Results 111 to 120 of about 16,822 (237)

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Pluronic F127 and D-α-Tocopheryl Polyethylene Glycol Succinate (TPGS) Mixed Micelles for Targeting Drug Delivery across The Blood Brain Barrier

Scientific Reports, 2017
A novel polymeric mixed micelle composed of Pluronic F127 and D-α-tocopheryl polyethylene glycol succinate (TPGS) was developed to improve the delivery of fluorescent dyes and protein across the blood brain barrier (BBB).
Xin Meng, Jiansheng Liu, Xiangrong Yu, Jiajia Li, Xiaotong Lu, Teng Shen   +5 more
doaj   +1 more source

Pluronic® block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances [PDF]

, 2014
YesThis mini-review highlights the latest advances in the chemistry and biology of Pluronic® triblock copolymers. We focus on their applications in medicine, as drug delivery carriers, biological response modifiers, and pharmaceutical ingredients ...
Acharya, Alakhova, Alakhova, Alexandridis, Alivisatos, Anaïs Pitto-Barry, Andrews, Bangham, Bareford, Barry, Barry, Batrakova, Batrakova, Batrakova, Batrakova, Batrakova, Batrakova, Batrakova, Bissery, Boyd, Boyd, Brown, Cervin, Chen, Chen, Chong, Collet, Drummond, Engstrom, Fan, Gariepy, Gelderblom, Gref, Gucu, Höfig, Jiang, Jokerst, Kabanov, Kabanov, Kamaly, Kirtane, Konno, Kurahashi, Lee, Liu, Malmsten, Minko, Moghaddam, Neumann, Nicolas P. E. Barry, Oh, Schmolka, Steinbach, Uyama, Valle, Venne, Wang, Watson, Weiss, Wu, Xing, Yaghmur, Yuk, Zhou   +63 more
core   +1 more source

Guidelines for the preparation of hydrogels with protective function

Food Biomacromolecules, EarlyView.
Abstract As three dimensional network structure functional materials, protective hydrogels, with their excellent biocompatibility, high water content, and the ability to provide physical barriers and regulate the environment for active substances/cells, have shown broad prospects in fields such as drug delivery, tissue engineering, and food ...
Xiao‐Lin Yu, Hao‐Yu Xue, Nuo Wang, Zi‐Jun Xue, Jin‐Long Tian   +4 more
wiley   +1 more source

Olmesartan medoxomil-loaded mixed micelles: Preparation, characterization and in-vitro evaluation

Future Journal of Pharmaceutical Sciences, 2017
Olmesartan medoxomil (OLM) is highly lipophilic in nature (log p = 4.31) which attributes to its low aqueous solubility contributing to its low bioavailability 25.6%.
Mohamed A. El-Gendy, Mona I.A. El-Assal, Mina Ibrahim Tadros, Omaima N. El-Gazayerly   +3 more
doaj   +1 more source

Freeze‐resistant, conductive semi‐interpenetrating network hydrogels enable oxidative stress regulation and enhanced wound healing

Interdisciplinary Medicine, EarlyView.
A multifunctional SFMA9/PF1 semi‐interpenetrating hydrogel with excellent conductivity, antioxidant activity, and freeze resistance effectively regulates the wound microenvironment, reduces oxidative stress and inflammation, promotes angiogenesis, and accelerates full‐thickness skin regeneration.
Xiaomin Sun, Yanqin Yu, Xinyuan He, Kaiyi Tang, Lijing Teng, Tianbao Qian, Zhu Zeng, Zuquan Hu   +7 more
wiley   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Effect of Pluronic F127 Concentration on Gelling Temperature and other Parameters of Lomustine Mucoadhesive In-Situ Gel

Iraqi Journal of Pharmaceutical Sciences
Pluronic F127 is one of the widely used thermoreversible gelling agent, and used in sol-to-gel transformation. It has been used to localize drug delivery such as nose-to-brain delivery which allows the direct targeting of drug molecules bypassing the ...
Maryam H. Alaayedi, Nidhal Khazaal Maraie   +1 more
doaj   +1 more source

Extended Fused Carbazole‐BODIPY, High Brightness NIR Organic Dyes

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Highly fused boron‐dipyrromethene (BODIPY) with a strong donor group has been synthesized, and their photophysical behaviors fully characterized. They exhibit outstanding brightness for fluorophores emitting in the NIR region. Water‐soluble nanoparticles filled with one of these dyes demonstrate high efficiency as the NIR II visualization agent ...
Fabien Ceugniet, Valentin Ott, Pascal Retailleau, Yann Bretonniere, Olivier Maury, Manon H. E. Bousquet, Lucie Sancey, Nicolas Leclerc, Denis Jacquemin, Gilles Ulrich   +9 more
wiley   +2 more sources

Ginsenoside Rg3 micelles mitigate doxorubicin-induced cardiotoxicity and enhance its anticancer efficacy

Drug Delivery, 2017
Doxorubicin (DOX) is one of the most effective chemotherapy agents used in the treatment of hematological and solid tumors, however, it causes dose-related cardiotoxicity that may lead to heart failure in patients.
Lan Li, Jingyu Ni, Min Li, Jingrui Chen, Lifeng Han, Yan Zhu, Deling Kong, Jingyuan Mao, Yi Wang, Boli Zhang, Meifeng Zhu, Xiumei Gao, Guanwei Fan   +12 more
doaj   +1 more source