Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes [PDF]
Scientific Reports, 2018 Growing evidence shows that improper intake of vitamin B6 increases cancer risk and several studies indicate that diabetic patients have a higher risk of developing tumors.
MF Fenech +69 more
core +3 more sources
BioMed Research International, 2014 The main focus of this special issue is on structural, functional, and biomedical studies on pyridoxal-5′-phosphate- (PLP-) dependent enzymes. The unparalleled catalytic versatility of PLP, the active form of vitamin B6, originates from its unique electron-sinking properties, which stabilize reaction intermediates, thus lowering the activation barrier ...
Paiardini A. +3 more
openaire +6 more sources
Correlation Between Anti-Myelin Proteolipid Protein (PLP) Antibodies and Disease Severity in Multiple Sclerosis Patients With PLP Response-Permissive HLA Types [PDF]
Frontiers in Immunology, 2020 The most prominent pathological features of multiple sclerosis (MS) are demyelination and neurodegeneration. The exact pathogenesis of MS is unknown, but it is generally regarded as a T cell-mediated autoimmune disease.
J. Greer, É. Trifilieff, M. Pender
semanticscholar +2 more sources
Liver Transplantation in PNPO Deficiency: Management Challenges and Biological Lessons [PDF]
JIMD ReportsPyridox(am)ine 5′ Phosphate Oxidase deficiency (PNPO) presents with refractory epilepsy responsive to treatment with pyridoxal 5′ phosphate (PLP) or pyridoxine.
Richard Webster +12 more
doaj +2 more sources
DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP) [PDF]
Journal of Neuroinflammation, 2012 Multiple sclerosis (MS) is associated with pathogenic autoimmunity primarily focused on major CNS-myelin target antigens including myelin basic protein (MBP), proteolipidprotein (PLP), myelin oligodendrocyte protein (MOG).
N. Kaushansky +4 more
semanticscholar +2 more sources
Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. [PDF]
Cell Death and Disease, 2013 NG2 (nerve/glial antigen2)-expressing cells represent the largest population of postnatal progenitors in the central nervous system and have been classified as oligodendroglial progenitor cells, but the fate and function of these cells remain ...
Chung, S-H +4 more
core +3 more sources
Proceedings of the VLDB Endowment, 2011 Scaling the performance of shared-everything transaction processing systems to highly-parallel multicore hardware remains a challenge for database system designers. Recent proposals alleviate locking and logging bottlenecks in the system, leaving page latching as the next potential problem.
Ippokratis Pandis +3 more
semanticscholar +3 more sources
Enhancing PLP-Binding Capacity of Class-III ω-Transaminase by Single Residue Substitution
Frontiers in Bioengineering and Biotechnology, 2019 Transaminases are pyridoxal-5′-phosphate (PLP) binding enzymes, broadly studied for their potential industrial application. Their affinity for PLP has been related to their performance and operational stability and while significant differences in PLP ...
David Roura Padrosa +7 more
doaj +2 more sources
Treatment of phantom limb pain (PLP) based on augmented reality and gaming controlled by myoelectric pattern recognition: a case study of a chronic PLP patient [PDF]
Frontiers in Neuroscience, 2014 A variety of treatments have been historically used to alleviate phantom limb pain (PLP) with varying efficacy. Recently, virtual reality (VR) has been employed as a more sophisticated mirror therapy.
M. Ortiz-Catalán +4 more
semanticscholar +2 more sources
Biology Open, 2015 Centrosomes comprise a pair of centrioles surrounded by a matrix of pericentriolar material (PCM). In vertebrate cells, Pericentrin plays an important part in mitotic PCM assembly, but the Drosophila Pericentrin-like protein (PLP) appears to have a more ...
Jennifer H. Richens +6 more
doaj +2 more sources