Results 91 to 100 of about 36,442 (241)

The consequences of partial clonality on the spatiotemporal genetic structure of the red alga Chondria tumulosa (Ceramiales, Rhodophyta)

Journal of Phycology, EarlyView.
Abstract The relative rates of sexual versus clonal reproduction partition genetic diversity, but the quantification of these rates remains limited in natural populations. This knowledge gap is particularly acute among tropical macroalgae. Chondria tumulosa is a red macroalga that has been documented at high abundance in the three northernmost atolls ...
Taylor M. Williams, Heather L. Spalding, Solenn Stoeckel, Brian B. Hauk, Jonathan Plissner, Randall K. Kosaki, Stacy A. Krueger‐Hadfield   +6 more
wiley   +1 more source

Exploring the intratumoral heterogeneity of DNA ploidy in prostate cancer

Cancer Reports
Background Prostate cancer is morphologically and molecularly heterogeneous. Genomic heterogeneity might be mirrored by variability in DNA ploidy. Aneuploidy is a hallmark of genomic instability and associated with tumor aggressiveness.
Tatjana Vlajnic, David C. Müller, Christian Ruiz, René Schönegg, Hans‐Helge Seifert, George N. Thalmann, Tobias Zellweger, Clémentine Le Magnen, Cyrill A. Rentsch, Lukas Bubendorf   +9 more
doaj   +1 more source

Linking variation in genome size to cyst size in chrysophytes

Journal of Phycology, EarlyView.
Abstract Genome size varies tremendously across eukaryotes, which often contain far more DNA than expected from their biological complexity. To explain this paradox, selection‐based hypotheses propose that genome size evolves through selection acting on life‐history traits correlated with the phenotypic effects, independent of its genic content.
Natálie Protić, Iva Jadrná, Pavel Škaloud, Petr Knotek, Dora Čertnerová   +4 more
wiley   +1 more source

Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA

Advanced Science
Most gene therapies exert their actions via manipulation of hepatocytes (parenchymal cells) and the reasons behind the suboptimal performance of synthetic mRNA in non‐parenchymal cells (NPC) such as Kupffer cells (KC), and liver macrophages, remain ...
Cheng Lin, Adrian Kuzmanović, Nan Wang, Liangliang Liao, Sabrina Ernst, Christian Penners, Alexander Jans, Thomas Hammoor, Petra Bumnuri Stach, Mona Peltzer, Ines Volkert, Elisabeth Zechendorf, Reham Hassan, Maiju Myllys, Christian Liedtke, Andreas Herrmann, Gurudas Chakraborty, Christian Trautwein, Jan Hengstler, Gerhard Müller‐Newen, Junqing Wang, Ahmed Ghallab, Matthias Bartneck   +22 more
doaj   +1 more source

Cross‐ploidy hybridisation in Alpine woodrushes is associated with ecological additivity and scale‐dependent niche divergence

New Phytologist, EarlyView.
Genetic differentiation among the study species. Summary Hybridisation and whole‐genome duplication (WGD) are widespread in plants, yet their ecological consequences remain challenging to predict. In allopolyploids, where both processes coincide, ecological divergence is typically evaluated against a null hypothesis of ecological additivity.
Valentin Heimer, Peter Schönswetter, Božo Frajman   +2 more
wiley   +1 more source

Divergent trajectories of genome architecture and chromosome evolution in ferns and angiosperms

New Phytologist, EarlyView.
Variation in key fern genomic traits across families, mapped onto a summary phylogenetic tree. Summary Ferns and angiosperms represent the two largest vascular plant lineages but exhibit striking genomic and ecological contrasts. We investigated whether differences in genome size, chromosome architecture, GC content, and stomatal traits reveal ...
Petr Bureš, Kateřina Vejvodová, František Zedek, Tammy L. Elliott, Pavel Veselý, Michaela Fajkusová, Lenka Holubářová, Jana Schwarzová, Petr Šmarda, Jakub Šmerda, Klára Panda, Vlastik Rybka, Harald Schneider, Ilia J. Leitch, Libor Ekrt   +14 more
wiley   +1 more source

Desiccation tolerance mechanisms in the green lineage and beyond

New Phytologist, EarlyView.
Ancient origin and recurrent evolution of desiccation tolerance in the green lineage. Summary Water is essential for life on Earth, yet some plants can survive the near‐complete loss of cellular water, a trait known as desiccation tolerance. Although rare in vegetative tissues of vascular plants, desiccation tolerance is scattered across the plant ...
Jenny Schuster, Robert VanBuren
wiley   +1 more source

The cold case of state transition 7 (stt7) mutants of Chlamydomonas reinhardtii, solved by whole‐genome sequencing

New Phytologist, EarlyView.
Long‐read whole‐genome sequencing revealed extensive chromosomal rearrangements and aneuploidy in a widely used Chlamydomonas reinhardtii stt7‐1 mutant. The STT7 gene (shown in red) was found to be split between two rearranged chromosomes, providing a molecular explanation for the long‐standing failure of this mutant in genetic crosses.
Sandrine Bujaldon, Adrien Burlacot, Frédéric Chaux, Francis‐André Wollman   +3 more
wiley   +1 more source

Revisiting the Molecular Roadmap for Sugar Crops: Genome Reading, Trait Writing and Variety Redesigning

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sugar crops, including but not limited to sugarcane, sugar beet, sweet sorghum and stevia, are major sources of sugar production in the world. However, conventional breeding approaches, limited by long breeding cycles, low efficiency and restricted capacity to improve complex traits in sugar crops, are increasingly insufficient to address the ...
Peilin Wang, Qibin Wu, Wenzhi Wang, Prakash Lakshmanan, Yangrui Li, Khushi Muhammad, Yuguang Wang, Youxiong Que   +7 more
wiley   +1 more source

Ploidy in cardiovascular development and regeneration

Seminars in Cell & Developmental Biology
Somatic polyploidy, a non-inheritable form of genome multiplication, plays cell-type specific and context-dependent roles in organ development and regeneration. In the mammalian heart, embryonic cardiomyocytes are primarily diploid, which lose their ability to complete cell division and become polyploid as they mature.
Tian Lan, Sabrina Kaminsky, Chi-Chung Wu
openaire   +2 more sources