Results 181 to 190 of about 173,543 (315)

Induced pluripotent stem cells as platforms for engineering NK cell immunotherapies. [PDF]

Front Cell Dev Biol
Jezierski A, Huang J, Desbiens L, Benabdallah B, McComb S, Beausejour C.   +5 more
europepmc   +1 more source

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

Animal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang, Shicheng Wan, Yanmin Guo, Hongyu Han, Fei Luo, Dongmei Jiang, Xiaorong Yang, Quanhai Pang, Haisheng Yu, Jinlian Hua   +9 more
wiley   +1 more source

Epigenomic regulation of neural crest differentiation in human-induced pluripotent stem cells. [PDF]

iScience
Mukae K, Shindo M, Shi T, Onuki R, Yamashita S, Hattori N, Ushijima T, Ohira M, Kamijo T.   +8 more
europepmc   +1 more source

Neuronal induction of mouse embryonic stem cells following coculture with chick embryonic somites [PDF]

purpose: The aim of the present study was to understand if EBs can promote generation of neurons following co – culture with chick embryo somites. Materials and Methods: The mouse ES cells, line Royan B1, were cultured in hanging drops to induce ...
سقا, محسن, رضوي, شهناز, اسفندياري, ابراهيم, نصر اصفهاني, محمد حسين, کربلایی, خدیجه, بهاروند, حسين   +5 more
core  

Animal research in the UK: Regulation, implementation, welfare and development of new approach methodologies

Animal Models and Experimental Medicine, EarlyView.
Scientific research with animals in the UK is regulated by the Animals (Scientific Procedures) Act 1986 with the National Centre for the Replacement, Refinement and Reduction of Animals in Research providing support for best practice and facilitating development of new approach methodologies.
Ewan St. John Smith, James Bussell, Maggie Gentry, Elliot Lilley, Cathy Merry, Judy MacArthur Clark, William Reynolds   +6 more
wiley   +1 more source

Protocol for the design, conduct, and evaluation of prime editing in human pluripotent stem cells. [PDF]

STAR Protoc
Wu Y, Sidharta M, Zhong A, Persily B, Li M, Zhou T.   +5 more
europepmc   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Protocol to derive human trophoblast stem cells directly from primed pluripotent stem cells. [PDF]

STAR Protoc
Wei Y, Xiao L, Ma L, Wang Z, Huang L, Li H, Pan G, Lye SJ, Shan Y.   +8 more
europepmc   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Patient-derived induced pluripotent stem cells for precision modelling of monogenic beta cell disorders. [PDF]

Front Endocrinol (Lausanne)
Deng L, Krishnamurthy M.
europepmc   +1 more source