiveness in other NF1 manifestations (eg, neurocognitive function,
Kim H, Yoon HM, Kim EK, Ra YS, Kim HW, Yum MS, Kim MJ, Baek JS, Sung YS, Lee SM, Lim HS, Lee BJ, Lim HT, Kim D, Yoon J, Bae H, Hwang S, Choi YH, Kim KA, Choi IH, Lee SW, Park SJ, Lee BH.   +22 more
europepmc   +2 more sources

Isolated Plexiform Neurofibroma of Arm with Unusual Presentation - A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2015
Plexiform neurofibroma (PNF) arises as a diffuse mass from nerve trunk and leads to overgrowth of cutis and subcutis structure. This is a case report of 20-year-old male, presented to our hospital with a giant ulcerated swelling over his left arm ...
PANKAJ KUMAR MISHRA, RISHI DWIVEDI, DINESH CHANDRA SHRIVASTAVA, SURESH CHANDRA GAUR   +3 more
doaj   +1 more source

Challenging Management of Plexiform Schwannoma and Plexiform Neurofibroma

The Journal of craniofacial surgery (Print), 2021
Plexiform variants of neurofibromas and schwannomas are rare and typically arise in superficial soft tissues in the head and neck region. The treatment of these tumors is challenging and no generally accepted guidelines exist for their optimal management.
T. Nicoli, R. Saat, J. Tarkkanen, I. Kinnunen, A. Mäkitie, J. Jero   +5 more
semanticscholar   +1 more source

Isolated plexiform neurofibroma over left palm: A case report and review of literature

Indian Journal of Dermatology, 2013
Plexiform neurofibroma is common over the branches of trigeminal and cervical nerves over the face. Plexiform neurofibroma over palm is rare and affects the individuals with fine motor functions of hand.
Mohan H Kudur, Manjunath Hulmani
doaj   +1 more source

Facial Plexiform Neurofibroma as an Intraparotid Nodule: A Rare Case Presentation

An International Journal of Otorhinolaryngology Clinics, 2021
Neurofibromas of salivary gland are very rare and account for only 0.4% of all salivary gland neoplasms. Plexiform type of neurofibromas are predominantly seen in a scenario of neurofibromatosis-1 (NF-1) association, but solitary plexiform neurofibroma ...
N. Afroz, Divya Rabindranath, R. Sherwani, S. Quadri   +3 more
semanticscholar   +1 more source

Lumbar plexiform neurofibroma, short stature, and kyphoscoliosis in neurofibromatosis-1: A Rare entity

Sahel Medical Journal, 2019
The incidence of neurofibromatosis (NF), comprising NF-1 and NF-2, seems to be rising in Nigeria. The features of NF-1 have not been completely identified in the country.
Ernest Ndukaife Anyabolu
doaj   +1 more source

Congenital Craniofacial Plexiform Neurofibroma in Neurofibromatosis Type 1

Diagnostics, 2021
We present a case demonstrating the performance of different radiographical imaging modalities in the diagnostic work-up of a patient with neurofibromatosis type 1 (NF1) and plexiform neurofibroma (PN).
A. Cacchione, A. Carboni, M. Lodi, R. Vito, A. Carai, A. Marrazzo, M. Macchiaiolo, I. P. Voicu, A. Mastronuzzi, G. Colafati   +9 more
semanticscholar   +1 more source