Results 51 to 60 of about 40,105 (240)

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Single-cell transcriptomic analysis reveals heterogeneous features of myeloid-derived suppressor cells in newborns

Frontiers in Immunology
The transitory emergence of myeloid-derived suppressor cells (MDSCs) in infants is important for the homeostasis of the immune system in early life.
Meng Yao, Yingjiao Cao, Juan He, Rui Dong, Gaoyu Liu, Yingying Chen, Jun Wang, Jie Zhou   +7 more
doaj   +1 more source

Increased neutrophil apoptosis in chronically SIV-infected macaques

Retrovirology, 2009
Polymorphonuclear neutrophils (PMN) from chronically HIV-infected individuals have been reported to be more prone to die. However, although non-human primates models have been extensively used for improving our knowledge on T cell immunity, the impact of
Gougerot-Pocidalo Marie-Anne, Hurtrel Bruno, François Stéphanie, Monceaux Valérie, Elbim Carole, Estaquier Jérome   +5 more
doaj   +1 more source

Large Electrostrain and High Optical Transmittance via Oxygen Octahedron Rotation Disordering in KNN Ceramics

Advanced Science, EarlyView.
Chemical disorder engineering reconfigures BO6 oxygen‐octahedron rotations in lead‐free K0.5Na0.5NbO3 ceramics from local ordering into a random distribution, dissolving the longstanding trade‐off between optical transparency and electromechanical strain.
Xia Luo, Jian Wang, Yu Tan, Jiyang Xie, Thamil Selvi Velayutham, Wanbiao Hu   +5 more
wiley   +1 more source

Freestanding PZT Films for Integrated Wearable Sensing and Intelligent Acoustic Recognition

Advanced Science, EarlyView.
A freestanding epitaxial PZT/LaNiO3/Pt heterostructure is achieved via water‐assisted delamination from mica, effectively eliminating substrate‐induced clamping and releasing intrinsic ferroelectricity. The released film exhibits substantially enhanced remanent polarization and piezoelectric response, delivering excellent mechanical flexibility and ...
Hailong Pan, Zhichao Xu, Rongxiao Liu, Jianmei Pei, Changhong Yang, Shifeng Huang, Michael Wübbenhorst   +6 more
wiley   +1 more source

Establishing a differential diagnosis model between primary membranous nephropathy and non-primary membranous nephropathy by machine learning algorithms

Renal Failure
Context Four algorithms with relatively balanced complexity and accuracy in deep learning classification algorithm were selected for differential diagnosis of primary membranous nephropathy (PMN).Objective This study explored the most suitable ...
Shangmei Cao, Shaozhe Yang, Bolin Chen, Xixia Chen, Xiuhong Fu, Shuifu Tang   +5 more
doaj   +1 more source

Uniaxial Strain‐Driven Ferroelastic Domain Tuning in LaAlO3${\rm LaAlO}_3$

Advanced Science, EarlyView.
The present work demonstrates based on AFM, μ$\umu$‐Raman spectroscopy, XRD, and first‐principles, that uniaxial strain provides a handle for tuning the ferroelastic domain populations in lanthanum aluminate, driving a continuous and controlled phase transition from a four‐variant rhombohedral crystal system to a two‐variant orthorhombic crystal system
Matthias Roeper, Robin Buschbeck, Jakob Wetzel, Tobias Ritschel, Anna‐Lena Hofmann, Vladyslav Kovtunovych, Mike N. Pionteck, Javier Taboada‐Gutiérrez, Alexey B. Kuzmenko, Martina Basini, Vivek Unikandanunni, Iuliia Kiseleva, Jochen Geck, Susanne C. Kehr, Maximilian Lederer, Simone Sanna, Lukas M. Eng, Samuel D. Seddon   +17 more
wiley   +1 more source

Engineering Polar Nanoregions in COFs via Controlled Symmetry Breaking Toward Piezocatalysis

Angewandte Chemie, EarlyView.
Polar nanoregions (PNRs) are engineered within covalent organic frameworks via asymmetric grafting of highly polar polyfluoroalkyl chains, which enables controlled symmetry breaking. These randomly oriented artificial PNRs dynamically respond to mechanical stimuli and impart relaxation behavior to the COFs (TFB‐TAPT‐FA).
Ge Yan, Yixuan Wang, Xiaodong Sun, Liberty L. Mguni, Shuai Zhang, Shiyuan Liu, Xue Zhou, Lingfeng Zhu, Yali Yao, Hongwei Huang, Liqun Ye, Xinyi Yang, Bo Zou, Tianyi Ma   +13 more
wiley   +2 more sources

Formyl Met-Leu-Phe-Stimulated FPR1 Phosphorylation in Plate-Adherent Human Neutrophils: Enhanced Proteolysis but Lack of Inhibition by Platelet-Activating Factor

Journal of Immunology Research, 2018
N-formyl-Met-Leu-Phe (fMLF) is a model PAMP/DAMP driving human PMN to sites of injury/infection utilizing the GPCR, FPR1. We examined a microtiter plate format for measurement of FPR1 phosphorylation in adherent PMN at high densities and found that a new
Algirdas J. Jesaitis, Jeannie Gripentrog, Jovanka M. Voyich   +2 more
doaj   +1 more source