Results 51 to 60 of about 998,880 (306)
Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]
, 2018 Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat +3 more
core +1 more source
Generation of a human embryonic stem cell line (WAe009-A-78) carrying homozygous TBX18 knockout
Stem Cell Research, 2022 T-Box Transcription Factor 18 is a member of the T-box family, encoding TBX18 protein. As a transcriptional repressor, it related to developmental processes of a majority of tissues and organs and plays crucial part in the embryonic development of ...
Qi Xu +5 more
doaj
Metaboloepigenetic Regulation of Pluripotent Stem Cells [PDF]
Stem Cells International, 2015 The differentiation of pluripotent stem cells is associated with extensive changes in metabolism, as well as widespread remodeling of the epigenetic landscape. Epigenetic regulation is essential for the modulation of differentiation, being responsible for cell type specific gene expression patterns through the modification of DNA and histones, thereby ...
Alexandra J. Harvey +2 more
openaire +4 more sources
Stem Cell Research, 2023 The voltage-gated potassium channel KvLQT1 encoded by KCNQ1 plays an important role in the repolarization of myocardial action potentials. KCNQ1 mutations can cause Long QT syndrome type 1 (LQT1), which is considered to be the most common causative gene ...
Hongyue Wang, Tianwei Guo, Feng Lan
doaj
Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. [PDF]
PLoS ONE, 2017 Oligodendrocytes myelinate axons and form myelin sheaths in the central nervous system. The development of therapies for demyelinating diseases, including multiple sclerosis and leukodystrophies, is a challenge because the pathogenic mechanisms of ...
Tomoko Yamashita +12 more
doaj +1 more source
The plant stem-cell niche and pluripotency: 15 years of an epigenetic perspective
Frontiers in Plant Science, 2022 Pluripotent stem-cells are slowly dividing cells giving rise to daughter cells that can either differentiate to new tissues and organs, or remain stem-cells.
Ralf Müller-Xing, Qian Xing
doaj +1 more source
Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche. [PDF]
, 2017 A major challenge in stem cell differentiation is the availability of bioassays to prove cell types generated in vitro are equivalent to cells in vivo. In the mouse, differentiation of primordial germ cell-like cells (PGCLCs) from pluripotent cells was ...
Chen, Di +13 more
core +2 more sources
Stem Cell Research & Therapy, 2017 Background Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease modeling.
Elvira Parrotta +13 more
doaj +1 more source
Pluripotent Adult Stem Cells: A Potential Revolution in Regenerative Medicine and Tissue Engineering [PDF]
, 2013 Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential.
Cheung, Herman S. +4 more
core +2 more sources
A stochastic and dynamical view of pluripotency in mouse embryonic stem cells [PDF]
, 2017 Pluripotent embryonic stem cells are of paramount importance for biomedical research thanks to their innate ability for self-renewal and differentiation into all major cell lines. The fateful decision to exit or remain in the pluripotent state is regulated by complex genetic regulatory network.
arxiv +1 more source