Results 131 to 140 of about 2,990 (173)

Predicting pyrazinamide resistance in Mycobacterium tuberculosis using a graph convolutional network

Dissanayake D, Brunner V, Adlard D, Adlard D, Morrone JA, Fowler PW.   +5 more
europepmc   +1 more source

Mechanism of the dual action self-potentiating antitubercular drug morphazinamide. [PDF]

PNAS Nexus
Ostrer L, Crooks TA, Howe MD, Vo S, Jia Z, Hegde P, Schacht N, Aldrich CC, Baughn AD.   +8 more
europepmc   +1 more source

Whole-genome sequencing reveals lineage-associated drug resistance and enables machine learning-based prediction in <i>Mycobacterium tuberculosis</i> clinical isolates. [PDF]

Front Microbiol
Hao Z, Wu C, Peng Y, Zhou L, Li J, Zou X.   +5 more
europepmc   +1 more source

The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China. [PDF]

Emerg Microbes Infect
Wang N, Meng F, Deng L, Wu L, Yang Y, Li H, Chen Y, Wei Z, Xie B, Gong L, Niu Q, Lei J, Gao J, Huang B, Wang Q, Lai X, Liu Z, Hu J.   +17 more
europepmc   +1 more source

Determining the minimum inhibitory concentrations of pyrazinamide against <i>Mycobacterium tuberculosis</i> clinical isolates at a neutral pH of 6.8 using the broth microdilution method. [PDF]

Front Microbiol
Tamblin M, Shi W, Chen L, Reynolds J.
europepmc   +1 more source

Phenotypic and genotypic characterization of Mycobacterium tuberculosis pyrazinamide resistance-India, 2018-2020. [PDF]

Front Microbiol
Tamilzhalagan S, Justin ES, Selvaraj A, Venkateswaran K, Sivakumar AK, Chittibabu S, McLaughlin HP, Moonan PK, Smith JP, Suba S, Sathya Narayanan MK, Ho CS, Kumar N, Tripathy SP, Shanmugam SK, Hall-Eidson PJ, Ranganathan UD.   +16 more
europepmc   +1 more source

<i>In silico</i> analysis of the functional implications of drug resistance associated mutations in <i>Mycobacterium tuberculosis</i>. [PDF]

Comput Struct Biotechnol J
Pal A, Pal S, Mahapatra S, Pandey A, Mohanty D.   +4 more
europepmc   +1 more source

Tracking cross-border transmission of Rwanda’s successful dominant rifampicin-resistant Mycobacterium tuberculosis clone using genomic markers

Cuella-Martin I, Mulders W, Keysers J, Hakizayezu F, Niyompano H, Runyambo D, De Rijk WB, Phelan J, Mucyo Habimana Y, Migambi P, Sawadogo M, Mambo Muvunyi C, de Jong BC, Ngabonziza JCS, Rigouts L, Meehan CJ.   +15 more
europepmc   +1 more source

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

Nature Communications, 2017
AbstractTuberculosis chemotherapy is dependent on the use of the antibiotic pyrazinamide, which is being threatened by emerging drug resistance. Resistance is mediated through mutations in the bacterial gene pncA. Methods for testing pyrazinamide susceptibility are difficult and rarely performed, and this means that the full spectrum of pncA alleles ...
Eric Rubin, James Sacchettini, John H Adamson   +2 more
exaly   +6 more sources

Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA [PDF]

Microbiology (United Kingdom), 2011
The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD+ homeostasis and contributes to numerous important biological processes in diverse organisms. In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle.
Patricia A Rosa, Mollie W Jewett
exaly   +4 more sources