Results 191 to 200 of about 5,065,222 (312)

cP1P Maintains Long-Term Pluripotency in Human Pluripotent Stem Cells. [PDF]

Int J Stem Cells
Woo SH, Chae S, Rhie BH, Jo WJ, Park YJ, Choi MJ, Matam V, Ramakrishna S, Hwang D, Kim KS.   +9 more
europepmc   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Induction of human pruriceptors from pluripotent stem cells via transcription factors. [PDF]

Stem Cell Reports
Iriki H, Hu R, Li X, Baljinnyam E, Habich C, Imanishi I, Miller LN, Chegireddy K, Malik LI, Yassky D, Kübler R, Heul AV, Smith KM, Reinhardt P, Goedken ER, Kim BS, Marro SG.   +16 more
europepmc   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

Targeted Differentiation of Regional Ventral Neuroprogenitors and Related Neuronal Subtypes from Human Pluripotent Stem Cells. [PDF]

Stem Cell Reports
Chi L, Fan B, Zhang K, Du Y, Liu Z, Fang Y, Chen Z, Ren X, Xu X, Jiang C, Li S, Ma L, Gao L, Liu L, Zhang X.   +14 more
europepmc   +1 more source

Cardiovascular Organoids With Adjustable Endothelial Composition via SOX17‐Engineered hPSCs

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Organoids are considered a novel modeling platform for studying human biology and advancing health research. With the ability to demonstrate complex 3D structure and multicellular interactions, organoids have advanced studies in all major organs as a reliable model.
Po‐Yu Liang, Gyuhyung Jin, Nathan R. Petrucci, Xiaojun Lance Lian, Xiaoping Bao   +4 more
wiley   +1 more source

Modeling myeloid cell development in health and disease using induced pluripotent stem cells. [PDF]

Front Immunol
Tesakov I, Nasri M, Klimiankou M, Findik B, Loskill P, Skokowa J.   +5 more
europepmc   +1 more source

Microbial Hydrolysates as Amino Acid Source in Cell Culture Media for Cellular Agriculture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The high cost of cultivation media remains one of the barriers to the commercialization of cultivated meat. Current serum‐free media reduce reliance on fetal bovine serum but only achieve modest cost savings. Especially at larger scales (> 20 m3), pharmaceutical‐grade amino acids and recombinant proteins remain major cost drivers.
Jelle C. Hoek, Jean‐Marc Daran, Marieke E. Klijn, Marcel A. Vieira‐Lara   +3 more
wiley   +1 more source

Sodium Butyrate-Assisted Induction of Posterior Pre-Neural Progenitors from Pluripotent Stem Cells. [PDF]

Int J Mol Sci
Oh KT, Kim DH, Hong W, Park K, You H, Lee CK, Oh C, Park GH, You S.   +8 more
europepmc   +1 more source

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source