Results 41 to 50 of about 40,105 (240)

Myeloid-Specific Pyruvate-Kinase-Type-M2-Deficient Mice Are Resistant to Acute Lung Injury

Biomedicines, 2022
Infiltration of polymorphonuclear neutrophils (PMNs) plays a central role in acute lung injury (ALI). The mechanisms governing PMN inflammatory responses, however, remain incompletely understood.
Xinlei Sun, Fujie Shi, Weiran Wang, Yunfei Wu, Shuang Qu, Jing Li, Hongwei Liang, Ke Zen   +7 more
doaj   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis

Journal of Translational Medicine, 2019
Background Polymorphonuclear (PMN) elastase plays an important role in a variety of inflammatory disorders. Our aim was to analyse PMN elastase in idiopathic inflammatory myopathies (IIMs) and its association with disease activity.
Siyu Wu, Wanchan Peng, Yunli Zhang, Jingjing Guo, Jinfang Fu, Wei Wang   +5 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells Promote the Progression of Primary Membranous Nephropathy by Enhancing Th17 Response

Frontiers in Immunology, 2020
Several studies have confirmed that the myeloid-derived suppressor cells (MDSCs) are closely associated with autoimmune diseases, but their exact role in these processes remains largely unclear.
Huimin Li, Huimin Li, Huimin Li, Hao Wu, Qiaoyan Guo, Hongyu Yu, Ying Xu, Jinyu Yu, Zhongkun Wang, Huanfa Yi, Huanfa Yi   +10 more
doaj   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Bacterial Killing Activity of Polymorphonuclear Myeloid-Derived Suppressor Cells Isolated From Tumor-Bearing Dogs

Frontiers in Immunology, 2019
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are implicated in the progression and outcome of a variety of pathological states, from cancer to infection.
Sabina I. Hlavaty, Yu-Mei Chang, Rachel P. Orth, Mark Goulian, Paul J. Planet, Paul J. Planet, Douglas H. Thamm, Jennifer A. Punt, Oliver A. Garden   +8 more
doaj   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. [PDF]

PLoS ONE, 2011
Polymorphonuclear neutrophils (PMN) mediate early immunity to infection but can also cause host damage if their effector functions are not controlled.
Mike Hasenberg, Anja Köhler, Susanne Bonifatius, Katrin Borucki, Monika Riek-Burchardt, Julia Achilles, Linda Männ, Kathleen Baumgart, Burkhart Schraven, Matthias Gunzer   +9 more
doaj   +1 more source

A Bio‐Inspired Visual Sensor With UV‐to‐NIR Fusion for Enhanced Recognition in Autonomous Driving Systems

Advanced Science, EarlyView.
Inspired by the sophisticated multilayer retinal architecture found in Pacific salmon eyes, a novel van der Waals heterojunction sensor based on NbNiTe5/BP is designed. Upon illumination at distinct wavelengths of 365 and 820 nm, the device exhibits distinctive bipolar photocurrent responses with opposite polarities. This unique optoelectronic behavior
Tianle Zeng, Zishen Zhao, Keqin Tang, Yawen Luo, Junxin Yan, Kun Ye, Jinlu Liu, Zhuo Dong, Zhipeng Yu, Weiming Lv, Ruicheng Li, Yenasheng Li, Lixuan Liu, Tianyu Xue, Chun Zhao, Yan Zhou, Kai Zhang, Zhongming Zeng, Zhongyuan Liu   +18 more
wiley   +1 more source

Differential inhibition of polymorphonuclear leukocyte recruitment in vivo by dextran sulphate and fucoidan

Mediators of Inflammation, 1996
The selectin-mediated rolling of leukocytes along the endothelial cells is a prerequisite step followed by firm adhesion and extravasation into the inflamed tissue. This initial contact can be suppressed by sulphated polysaccharides.
N. Van Osselaer, M. Rampart, A. G. Herman   +2 more
doaj   +1 more source