Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase. [PDF]
PLoS ONE, 2012 Pyridoxal 5'-phosphate (PLP) is a cofactor for dozens of B(6) requiring enzymes. PLP reacts with apo-B(6) enzymes by forming an aldimine linkage with the ε-amino group of an active site lysine residue, thus yielding the catalytically active holo-B(6 ...
Mohini S Ghatge +10 more
doaj +1 more source
Parkinson’s Disease: Carbidopa, Nausea, and Dyskinesia [Retraction]
Clinical Pharmacology: Advances and Applications, 2021 Hinz M, Stein A, Cole T. Clin Pharmacol. 2014;6:189–194.The Editor-in-chief and Publisher of Clinical Pharmacology: Advances and Applications wish to retract the published article.This perspective article cites several original ...
Hinz M, Stein A, Cole T
doaj
Physical Activity for the Treatment of Phantom Limb Pain [PDF]
Athens Journal of Health and Medical Sciences, 2023 Phantom limb pain (PLP) is a complex and multifactorial phenomenon whereby individuals with an amputation feel intermittent pain or discomfort where the limb used to be.
Ingrid Brenner +2 more
doaj +1 more source
A Cholesterol Analogue for Cell‐Surface Enzyme Display
Angewandte Chemie, EarlyView.We report a non‐genetic strategy for bacterial cell surface enzyme immobilisation using cholesterol‐based artificial lipids containing Ni2+‐NTA binding groups that can integrate into biological membranes. The engineered cells can capture His‐tagged enzymes directly from cell lysates while preserving intracellular and surface activity, allowing for ...
Vasco F. Batista +3 more
wiley +2 more sources
Facile immobilization of pyridoxal 5′-phosphate using p-diazobenzoyl-derivatized Sepharose 4B
Results in Chemistry, 2023 Pyridoxal 5′-phosphate (PLP) is a ubiquitous and versatile cofactor utilized by numerous enzymes involved in amino acid biosynthetic pathways. Immobilized PLP is a valuable tool to isolate unknown PLP-dependent enzymes in nature or to perform in vitro ...
Kun-Hwa Lee +2 more
doaj +1 more source
Discriminative Training Using Noise Robust Integrated Features and Refined HMM Modeling
Journal of Intelligent Systems, 2018 The classical approach to build an automatic speech recognition (ASR) system uses different feature extraction methods at the front end and various parameter classification techniques at the back end.
Dua Mohit +2 more
doaj +1 more source
Optimizing Integrated Features for Hindi Automatic Speech Recognition System
Journal of Intelligent Systems, 2018 An automatic speech recognition (ASR) system translates spoken words or utterances (isolated, connected, continuous, and spontaneous) into text format.
Dua Mohit +2 more
doaj +1 more source
Role of Proteolipid Protein in HSV-1 Entry in Oligodendrocytic Cells. [PDF]
PLoS ONE, 2016 Herpes simplex virus type 1 (HSV-1) has the ability to enter many different hosts and cell types by several strategies. This highly prevalent alphaherpesvirus can enter target cells using different receptors and different pathways: fusion at a neutral pH,
Raquel Bello-Morales +9 more
doaj +1 more source
Conformational change of organic cofactor PLP is essential for catalysis in PLP-dependent enzymes
BMB Reports, 2022 Pyridoxal 5’-phosphate (PLP)-dependent enzymes are ubiquitous, catalyzing various biochemical reactions of approximately 4% of all classified enzymatic activities. They transform amines and amino acids into important metabolites or signaling molecules and are important drug targets in many diseases.
Ho-Phuong-Thuy Ngo +8 more
openaire +1 more source
Parkinson’s Disease: Carbidopa, Nausea, and Dyskinesia [Expression of Concern]
Clinical Pharmacology: Advances and Applications, 2020 Hinz M, Stein A, Cole T. Clin Pharmacol Adv Appl. 2014;6:189–194. The Editor-in-Chief and Publisher of Clinical Pharmacology: Advances and Applications wish to issue an Expression of Concern for the published article.
Hinz M, Stein A, Cole T
doaj