Results 91 to 100 of about 24,895 (210)

Thyroid antibody positivity in pregnancy is associated with altered reproductive hormone concentrations and placental growth in Lewis rats

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid antibody positivity (TAb+) in pregnancy is associated with adverse pregnancy outcomes, but the mechanisms are unclear. This study developed a rodent model of TAb+ in pregnancy, induced prior to mating so that TAb+ exposure occurred throughout the pregnancy. TAb+ did not alter thyroid hormone concentrations and had minimal
Rebecca L. Brady, Nykola L. Kent, Anna G. Reid, Liana P. Paszkowski, Ashley S. Meakin, Dayna A. Zimmerman, Dinithi T. Mahaliyanage, Elliott S. Neal, Michael D. Wiese, Helle Bielefeldt‐Ohmann, Janna L. Morrison, James S. M. Cuffe   +11 more
wiley   +1 more source

Chemoenzymatic Synthesis of Chiral Piperidines Using the Immobilized Transaminase ATA‐117 in Continuous Flow Reactors

Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
A robust continuous flow chemoenzymatic process was developed for the stereoselective synthesis of cis‐(2R,6R)‐2,6‐disubstituted piperidines, including the natural alkaloid (–)‐pinidinone. The asymmetric transamination of α,β‐unsaturated ketones was catalyzed by immobilized ATA‐117, followed by spontaneous aza‐Michael cyclization, providing the desired
Sara Vicinanza, Ilaria Magrini Alunno, Stefania Patti, Morena Pirotta, Francesca Annunziata, Raffaella Gandolfi, Paola Conti, Chiara Borsari, Ivan Bassanini, Erica Elisa Ferrandi, Daniela Monti, Lucia Tamborini   +11 more
wiley   +1 more source

Do Acceptance‐ and Mindfulness‐Based Interventions Improve Psychological Flexibility in People With Chronic Pain? A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

European Journal of Pain, Volume 30, Issue 7, August 2026.
ABSTRACT Background Acceptance‐ and mindfulness‐based interventions are effective for improving pain‐related outcomes, yet their effects on psychological flexibility have not been meta‐analyzed. This systematic review and meta‐analysis addressed this gap by comparing these interventions with control conditions on psychological flexibility and its core ...
Juan P. Sanabria‐Mazo, Carla Rodríguez‐Freire, Estíbaliz Royuela‐Colomer, Paula Ponce‐López, Pablo Alonso‐Coello, Valentina Barrios, Jaime Navarrete, Adrián Pérez‐Aranda, Lance M. McCracken, Juan V. Luciano   +9 more
wiley   +1 more source

Low cellular pyridoxal 5ʹ-phosphate levels decrease neurotransmitter and glutathione concentrations and increase susceptibility to hydrogen peroxide toxicity in SH-SY5Y cells

Clinical Nutrition Open Science
Summary: Objectives: Pyridoxal 5ʹ-phosphate (PLP) is an active and major form of vitamin B6 (VB6) in the body. PLP is essential as a cofactor for many enzymes involved in amino acid metabolism, and VB6 deficiency is associated with neurological ...
Nana Itoh, Shigenobu Matsumura, Toshio Iwaki, Shigeo Takenaka, Hiroaki Kanouchi   +4 more
doaj   +1 more source

Effects of Exogenous Monosodium Glutamate on GABA Accumulation and Volatile/Nonvolatile Metabolites in Black Highland Barley

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Overview of MSG‐assisted GABA enrichment and associated changes in amino acid, fatty acid, and volatile metabolite profiles in germinated black highland barley. ABSTRACT γ‐Aminobutyric acid (GABA) is a functional amino acid with multiple health benefits; however, the mechanism of its enrichment in black highland barley, particularly through precursor ...
Xiaohang Lu, Nana Ma, Yuan Wang
wiley   +1 more source

The Therapeutic Potential of H2S‐Releasing Platforms in Cardiovascular Applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.
The Therapeutic Potential of H2S‐Releasing Platforms. ABSTRACT Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H2S is a small gas with a short half‐life, making it extremely capable of penetrating ...
Tia N. Shorter, Elizabeth J. Brisbois
wiley   +1 more source

Tumour‐Derived Extracellular Vesicles Containing dsRNA Induce Degradation of Ribosomal Protein mRNA in Platelets

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
ABSTRACT Extracellular vesicles (EVs) mediate intercellular communication within the tumour microenvironment by carrying cargoes from paracrine parent cells. EVs have attracted great research interest for their ability to carry nucleic acids into recipient cells and modulate cellular functions.
Gaoge Sun, Yuhuan Tao, Zihan Liu, Kaixiang Zhang, Shuai Zuo, Shanwen Chen, Shufang Ning, Tianyi Zhang, Pengyuan Wang, Ying Zhang, Zhi John Lu, Hang Hubert Yin   +11 more
wiley   +1 more source

Association between serum pyridoxal 5'-phosphate and kidney stone risk: neutrophil count as a partial mediator

European Journal of Medical Research
Objectives This study analyzed the association between serum pyridoxal 5'-phosphate (PLP) levels and kidney stones (KS) risk. Methods Baseline data of participants were obtained from the 2007–2008 and 2009–2010 cycles of the National Health and Nutrition
Di Chen, Wenju Fan, Qiufeng Zhou, Chengxin Li, Pengnan Hu, GaoMeng Wei   +5 more
doaj   +1 more source

Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broilers

Frontiers in Microbiology
Phellinus linteus polysaccharides (PLP) have been shown to have beneficial effects on gut function and gut microbiota in animals. The intention of this study was to examine the effects of PLP on growth performance, immune function, intestinal barrier ...
Yang Li, Shuai Wang, Xuran Zhu, Nana Gao, Jungang Kang, Tianxiong Wang, Xiaodan Wang   +6 more
doaj   +1 more source

MIF‐MAPMS: Enhancing identification of myelin autoantigenic peptides in multiple sclerosis through multimodal information fusion

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Multiple sclerosis (MS) arises from an autoimmune response in which the immune system erroneously targets myelin autoantigens within the central nervous system, leading to myelin degradation and subsequent neurological dysfunction. Identifying myelin autoantigenic peptides (MAPs) is therefore critical for understanding MS pathogenesis and ...
Watshara Shoombuatong, Nalini Schaduangrat, Pramote Chumnanpuen, Lawankorn Mookdarsanit, Pakpoom Mookdarsanit   +4 more
wiley   +1 more source