Results 231 to 240 of about 980,977 (401)

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells

Nature Genetics, 2020
Yicheng Long, Taeyoung Hwang, A. R. Gooding, Karen J. Goodrich, J. Rinn, T. Cech   +5 more
semanticscholar   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Induced Pluripotent Stem Cells (iPSC) and Their Use in Disease Modeling. [PDF]

Cureus
Dorota A, Maryniak N, Mariankowska A, Milczarek C, Dorota M, Zywiec W, Kozlowski K, Koval I, Czyzewski B, Czyzewska J.   +9 more
europepmc   +1 more source

Directed differentiation of human pluripotent stem cells into epidermal stem and progenitor cells

, 2021
Sonya Ruiz-Torres, Paul F. Lambert, Kathryn A. Wikenheiser‐Brokamp, Susanne I. Wells   +3 more
openalex   +2 more sources

Generation of cerebral organoids from human pluripotent stem cells

Nature Protocols, 2014
Madeline A. Lancaster, J. Knoblich
semanticscholar   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Systemic administration of induced pluripotent stem cell-derived mesenchymal stem cells improves cardiac function through extracellular vesicle-mediated tissue repair in a rat model of ischemic cardiomyopathy

Ryo Kawasumi, Takuji Kawamura, Kizuku Yamashita, Yuji Tominaga, Akima Harada, Emiko Ito, Maki Takeda, Shunbun Kita, Iichiro Shimomura, Shigeru Miyagawa   +9 more
openalex   +1 more source

Generation of lung organoids from human pluripotent stem cells in vitro

Nature Protocols, 2019
Alyssa J Miller, Briana R. Dye, Daysha Ferrer-Torres, David R. Hill, Arend W. Overeem, L. Shea, J. Spence   +6 more
semanticscholar   +1 more source

PEDOT:PSS—A Key Material for Bioelectronics

Advanced Science, EarlyView.
PEDOT:PSS ‐ Poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate ‐ is typically processed from water dispersions to form multifunctional and multidimensional constructs with tunable electronic and ionic conductivity. Throught processing engineering, PEDOT:PSS is intergrated in bioelectronic devices that operate efficiently in physiological conditions
Alan Eduardo Ávila Ramírez, David Pieter van der Laan, Mustafeez Bashir Shah, Liwen Wang, Erica Zeglio, Achilleas Savva   +5 more
wiley   +1 more source