Spatiotemporal release of VEGF from biodegradable polylactic-co-glycolic acid microspheres induces angiogenesis in chick chorionic allantoic membrane assay [PDF]
, 2019 The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.While vascular endothelial growth factor (VEGF) is an acknowledged potent pro-angiogenic agent there is a ...
Bullock, Anthony J. +3 more
core +1 more source
British Journal of Pharmacy, 2019 The main objective of this work was to formulate novel amphiphilic PLGA nanoparticles with improved physicochemical properties for the delivery of the novel peptide (CK-10) to be used for targeting of the cancerous/tumour tissue.
Ahmed M Faheem +3 more
doaj +1 more source
British Journal of Pharmacy, 2019 Ran is a small RAS-related GTPase and is overexpressed in breast carcinoma to induce malignant transformation and metastatic growth. A novel series of antiRan-GTPase peptide (CK-10), which inhibits Ran hydrolysis and activation, have suboptimal activity ...
Ahmed M Faheem +3 more
doaj +1 more source
Porous polymer coatings on metal microneedles for enhanced drug delivery [PDF]
Royal Society Open Science, 2018 We present a simple method to coat microneedles (MNs) uniformly with a porous polymer (PLGA) that can deliver drugs at high rates. Stainless steel (SS) MNs of high mechanical strength were coated with a thin porous polymer layer to enhance their delivery
Asad Ullah, Chul Min Kim, Gyu Man Kim
doaj +1 more source
Using 5-fluorouracil-encored plga nanoparticles for the treatment of colorectal cancer: the in-vitro characterization and cytotoxicity studies [PDF]
Nanomedicine Journal, 2020 Objective(s): Colorectal cancer (CRC) is a prevalent cancer worldwide. The present study aimed to synthesize and investigate the potential of wheat germ agglutinin (WGA) conjugated with polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) incorporating
Aditya Nath Pandey +2 more
doaj +1 more source
Encapsulation of human serum albumin in submicrometer magnetic poly(lactide-co-glycolide) particles as a model system for targeted drug delivery [PDF]
, 2013 Two types of iron oxide nanoparticles were synthesized by coprecipitation of Fe(II) and Fe(III) chlorides: water-dispersible γ-Fe2O3 and organic solvent-dispersible oleic acid-coated Fe3O4 particles.
Feczkó, Tivadar +6 more
core +1 more source
Development of a targeted and controlled nanoparticle delivery system for FoxO1 inhibitors [PDF]
, 2020 Background: Poly (lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) are polymers approved by the United States’ Food and Drug Administration.
Cheng, Zhiyong +5 more
core +1 more source
Treating Macrophages with Anti-inflammatory Nanoparticles as a Strategy to Improve Muscle Repair [PDF]
, 2019 The macrophage is an immune cell that is involved in host defense. More recent research, however, has revealed that they also play a central role in mediating the skeletal muscle regenerative process.
Yan, Derek
core +1 more source
Multi-layer PLGA-pullulan-PLGA electrospun nanofibers for probiotic delivery
Food Hydrocolloids, 2022 Abstract Encapsulation of bacteria into a polymer matrix can potentially enhance the delivery of probiotics. In this study, we present a multilayer electrospun construct to facilitate enhanced delivery of probiotics, where the internal layer is loaded with bacterial cells and the external layers sandwich the internal layer for increased protection ...
Fatemeh Ajalloueian +6 more
openaire +2 more sources
A perfusion culture system for assessing bone marrow stromal cell differentiation on PLGA scaffolds for bone repair [PDF]
, 2018 Biomaterials development for bone repair is currently hindered by the lack of physiologically relevant in vitro testing systems. Here we describe the novel use of a bi-directional perfusion bioreactor to support the long term culture of human bone marrow
Alini, Mauro +5 more
core +2 more sources