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Inference to the Best Explanation Made Incoherent [PDF]
, 2017 Defenders of Inference to the Best Explanation claim that explanatory factors should play an important role in empirical inference. They disagree, however, about how exactly to formulate this role.
Climenhaga, Nevin
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
mSphere, 2018 The pathogenesis of foot-and-mouth disease virus (FMDV) in cattle was investigated through early and late stages of infection by use of an optimized experimental model for controlled contact exposure. Time-limited exposure of cattle to FMDV-infected pigs
Carolina Stenfeldt +8 more
doaj +1 more source
Pathogens, 2020 Foot-and-mouth disease virus (FMDV) infects hosts as a population of closely related viruses referred to as a quasispecies. The behavior of this quasispecies has not been described in detail in natural host species. In this study, virus samples collected
Ian Fish +4 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Proceedings of the 3rd conference on Message understanding - MUC3 '91, 1991 Perhaps the most important facts about our participation in MUC-3 reflect our starting point and goals. In March, 1990, we initiated a pilot study on the feasibility and impact of applying statistical algorithms in natural language processing. The experiments were concluded in March, 1991 and lead us to believe that statistical approaches can ...
Ralph Weischedel +4 more
openaire +1 more source
A computer-assisted existence proof for Emden's equation on an unbounded L-shaped domain
, 2016 We prove existence, non-degeneracy, and exponential decay at infinity of a non-trivial solution to Emden's equation $-\Delta u = | u |^3$ on an unbounded $L$-shaped domain, subject to Dirichlet boundary conditions. Besides the direct value of this result,
Pacella, Filomena +2 more
core +1 more source