Results 201 to 210 of about 1,024,717 (349)

Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System

Advanced Electronic Materials, EarlyView.
This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella, Katelyn Neuman, Nolan Burson, Abigail N. Koppes, Ryan A. Koppes   +4 more
wiley   +1 more source

Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells. [PDF]

STAR Protoc
Adami A, Garza R, Dorazehi F, Douse CH, Jakobsson J.   +4 more
europepmc   +1 more source

Chronic Disease Monitoring Using Advanced Compliant Materials for Bioelectronics

Advanced Electronic Materials, EarlyView.
Compliant bioelectronic systems enable continuous monitoring of chronic disease through soft, stretchable materials and tissue‐conformal designs that support stable electrophysiological, mechanical, and biochemical sensing. Integration of diverse sensing modalities with thoughtful material selection, device architectures, and advanced fabrication ...
Han Kim, Mabel Bartlett, Liyang Wang, Karl Bates, Mengdi He, Myungbo Kim, Carmel Majidi, Tzahi Cohen‐Karni   +7 more
wiley   +1 more source

Recapitulating the human segmentation clock with pluripotent stem cells

Nature, 2020
Mitsuhiro Matsuda, Yoshihiro Yamanaka, Maya Uemura, M. Osawa, M. Saito, Ayako Nagahashi, Megumi Nishio, Long Guo, S. Ikegawa, Satoko Sakurai, Shunsuke Kihara, Thomas L. Maurissen, Michiko Nakamura, Tomoko Matsumoto, H. Yoshitomi, M. Ikeya, N. Kawakami, Takuya Yamamoto, K. Woltjen, Miki Ebisuya, J. Toguchida, C. Alev   +21 more
semanticscholar   +1 more source

Dissecting Oct4 enhancer function in pluripotent stem cells and mouse embryogenesis. [PDF]

Stem Cell Reports
Bates LE, Nichols J.
europepmc   +2 more sources

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Retraction: Myogenic differentiation of VCP disease-induced pluripotent stem cells: A novel platform for drug discovery. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Resolution of Refractory Multifocal Atrial Tachycardia in Costello Syndrome Using Trametinib: A Case Supporting MEK Inhibitors as Targeted, Specific Antiarrhythmic

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Arrhythmias affect approximately half of patients with Costello syndrome (CS, OMIM # 218040), with non‐reentrant atrial tachycardia being the most common. This case describes an infant with Costello syndrome carrying the pathogenic HRAS c.34G>A (p.G12S) variant who developed early‐onset, drug‐refractory multifocal atrial tachycardia (MAT ...
Vanina Taliercio, Annabelle Wilcox, Stacey Cole, Josue Flores Daboub, José E. Morales Moreno, Kasey G. Andrews, S. Yukiko Asaki, Thomas A. Pilcher, Martin Tristani‐Firouzi, Mary C. Niu, David Viskochil, Benjamin Hammond   +11 more
wiley   +1 more source

Rapid single-step induction of functional neurons from human pluripotent stem cells.

Neuron, 2013
Yingsha Zhang, ChangHui Pak, Yan Han, H. Ahlenius, Zhenjie Zhang, Soham Chanda, Samuele G. Marro, Christopher Patzke, Claudio Acuna, Jason P. Covy, Wei Xu, Nan Yang, T. Danko, Lu Chen, Marius Wernig, T. Südhof   +15 more
semanticscholar   +1 more source

Zinc dynamics in the pluripotent stem cells during maintenance of pluripotency and pancreatic differentiation. [PDF]

Sci Rep
Shiraki N, Kadokura T, Hashiguchi R, Sim EZ, Kongpracha P, Wiriyasermkul P, Nagamori S, Arakawa A, Kume S.   +8 more
europepmc   +1 more source