Results 131 to 140 of about 2,913 (168)

TOAST: a novel tool for designing targeted gene amplicons and an optimised set of primers for high-throughput sequencing in tuberculosis genomic studies. [PDF]

BMC Genomics
Wang L, Thawong N, Thorpe J, Higgins M, Ik MTK, Sawaengdee W, Mahasirimongkol S, Perdigão J, Campino S, Clark TG, Phelan JE.   +10 more
europepmc   +1 more source

Correction: Associations Among Diet, Health, Lifestyle, and Gut Microbiota Composition in the General French Population: Protocol for the Le French Gut - Le Microbiote Français Study. [PDF]

JMIR Res Protoc
Connan C, Fromentin S, Benallaoua M, Alvarez AS, Pons N, Quinquis B, Morabito C, Nazare JA, Borezée-Durant E, Le French Gut Consortium, Haimet F, Ehrlich SD, Valeille K, Cavezza A, Blottière H, Veiga P, Almeida M, Doré J, Benamouzig R.   +18 more
europepmc   +1 more source

Evaluation of Whole Genome Sequencing-Based Predictions of Antimicrobial Resistance to TB First Line Agents: A Lesson from 5 Years of Data. [PDF]

Int J Mol Sci
Sharma MK, Stobart M, Akochy PM, Adam H, Janella D, Rabb M, Alawa M, Sekirov I, Tyrrell GJ, Soualhine H.   +9 more
europepmc   +1 more source

Quantitative MODS-Wayne assay for rapid detection of pyrazinamide resistance in <i>Mycobacterium tuberculosis</i> from sputum samples. [PDF]

Microbiol Spectr
Toscano-Guerra E, Alcántara R, Untiveros KL, Gilman R, Grandjean L, Zimic M, Sheen P.   +6 more
europepmc   +1 more source

Genomic insights into extrapulmonary tuberculosis reveal enrichment of lineage 2 with high drug resistance in specific clinical phenotypes

Sharma K, Bandari A, Manjunath GK, Rastogi M, Babu AS, Ponnusamy P, Vasanthaiah S, Vasudevan K, Yadav P, George J, Kumar A, Sharma J, Sharma A, Modi M, Gupta A, Singh R, Sinha SK, Dhillon MS, Sharma M, Sharma V, Nada R, Sharma N, Pandey A, Verma R.   +23 more
europepmc   +2 more sources

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Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis

Biochemical and Biophysical Research Communications, 2018
The nicotinamidase/pyrazinamidase PncA is a member of a large family of hydrolase enzymes that catalyze the deamination of nicotinamide to nicotinic acid. PncA also functions as a pyrazinamidase in a wide variety of eubacteria and is an essential coenzyme in many cellular redox reactions in living systems.
Yuesheng Dong, Yongbin Xu, Chunshan Quan   +2 more
exaly   +3 more sources

Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA [PDF]

Microbiology (United Kingdom), 2011
The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD+ homeostasis and contributes to numerous important biological processes in diverse organisms. In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle.
Patricia Rosa, Mollie Jewett
exaly   +4 more sources

Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy, 1997
Pyrazinamide (PZA) is a first-line drug for short-course tuberculosis therapy. Resistance to PZA is usually accompanied by loss of pyrazinamidase (PZase) activity in Mycobacterium tuberculosis. PZase converts PZA to bactericidal pyrazinoic acid, and the loss of PZase activity is associated with PZA resistance.
A, Scorpio, P, Lindholm-Levy, L, Heifets, R, Gilman, S, Siddiqi, M, Cynamon, Y, Zhang   +6 more
openaire   +2 more sources

Drug resistance mechanism of PncA inMycobacterium tuberculosis

Journal of Biomolecular Structure and Dynamics, 2013
Tuberculosis continues to be a global health threat. Pyrazinamide (PZA) is an important first-line drug in multidrug-resistant tuberculosis treatment. The emergence of strains resistant to PZA represents an important public health problem, as both first- and second-line treatment regimens include PZA. It becomes toxic to Mycobacterium tuberculosis when
Vidya, Rajendran, Rao, Sethumadhavan
openaire   +2 more sources