Results 81 to 90 of about 85,442 (189)

The C2H2‐GGAT Regulatory Module Fine‐Tunes Glutamate Homeostasis to Improve Fruit Flavour and Enhance Disease Resistance in Peach

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3282-3295, May 2026.
ABSTRACT Free amino acids (FAAs) play a fundamental role in determining fruit quality and stress adaptation, yet their genetic regulation remains poorly understood. Through an integrated approach combining metabolomic and sensory analyses of 120 peach (Prunus persica) hybrids, we identified glutamate as a key metabolite linking FAA content to umami ...
Yike Su, Xiaojuan Yang, Chanyuan Wu, Xianyao Jin, Yuanyuan Zhang, Yuyan Zhang, Kunsong Chen, Mingliang Yu, Bo Zhang   +8 more
wiley   +1 more source

Biocatalytic Indigo Synthesis From L‐Tryptophan Using a Three‐Step Cascade Without Cofactor Regeneration

ChemBioChem, Volume 27, Issue 8, April 2026.
A self‐sufficient, NAD(P)H‐independent enzyme cascade for the synthesis of indigo from L‐tryptophan. The minimal cascade uses pyruvate, a byproduct of tryptophan cleavage, to generate hydrogen peroxide, which fuels the key hydroxylation of indole to indoxyl by an engineered tyrosine hydroxylase.
Vivian P. Willers, Nikola Lončar, Marco W. Fraaije   +2 more
wiley   +1 more source

Roll‐to‐Roll Manufacturing of Flexible Thermoelectric Semiconductors Using Low‐Level Direct‐Current Sputtering

Advanced Materials Technologies, Volume 11, Issue 8, 17 April 2026.
Roll‐to‐roll direct‐current sputtering enables room‐temperature manufacture of flexible bismuth telluride thermoelectric films. By identifying a low‐power deposition window that suppresses charge‐induced arcing, this work links sputtering conditions to film structure, charge transport, and thermoelectric performance, achieving a room‐temperature figure
Xudong Tao, John O'Sullivan, Kening Wan, Emiliano Bilotti, Ruy Sebastian Bonilla, Hazel E. Assender   +5 more
wiley   +1 more source

Workshop W01: PLP and PLP Mutants ‐ What's New? [PDF]

Journal of Neurochemistry, 2006
openaire   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, Volume 13, Issue 22, 17 April 2026.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Outstanding 1200 °C Oxidation Resistance in a Novel Multi‐Principal Element Alloy via Lattice Distortion‐Induced Diffusion Suppression

Advanced Science, Volume 13, Issue 20, 9 April 2026.
The unique lamellar structure of the eutectic alloy promotes selective oxidation of Al initially, while lattice distortion‐induced diffusion suppression slows oxide growth during steady state. Combining these strategies, a Multi‐Principal Element Alloy with excellent oxidation resistance at 1200℃ was designed.
Xinyu Zhang, Weiyan Lv, Xinguang Wang, Chuanmin Jia, Yizhou Zhou, Keqiang Qiu, Jianqiang Wang   +6 more
wiley   +1 more source

Infection of 5xFAD mice with a mouse‐adapted SARS‐CoV‐2 does not alter Alzheimer's disease neuropathology yet induces widespread changes in gene expression across diverse cell types

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The COVID‐19 pandemic underscored the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection on worsening the severity of Alzheimer's disease (AD) neuropathology and disease progression. METHODS Aged 5xFAD and wild‐type (WT) mice were infected with a mouse‐adapted SARS‐CoV‐2 (MA10), and extensive ...
Susana Furman, Latifa Zayou, Kate Inman Tsourmas, Dominic Ibarra Javonillo, Gema M. Olivarria, Yuting Cheng, Collin Pachow, Kellie Fernandez, Lucas Le, Robert A. Edwards, Dequina A. Nicholas, Gabriela Pacheco Sanchez, Ralph S. Baric, Kim N. Green, Thomas E. Lane   +14 more
wiley   +1 more source

Electroenzymatic Cascades for Nitrogen Upgrading: Beyond Ammonia Towards Value‐Added Nitrogen Chemicals

ChemCatChem, Volume 18, Issue 7, 14 April 2026.
This review maps how electroenzymatic cascades that couple nitrogen‐cycle enzymes with C─N bond forming auxilary enzymes, powered by direct electron transfer (DET) or mediated electron transfer (MET), can upgrade N2 and waste nitrogen streams into value‐added amines, amides, amino acids, and other nitrogen‐based chemicals.
Rohit G. Jadhav, Vamshi Krishna Kamaja, Wassim El Housseini, Monica Brachi, Shelley D. Minteer   +4 more
wiley   +1 more source

Ultraviolet association with vernal keratoconjunctivitis with perilimbal pigmentation. [PDF]

Int J Ophthalmol
Huang YM, BianBa DJ, Duan WF, Wang YX, Wu N.   +4 more
europepmc   +1 more source