Results 71 to 80 of about 40,105 (240)

Polymorphonuclear MDSCs are enriched in the stroma and expanded in metastases of prostate cancer

The Journal of Pathology: Clinical Research, 2020
Myeloid‐derived suppressor cells with polymorphonuclear morphology (PMN‐MDSCs) contribute to the progression and immune evasion of prostate cancer. However, the spatial distribution of tumor‐infiltrating PMN‐MDSCs in primary and metastatic prostate ...
Jiling Wen, Gang Huang, Sheng Liu, Jun Wan, Xuechun Wang, Yini Zhu, William Kaliney, Chao Zhang, Liang Cheng, Xiaofei Wen, Xin Lu   +10 more
doaj   +1 more source

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source

An Intelligent Piezoelectric System Integrating Self‐Sensing and Autonomous Operation for Adaptive Vibration Control

Advanced Intelligent Systems, EarlyView.
An intelligent piezoelectric vibration control system integrating self‐sensing, autonomous operation, and adaptive bias‐flip synchronized switching damping (SSD) is developed. The system detects vibration extrema, executes synchronized switching control, and autonomously establishes the bias voltage without external sensing instruments, achieving ...
Hao Tang, Weiqun Liu, Guobiao Hu
wiley   +1 more source

Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota

Renal Failure
Background Research has showcased a correlation between disruptions in gut microbiota and primary membranous nephropathy (pMN), giving rise to the concept of the ‘gut-kidney axis’.
Jianwei Wu, Jing Zhang, Gang Huang, Yinglian Zhong, Yi Yang, Peng Deng   +5 more
doaj   +1 more source

Exploring immunological alterations of B cells in peripheral immunity via single-cell RNA sequencing: insights into primary membranous nephropathy

Frontiers in Immunology
BackgroundPrimary Membranous Nephropathy (PMN) is characterized by dysregulated immune responses, with B cells playing critical roles in disease pathogenesis.
Fang Lu, Si Chen, Honglei Guo, Qing Li, Lin Wu, Ying Pan, Yangfan Wu, Hua Shu, Simeng Liu, Bo Zhang, Huijuan Mao, Changying Xing, Hongwei Liang, Suyan Duan, Yanggang Yuan   +14 more
doaj   +1 more source

Comparative Analysis of Poly(Ethylene Glycol) (PEG) and Poly(2‐Ethyl‐2‐Oxazoline) (PEtOx) for Organic Solvent‐Free Lipid Nanoparticle Formulations

Angewandte Chemie International Edition, EarlyView.
Organic solvent‐free lipid nanoparticles featuring PEtOx‐based stealth lipids enable efficient mRNA and CRISPR‐Cas9 delivery while exhibiting markedly improved biocompatibility compared with PEG‐based analogues. Their successful ex vivo and in vivo performance, combined with data‐driven formulation optimization, establishes a versatile platform that ...
Michael Streiber, Caroline T. Holick, Lucas Gath, Ekaterina Tsarenko, Vivien Bachmann, Stavroula Litsiou, Lukas Harder, Laura J. Rosenberger, Aleksandar Rusevski, Julian Kimmig, Stephan Culemann, Christian Franke, Claudia Waskow, Stephanie Hoeppener, Stephanie Schubert, Matthias Bros, Oliver Werz, Ivo Nischang, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +21 more
wiley   +1 more source

Early evolution of the gular musculature and its innervation in ray‐finned fishes

The Anatomical Record, EarlyView.
Abstract Gular muscles are an important but often overlooked component of cranial anatomy in bony fishes. They are located on the ventral surface of the head and are derived from the mandibular and hyoid arches. We present a comprehensive review of the gular musculature and its innervation across early diverging actinopterygian lineages. By integrating
Aléssio Datovo, Paulo Presti, George Vita, Murilo N. L. Pastana, Luiz A. W. Peixoto   +4 more
wiley   +1 more source

Quantitative muscle architecture in large carnivorous marsupials (Marsupialia: Dasyuridae) and links to substrate use and prey processing

The Anatomical Record, EarlyView.
Abstract The Dasyurid species Sarcophilus harrisii, Dasyurus maculatus, and Dasyurus viverrinus, occupying diverse ecological niches and forming a guild structure in Tasmania, provide a basis for examining the roles of various forelimb muscle groups in prey capture and locomotion.
Riya G. Bidaye, Samuel H. Frenkel, David P. Hocking, Alistair R. Evans, Justin W. Adams   +4 more
wiley   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Bovine PMN responses to extracellular vesicles released by Besnoitia besnoiti tachyzoites and B. besnoiti-infected host cells

Frontiers in Immunology
Bovine besnoitiosis is a re-emerging cattle disease caused by the apicomplexan parasite Besnoitia besnoiti, which severely affects individual animal welfare and profitability in cattle industry. We recently showed that B.
Gabriel Espinosa, Constanza Salinas-Varas, Lisbeth Rojas-Barón, Christian Preußer, Elke Pogge von Strandmann, Ulrich Gärtner, Iván Conejeros, Carlos Hermosilla, Anja Taubert   +8 more
doaj   +1 more source