Results 121 to 130 of about 2,530,443 (206)

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

PMS2 and its role in mismatch repair deficiency syndrome

, 2011
The PMS2 protein IS a component of the post-replicative DNA mismatch repair (MMR) system, which acts to correct mispaired nucleotides and small insertion-deletion loops in new DNA duplexes.
Ingham, Danielle
core  

Dye tags influence single expression of MLH1 and PMS2.

, 2013
To determine the influence of fluorescent tags on single expressed MLH1 or PMS2 variants, HEK293T cells were transfected with different (A) MLH1 or (B) PMS2 constructs.
Ronja Adam (333161), Guido Plotz (22851), Inga Hinrichsen (333159), Angela Brieger (333158), Sandra Passmann (333160), Stefan Zeuzem (22856)   +5 more
core   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, Volume 110, Issue 3, Page 389-401, September 2026.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, Volume 89, Issue 3, Page 442-455, September 2026.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

Defect in the apoptotic response to cisplatin caused by the R20Q variant of the PMS2 protein

, 2008
Popravljači pogrešno sparenih baza (MMR) obavljaju popravak replikacijskih pogrešaka nastalih tijekom DNA sinteze. Isto tako, MMR proteini kod sisavaca imaju sposobnost aktivacije kontrolne točke staničnog ciklusa, te pokretanja apoptoze kao odgovora na ...
Marinović Terzić, Ivana
core   +3 more sources

Mismatch repair protein deficiency and its implications on distant metastasis in colorectal cancer: A comprehensive analysis

Cancer Medicine
Background While previous studies have indicated variability in distant metastatic potential among different mismatch repair (MMR) states in colorectal cancer (CRC), their findings remain inconclusive, especially considering potential differences across ...
Chuanwen Fan, Chao Fang, Wei Wang, Zhaoying Lv, Xueli Zhang, Feiwu Long, Zongze Jiang, Yuan Li, Hong Zhang, Zong‐Guang Zhou, Cun Wang, Xiao‐Feng Sun   +11 more
doaj   +1 more source

PMS2 Gene Expression Analysis in Blood of Postmenopausal Women with Breast Cancer: A Comparative Study

Saudi Journal of Medicine
Background/aim: The PMS2 gene was evaluated for its role in the pathogenesis of breast cancer by analyzing its expression in blood samples obtained from healthy postmenopausal women, newly diagnosed breast cancer patients, and the same patients following surgical and therapeutic treatment.
Asma Asma, Shaukat Iqbal Malik, Mahnoor Fayyaz   +2 more
openaire   +1 more source

Null Mismatch Repair Proteins Expression Reveals the Temporal Molecular Events in Lynch Syndrome-Related Cancers

Diagnostics
The immunohistochemical assessment of mismatch repair (MMR) proteins represents a pivotal screening tool for identifying Lynch syndrome (LS)-related cancers, as the loss of their expression often indicates MMR dysfunction associated with genetic or ...
Gianmaria Miolo, Wally Marus, Angela Buonadonna, Lucia Da Ros, Lara Della Puppa, Giuseppe Corona   +5 more
doaj   +1 more source

PMS2 Gene [PDF]

, 2020
openaire   +1 more source