Results 81 to 90 of about 40,105 (240)

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber, Mario R. Angeli, Hashem Mohammadian, Hannah Labinsky, Maria Gabriella Raimondo, Richard Demmler, Yuko Ariza, Thomas Wohlfahrt, Markus Luber, Yi‐Nan Li, Jörg H.W. Distler, Tobias Bäuerle, Georg Schett, Simon Rauber, Andreas Ramming, Alina M. Ramming   +15 more
wiley   +1 more source

CCL26–CX3CR1 Axis Mediates a Feedback Loop between Cancer Cell and PMN-MDSCs to Promote CD8+ T Cell Exhaustion during Stomach Carcinogenesis

Research
The development of an immunosuppressive microenvironment is a critical factor in stomach carcinogenesis. Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) serve a pivotal function in mediating immune suppression.
Xiaotao Jiang, Hui Wu, Ning Yan, Anzhou Wu, Xianzhe Wang, Yi Wen, Jinqi An, Jingming Chen, Jiaxing Yan, Changlong Wang, Yushan Zou, Yuancheng Huang, Wei Wang, Peiwu Li, Kunhai Zhuang, Yufeng Liu, Fengbin Liu   +16 more
doaj   +1 more source

Neutrino Oscillation in a Minimal Length Spacetime

Astronomische Nachrichten, EarlyView.
ABSTRACT We investigate how neutrino oscillations are modified in a non‐commutative spacetime characterized by a minimal length scale, described by the Quesne–Tkachuk algebra. By incorporating the algebra's deformation parameter β$$ \beta $$ into the effective neutrino mass, we derive the two‐flavor oscillation probability in this non‐commutative ...
Luísa Nadal‐Camargo, Thiago Oliveira Ferreira, Dimiter Hadjimichef, César A. Z. Vasconcellos   +3 more
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Radiologic, Histologic and Scanning Electron Microscopic Characterization of the Peritoneal Reflection in Crohn's Disease

Clinical Anatomy, EarlyView.
ABSTRACT The peritoneal reflection bridges visceral and parietal peritoneum and lacks adjoining or underlying organs. As such it provides an opportunity to perform a focussed examination of the peritoneum in Crohn's disease. The aim of this study was to exploit this anatomical property and conduct a multilayered, focussed examination of the peritoneal ...
L. Walsh, D. Walsh, C. P. Dunne, P. Dockery, J. C. Coffey   +4 more
wiley   +1 more source

A Trans‐1,2‐Diphenyl‐Substituted EDTA Platform for High‐Relaxivity Mn(II) MRI Probes

Chemistry – A European Journal, EarlyView.
Symmetric diphenyl substitution of the EDTA backbone enhances the rigidity of the Mn(II) complex and enables strong multisite interactions, providing a versatile platform for further functionalisation and conjugation towards high‐performance Mn(II)‐based MRI contrast agents.
Federico Forgione, Alessandro Nucera, Marco Ricci, Attila Benyei, Mariangela Boccalon, Zsolt Baranyai, Giovanni B. Giovenzana, Mauro Botta   +7 more
wiley   +1 more source

Rekonstruksi Pertanggungjawaban Penggunaan Penyertaan Modal Negara kepada Perseroan sebagai Manifestasi Kebangkitan Perekonomian Berdasarkan Prinsip Good Corporate Governance

Unes Journal of Swara Justisia
Penelitian ini menganalisis kelemahan pengaturan Penyertaan Modal Negara (PMN) pada Badan Usaha Milik Negara (BUMN) Persero yang berimplikasi terhadap belum optimalnya penerapan prinsip Good Corporate Governance, khususnya pada aspek akuntabilitas dan ...
Muhammad Luthfi Ghifari, Sukarmi, Shinta Hadiyantina, Djumikasih   +3 more
doaj   +1 more source

Citizen Science Gamers Enable Automated Flow Cytometry Gating Through Machine Learning

Cytometry Part A, EarlyView.
ABSTRACT Machine learning can greatly accelerate biomedical research but is fundamentally constrained by the scarcity of high‐quality labeled data. We introduce a scalable data‐generation framework based on citizen science and apply it to automated flow cytometry gating, a foundational but subjective step in immunology that limits reproducibility ...
Sebastiano Montante, Daniel Yokosawa, Leon Li, Alexander Butyaev, Mehrnoush Malek, Razzi Movassaghi, Quentin Michalchuk, Chieh‐Ting Jimmy Hsu, David Shmil, Albina Rahim, Andrea Cossarizza, Julia Boira Esteban, Kornél Erhart, Bergur Finnbogason, George Kelion, Hjalti Leifsson, Josh Rivers, David Ecker, Attila Szantner, Jérôme Waldispühl, Ryan R. Brinkman   +20 more
wiley   +1 more source

Evaluation of retinal microcirculation by optical coherence tomography angiography in patients with primary membranous nephropathy

Photodiagnosis and Photodynamic Therapy
Background: Primary membranous nephropathy (PMN) patients may experience retinal microvascular changes. However, current diagnostic methods for PMN are not accurate in analyzing these modifications.
Guihong Wu, Mengxia Cao, Tianyu Yao, Wei Yang, Zhiru Zhang, Chen Qiu, Xueqin Zhang, Shuhan Zeng, Rui Wang, Santao Ou, Yue He   +10 more
doaj   +1 more source