Results 21 to 30 of about 27,651 (232)

SUCLG1 promotes aerobic respiration and progression in plexiform neurofibroma. [PDF]

Int J Oncol
Zhou Z, Li Q, Huo R.
europepmc   +3 more sources

A case report of a 4-year-old girl with neurofibromatosis type 1

Cancer Treatment and Research Communications, 2022
Neurofibromatosis type 1 is a rare genetic disorder, which is a benign nerve tumor resulting from aberrant growth of the cells of nerve sheath. NF1 patients were associated with multisystem involvement, characterized by neurofibroma, of which 50% were ...
Mengying Peng, Yuqing Zhang, Qiong Zhou
doaj   +1 more source

Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage

Journal of Pharmacology and Experimental Therapeutics, 2023
Individuals with neurofibromatosis type 1 develop rat sarcoma virus (RAS)–mitogen-activated protein kinase–mitogen-activated and extracellular signal-regulated kinase (RAS-MAPK-MEK)–driven nerve tumors called neurofibromas.
Mark Jackson, Niousha Ahmari, Jianqiang Wu, T. Rizvi, E. Fugate, Mi-Ok Kim, E. Dombi, Heribert Arnhof, G. Boehmelt, M. Düchs, Clive J Long, U. Maier, F. Trapani, M. H. Hofmann, N. Ratner   +14 more
semanticscholar   +1 more source

Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma.

Clinical Cancer Research, 2023
PURPOSE Plexiform neurofibromas (PNF) are peripheral nerve sheath tumors that cause significant morbidity in persons with neurofibromatosis type 1 (NF1), yet treatment options remain limited.
Alyssa C Flint, Dana K. Mitchell, Steve Angus, A. Smith, Waylan K Bessler, Li Jiang, H. Mang, Xiaohong Li, Qingbo Lu, B. Rodriguez, G. Sandusky, A. Masters, Chi Zhang, Pengtao Dang, Jenna K. Koenig, Gary L. Johnson, W. Shen, Jiangang Liu, A. Aggarwal, Gregory P. Donoho, Melinda D Willard, S. Bhagwat, D. Clapp, Steven D. Rhodes   +23 more
semanticscholar   +1 more source

Superimposed Mosaicism in the Form of Extremely Extended Segmental Plexiform Neurofibroma Caused by a Novel Pathogenic Variant in the NF1 Gene

International Journal of Molecular Sciences, 2023
Plexiform neurofibromas occurring in approximately 20–50% of all neurofibromatosis type-1 (NF1) cases are histologically benign tumors, but they can be fatal due to compression of vital structures or transformation to malignant sarcomas or malignant ...
K. Veres, J. Bene, K. Hadzsiev, M. Garami, Sára Pálla, R. Happle, M. Medvecz, Z. Szalai   +7 more
semanticscholar   +1 more source

Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment

JCI Insight, 2022
To define alterations early in tumor formation, we studied nerve tumors in neurofibromatosis 1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas, benign tumors driven by NF1 loss in Schwann cells (SCs).
Leah J. Kershner, Kwangmin Choi, Jianqiang Wu, Xiyuan Zhang, Melissa R. Perrino, N. Salomonis, J. Shern, N. Ratner   +7 more
semanticscholar   +1 more source

Plexiform neurofibromas of bilateral brachial and lumbosacral plexuses

Apollo Medicine, 2022
Plexiform neurofibroma is a peripheral nerve sheath tumor that involves multiple nerve fascicles or nerve branches and is considered to be pathognomic of neurofibromatosis type-1.
S Sheetal, S Vijayalekshmi, Aswathy Sasidharan, N Jisa Merin Joy   +3 more
doaj   +1 more source

Clinical and humanistic burden among pediatric patients with neurofibromatosis type 1 and plexiform neurofibroma in the USA

Child's Nervous System, 2022
To assess clinical and humanistic burden among pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibroma (PN) in the USA. NF1-PN patients aged 8–18 years (treatment-naïve or ≤ 1 month of selumetinib treatment) and their caregivers
Xiaoqin Yang, H. K. Yoo, S. Amin, W. Cheng, S. Sundaresan, Lujia Zhang, M. Duh   +6 more
semanticscholar   +1 more source

Plexiform neurofibroma of the scalp with bony defect: A case report and review of literature

Journal of Pediatric Surgery Case Reports, 2022
Plexiform neurofibroma (PNF) of the scalp is a very rare lesion. It is commonly associated with neurofibromatosis (NF 1). Occipital location of plexiform neurofibroma is even more infrequent.
Ram Jeewan Singh, Bijay Kumar Suman, Shreyas Dudhani, Sourav Jana, Amit Kumar Sinha, Bindey Kumar   +5 more
doaj   +1 more source

Malignant Transformation of Plexiform Neurofibroma Due to Neglected Giant Soft Tissue Swelling of the Back: A Case Report. [PDF]

Cureus
Bin Abdul Halim WMA, Bin Mat Hassan S, Bt Awang M, Abdullah MAH.   +3 more
europepmc   +3 more sources