Results 181 to 190 of about 1,024,717 (349)

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

Nature Protocols, 2012
Xiaojun Lian, Jianhua Zhang, Samira M. Azarin, Kexian Zhu, Laurie B. Hazeltine, Xiaoping Bao, Cheston Hsiao, T. Kamp, Sean P. Palecek   +8 more
semanticscholar   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

Proceedings of the National Academy of Sciences of the United States of America, 2012

semanticscholar   +1 more source

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro [PDF]

, 2018
Aasen, Abaci, Abaci, Agha, Ahmed, Ahmed, Al-Awar, American Diabetes Association, Amoh, Annette Graham, Ansell, Ansell, Baltzis, Bielefeld, Bilousova, Blaber, Brouwer, Burkart, Burnett, Buta, Buth, Buth, Catherine S. Wright, Ceder, Chan, Chen, Chichagova, Cory, Davidson, Drawnel, Erin M. O’Shaughnessy, Faller, Faniku, Frank, Fujikura, Gerami-Naini, Girard, Gledhill, Golebiewska, Griscelli, Griscelli, Groeber, Guo, Gurdon, Gurdon, Gurdon, Harvey, Hattersley, Hewitt, Hirsch, Hosokawa, Hu, Hu, Hu, Ianitti, Itoh, Itoh, Kandyba, Kim, Kim, Kogut, Kong, Kwak, Laakso, Lapasset, Levitsky, Li, Liu, Loo, Lotte, Maherali, Maione, Mansbridge, Marion, Marro, Martin, Martinez-Santamaria, Martinez-Santamaria, Matsubara, McCormick, Mewes, Mirza, Mori, Morran, Nissan, Nissan, Nunan, Pane, Park, Patni, Patricia E. Martin, Paull, Peloso, Pennarossa, Peppa, Petrova, Pollok, Prigione, Prodinger, Pugliese, Rajaei, Rittie, Roquet, Rostovskaya, Ruiz, Saarimaki-Vire, Sacks, Salvotelli, Schonberger, Schuster, Seah, Shanmugam, Sharpe, Shi, Shtrichman, Siller, Siller, Siller, Singh, Stagi, Steinberg, Steinle, Sugimoto, Sun, Takahashi, Takahashi, Takahashi, Teo, Teo, Toustrup, Tsourdi, Utikal, Van den Broek, Veraitch, Von Joest, Wallet, Wang, Wenzel, Wicks, Wiegland, Wright, Wright, Wright, Yabe, Yang, Yazdanpanah, Young, Yu, Zaccardi, Zhang, Zomer   +150 more
core   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Long QT Syndrome Modelling with Cardiomyocytes Derived from Human-induced Pluripotent Stem Cells

Arrhythmia & Electrophysiology Review, 2019
Luca Sala, Massimiliano Gnecchi, Peter J Schwartz   +2 more
doaj   +1 more source

Generating cerebellar organoids from pluripotent stem cells. [PDF]

Dis Model Mech
Becker EBE, Mayer S, Kutscher LM.
europepmc   +1 more source