Advanced Healthcare Materials, EarlyView.We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin +5 more
wiley +1 more source
Cogent Medicine, 2016 Effective and sustained release formulations of antimetabolite 5-Flurouracil (5Fu) for ocular fibrosis are highly desirable for success of glaucoma filtration surgery (GFS).
Meghali Bora +4 more
doaj +1 more source
PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study
Pharmaceutics, 2020 The treatment of diseases that affect the central nervous system (CNS) represents a great research challenge due to the restriction imposed by the blood−brain barrier (BBB) to allow the passage of drugs into the brain.
Gina P. Hoyos-Ceballos +11 more
doaj +1 more source
Efficacy of the Biomaterials 3 wt%-nanostrontium-hydroxyapatite-enhanced Calcium Phosphate Cement (nanoSr-CPC) and nanoSr-CPC-incorporated Simvastatin-loaded Poly(lactic-co-glycolic-acid) Microspheres in Osteogenesis Improvement [PDF]
, 2016 Aims The purpose of this multi-phase explorative in vivo animal/surgical and in vitro multi-test experimental study was to (1) create a 3 wt%-nanostrontium hydroxyapatite-enhanced calcium phosphate cement (Sr-HA/CPC) for increasing bone formation and (2)
Masaeli, Reza +12 more
core +1 more source
Anticancer activity of rutin and its combination with ionic liquids on renal cells [PDF]
, 2020 The renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel and more effective therapies, while minimizing toxicity, continues to be fundamental in curtailing RCC.
Araújo, Maria Eduarda Machado +6 more
core +1 more source
PLGA‐PEG‐PLGA Polymer: From Synthesis to Advanced Pharmaceutical Applications
Advances in Polymer TechnologyThis paper presents an in‐depth analysis of the PLGA‐PEG‐PLGA polymer, focusing on its synthesis and applications in advanced drug delivery systems (DDSs). PLGA‐PEG‐PLGA, a triblock copolymer, gains attention due to its biodegradability, biocompatibility, and thermosensitive properties, making it suitable for encapsulating both hydrophilic and ...
Bartosz Strus, Arkadiusz Szterk
openaire +2 more sources
Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review
Advanced Healthcare Materials, EarlyView.Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami +4 more
wiley +1 more source
Designed Monomers and Polymers, 2021 The objective of this paper was to develop a PLGA carrier Ticagrelor sustained-release microspheres preparation, which was expected to continue to release Ticagrelor for 14 days with a high encapsulation rate.
Linkun Hao +6 more
doaj +1 more source
\u3cem\u3eIn vitro\u3c/em\u3e Effect of Graphene Structures as an Osteoinductive Factor in Bone Tissue Engineering: A Systematic Review [PDF]
, 2018 Graphene and its derivatives have been well‐known as influential factors in differentiating stem/progenitor cells toward the osteoblastic lineage. However, there have been many controversies in the literature regarding the parameters effect on bone ...
Golzar, Hossein +7 more
core +1 more source
Unbreakable codes in electrospun fibers : digitally encoded polymers to stop medicine counterfeiting [PDF]
, 2010 Fluorescent polymer solutions can easily be electrospun into micrometer-sized fibers and subsequently encoded with long lasting digital codes by a photobleaching process.
Braeckmans, Kevin +9 more
core +2 more sources