Results 121 to 130 of about 21,552 (215)

Immunohistochemical analysis of mismatch repair proteins in Iranian Colorectal Cancer patients at risk for Lynch syndrome [PDF]

, 2015
Background: Hereditary non-polyposis colorectal cancer (HNPCC) is a common hereditary cancer predisposing syndrome has molecular and clinicopathological features still have remained ambiguous within Iranian populations.
Emami, Mohammad Hassan., Hashemzadeh-Chaleshtori, Morteza., Naimi, Azar., Salehi, Rasoul., Zeinalian, Mehrdad.   +4 more
core   +1 more source

Human papilloma virus infection and mismatch repair protein expression in sebaceous neoplasms of the genital area

Histopathology, Volume 88, Issue 6, Page 1221-1228, May 2026.
This study establishes the role of high‐risk HPV infection in cutaneous sebaceous carcinoma of the genital area. An intraepithelial component in a subset of cases poses a challenge to distinguish the entity from squamous cell carcinoma in situ. Rarely, sebaceous neoplasia of the genital area is associated with Muir–Torre syndrome. Aims This study aimed
Katharina Wiedemeyer, Zainab Al‐Shamma, Martin Köbel, Ingrid Ferreira, Paul W. Harms, Thomas Brenn   +5 more
wiley   +1 more source

Precision immuno-oncology approach for four malignant tumors in siblings with constitutional mismatch repair deficiency syndrome

npj Precision Oncology
Constitutional mismatch repair deficiency (CMMRD) is a rare syndrome characterized by an increased incidence of cancer. It is caused by biallelic germline mutations in one of the four mismatch repair genes (MMR) genes: MLH1, MSH2, MSH6, or PMS2. Accurate
Hana Palova, Anirban Das, Petra Pokorna, Viera Bajciova, Zdenek Pavelka, Marta Jezova, Karol Pal, Jose R. Dimayacyac, Logine Negm, Lucie Stengs, Vanessa Bianchi, Klara Vejmelkova, Kristyna Noskova, Marie Jarosova, Sona Mejstrikova, Peter Mudry, Michal Kyr, Tomas Merta, Pavel Tinka, Klara Drabova, Stefania Aulicka, Robin Jugas, Uri Tabori, Ondrej Slaby, Jaroslav Sterba   +24 more
doaj   +1 more source

Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women [PDF]

, 2015
9Objective: To test the immunohistochemical staining pattern of some mismatch repair (MMR) system proteins in endometriotic tissue (ET) and eutopic endometrium.
Beltrami, Carlo Alberto, Calcagno, A., Canciani, G. N., Grassi, T., Londero, Ambrogio P., Marchesoni, Diego, Mariuzzi, Laura, Marzinotto, S., Orsaria, M.   +8 more
core  

Mismatch repair protein deficiency and its implications on distant metastasis in colorectal cancer: A comprehensive analysis

Cancer Medicine
Background While previous studies have indicated variability in distant metastatic potential among different mismatch repair (MMR) states in colorectal cancer (CRC), their findings remain inconclusive, especially considering potential differences across ...
Chuanwen Fan, Chao Fang, Wei Wang, Zhaoying Lv, Xueli Zhang, Feiwu Long, Zongze Jiang, Yuan Li, Hong Zhang, Zong‐Guang Zhou, Cun Wang, Xiao‐Feng Sun   +11 more
doaj   +1 more source

Evaluation of MT1XT20 single quasi-monomorphic mononucleotide marker for characterizing microsatellite instability in persian lynch syndrome patients [PDF]

, 2016
Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy.
Emami, Mohammad Hassan., Farahani, Najmeh., Hashemzadeh-Chaleshtori, Morteza., Nikpour, Parvaneh., Salehi, Rasoul., Shariatpanahi, Seyed Shervin., Zeinalian, Mehrdad.   +6 more
core  

Null Mismatch Repair Proteins Expression Reveals the Temporal Molecular Events in Lynch Syndrome-Related Cancers

Diagnostics
The immunohistochemical assessment of mismatch repair (MMR) proteins represents a pivotal screening tool for identifying Lynch syndrome (LS)-related cancers, as the loss of their expression often indicates MMR dysfunction associated with genetic or ...
Gianmaria Miolo, Wally Marus, Angela Buonadonna, Lucia Da Ros, Lara Della Puppa, Giuseppe Corona   +5 more
doaj   +1 more source

Integrated tumor and germline profiling of lynch syndrome in a North Indian cohort

Frontiers in Oncology
BackgroundLynch syndrome is the leading hereditary cause of colorectal and endometrial cancers, but data on germline mutations in the Indian population are insufficient. This study assessed patients with Lynch syndrome-related tumors using tumor mismatch
Himanshi Diwan, Anurag Mehta, Saudamini Sharma, Sakshi Mattoo, Shalini Agnihotri   +4 more
doaj   +1 more source

PMS2 Gene [PDF]

, 2020
openaire   +1 more source

PMS2 Gene Expression Analysis in Blood of Postmenopausal Women with Breast Cancer: A Comparative Study

Saudi Journal of Medicine
Background/aim: The PMS2 gene was evaluated for its role in the pathogenesis of breast cancer by analyzing its expression in blood samples obtained from healthy postmenopausal women, newly diagnosed breast cancer patients, and the same patients following surgical and therapeutic treatment.
Asma Asma, Shaukat Iqbal Malik, Mahnoor Fayyaz   +2 more
openaire   +1 more source