Results 51 to 60 of about 49,900 (290)

Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet’s disease

Nature Communications
Behçet’s disease (BD) is a life-threatening systemic vasculitis characterized by polymorphonuclear neutrophils (PMN) and macrophage activation. However, the interaction of PMN and macrophages remains elusive.
Xin Yu, Menghao Zhang, Na Kang, Chaoran Li, Zhimian Wang, Yiyuan Ao, Lu Li, Xiao’ou Wang, Yeling Liu, Lidan Zhao, Li Wang, Min Shen, Jinjing Liu, Yan Zhao, Fengchun Zhang, Hua Chen, Wenjie Zheng   +16 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells Promote the Progression of Primary Membranous Nephropathy by Enhancing Th17 Response

Frontiers in Immunology, 2020
Several studies have confirmed that the myeloid-derived suppressor cells (MDSCs) are closely associated with autoimmune diseases, but their exact role in these processes remains largely unclear.
Huimin Li, Huimin Li, Huimin Li, Hao Wu, Qiaoyan Guo, Hongyu Yu, Ying Xu, Jinyu Yu, Zhongkun Wang, Huanfa Yi, Huanfa Yi   +10 more
doaj   +1 more source

Neutrophil-Specific Knockdown of β2 Integrins Impairs Antifungal Effector Functions and Aggravates the Course of Invasive Pulmonal Aspergillosis

Frontiers in Immunology, 2022
β2-integrins are heterodimeric surface receptors that are expressed specifically by leukocytes and consist of a variable α (CD11a-d) and a common β-subunit (CD18).
Maximilian Haist, Frederic Ries, Matthias Gunzer, Matthias Gunzer, Monika Bednarczyk, Ekkehard Siegel, Michael Kuske, Stephan Grabbe, Markus Radsak, Matthias Bros, Daniel Teschner, Daniel Teschner   +11 more
doaj   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. [PDF]

PLoS ONE, 2011
Polymorphonuclear neutrophils (PMN) mediate early immunity to infection but can also cause host damage if their effector functions are not controlled.
Mike Hasenberg, Anja Köhler, Susanne Bonifatius, Katrin Borucki, Monika Riek-Burchardt, Julia Achilles, Linda Männ, Kathleen Baumgart, Burkhart Schraven, Matthias Gunzer   +9 more
doaj   +1 more source

Interferon Regulatory Factor 4 Regulates the Development of Polymorphonuclear Myeloid-Derived Suppressor Cells Through the Transcription of c-Myc in Cancer

Frontiers in Immunology, 2021
The accumulation of myeloid-derived suppressor cells (MDSCs) is one of the major obstacles to achieve an appropriate anti-tumor immune response and successful tumor immunotherapy.
Quan Yang, Quan Yang, Hongyan Xie, Xing Li, Yuanfa Feng, Shihao Xie, Jiale Qu, Anqi Xie, Yiqiang Zhu, Lu Zhou, Jinxue Yang, Xiaohao Hu, Haixia Wei, Huaina Qiu, Wenjuan Qin, Jun Huang, Jun Huang   +16 more
doaj   +1 more source

Orbital Magnetic Moment Controlled Converse Magnetoelectric Effect in bcc‐Co3Mn/Fe/V/PMN‐PT Multiferroic Heterostructures

Advanced Science, EarlyView.
Based on orbital magnetic moment control, a material design strategy is proposed for a giant converse magnetoelectric effect in multiferroic heterostructures. This study will pioneer a promising route toward low‐power spintronic devices with an electric field.
Takamasa Usami, Yuichi Murakami, Ryota Watarai, Yu Shiratsuchi, Yoshihiro Gohda, Kohei Hamaya   +5 more
wiley   +1 more source

Fungicidal capacity of PMN.

, 2015
A—Colony forming units (CFU) of Pb at 7 and 12 days evaluation for non-irradiated and irradiated PMN. p = 0.0002 (*) between non-irradiated and irradiated PMN after 12 days of fungal growth; p = 0.0118 (*) between the irradiated groups at 7 and 12 days ...
Giulia M. A. C. Bani (692173), Ana Carolina S. C. Mendes (692172), Maísa R. P. L. Brigagão (692174), Liana M. Verinaud (692178), Michael R. Hamblin (82790), Felipe F. Sperandio (692179), Zoilo P. de Camargo (513545), Gérsika B. Santos (692175), Luiz Cosme C. Malaquias (692176), Eva Burger (692171), Jorge Kleber Chavasco (692177)   +10 more
core   +1 more source

Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis

Journal of Translational Medicine, 2019
Background Polymorphonuclear (PMN) elastase plays an important role in a variety of inflammatory disorders. Our aim was to analyse PMN elastase in idiopathic inflammatory myopathies (IIMs) and its association with disease activity.
Siyu Wu, Wanchan Peng, Yunli Zhang, Jingjing Guo, Jinfang Fu, Wei Wang   +5 more
doaj   +1 more source

Bacterial Killing Activity of Polymorphonuclear Myeloid-Derived Suppressor Cells Isolated From Tumor-Bearing Dogs

Frontiers in Immunology, 2019
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are implicated in the progression and outcome of a variety of pathological states, from cancer to infection.
Sabina I. Hlavaty, Yu-Mei Chang, Rachel P. Orth, Mark Goulian, Paul J. Planet, Paul J. Planet, Douglas H. Thamm, Jennifer A. Punt, Oliver A. Garden   +8 more
doaj   +1 more source