Results 61 to 70 of about 40,105 (240)

Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation‐Associated Paraptosis‐Like Cell Death in Colorectal Cancer

Advanced Science, EarlyView.
This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song, Sikei Kam, Jingyi Liu, Rui Lv, Xucheng Huo, Zhanghan Chen, Yuelun Dong, Shilun Cai, Bing Li, Ruobing Ren, Yunshi Zhong, Mingyan Cai   +11 more
wiley   +1 more source

Podocyte Pathogenic Bone Morphogenetic Protein‐2 Pathway and Immune Cell Behaviors in Primary Membranous Nephropathy

Advanced Science
Primary membranous nephropathy (PMN) is one of the leading causes of end‐stage renal disease, and the most frequent cause of massive proteinuria in nondiabetic adults, resulting in fatal complications.
Anxiang Cai, Yiwei Meng, Hang Zhou, Hong Cai, Xinghua Shao, Qin Wang, Yao Xu, Yin Zhou, Wenyan Zhou, Luonan Chen, Shan Mou   +10 more
doaj   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Sialylation regulates neutrophil transepithelial migration, CD11b/CD18 activation, and intestinal mucosal inflammatory function

JCI Insight, 2023
Polymorphonuclear neutrophils (PMNs) play a critical role in clearing invading microbes and promoting tissue repair following infection/injury. However, dysregulated PMN trafficking and associated tissue damage is pathognomonic of numerous inflammatory ...
Veronica Azcutia, Matthias Kelm, Dylan Fink, Richard D. Cummings, Asma Nusrat, Charles A. Parkos, Jennifer C. Brazil   +6 more
doaj   +1 more source

Magnetoelectric Multiferroics for the Next‐Generation Ultralow‐Power Electronics

Advanced Science, EarlyView.
Magnetoelectric coupling provides a unifying route from electric‐field control of magnetic order to non‐volatile MeRAM, MESO logic, and emerging antiferromagnetic and magnonic devices. By connecting switching physics with device benchmarks, material platforms, and integration strategies, distinctive technological opportunities are identified alongside ...
Yang Liu, Yunlong Sun, Hao Luo, Duoduo Zhao, Yuhan Zeng, Xuzihan Zhang, Zhewei Liu, Hao Peng, Zhijing Zhang, Jack Yang, Ji Zhang, Danyang Wang, Junjie Shi, Sean Li   +13 more
wiley   +1 more source

Molecularly Engineered Nitrate Double Perovskites with Elevated Ferroelectric Phase Transition Temperature and Large Piezoelectric Response

Advanced Science, EarlyView.
This study reports molecularly engineered nitrate double perovskites based on systematic BI‐site cation substitution. This molecular engineering modulates local BI···NO3 interactions, nitrate connectivity, and collective physical responses, accompanied by structural conversion from mixed corner‐/face‐sharing structures to three‐dimensional corner ...
Le Ye, Guang‐Yuan Hu, Yarou Duan, Yutong Lin, Ding‐Chong Han, Zi‐Luo Fang, Zhe Dong, Wei‐Xiong Zhang, Liang‐Han Shen, Na Wang, Le‐Ping Miao, Heng‐Yun Ye, Lingling Mao   +12 more
wiley   +1 more source

Research progress on the pathogenesis of primary membranous nephropathy

Guangxi Yike Daxue xuebao
This article reviews the pathogenesis of primary membranous nephropathy (PMN) in recent years, encompassing the latest findings of genetic, antigenic, environmental factors, and intestinal flora, etc., so as to provide a reference for further ...
LIU Jianing, ZHU Junjie, LIU Yun, CEN Tao, ZHANG Li'e, NONG Qingqing   +5 more
doaj   +1 more source