Results 151 to 160 of about 2,990 (173)

[Studies on pncA gene mutations in M. tuberculosis isolates].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2002
To understand the mutations of pncA gene in M. tuberculosis isolates, and to evaluate their clinical value.Analyzing the pncA genes in 74 M. tuberculosis clinical isolates with PCR-SSCP and PCR-AS. M. tuberculosis strain H37Rv was used as control.32 drug-sensitive isolates all displayed normal pncA SSCP profile.
X, Wu, J, Zhang, M, Zhong
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Study of the structure–activity relationships for the pyrazinamidase (PncA) from Mycobacterium tuberculosis

Biochemical Journal, 2001
In an attempt to investigate the molecular basis of pyrazinamide hydrolysis by the PncA protein from Mycobacterium tuberculosis, we determined the pyrazinamidase activity of nine PncA mutants bearing a single amino acid substitution. Among them, three mutants (D8G, K96T and S104R) had virtually no activity (⩽ 0.004unit/mg), five (F13S, T61P, P69L ...
Nadine LEMAITRE, Isabelle CALLEBAUT, Frédéric FRENOIS, Vincent JARLIER, Wladimir SOUGAKOFF   +4 more
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The use of PNCA in neonatal postoperative pain management

The Journal of Pain, 2012
M. Czarnecki, K. Hainsworth, M. Arca, M. Uhing, J. Varadarajan, P. Simpson, S. Weisman   +6 more
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Detection of Mutations in pncA in Mycobacterium tuberculosis Clinical Isolates from Nepal in Association with Pyrazinamide Resistance

Current Issues in Molecular Biology, 2022
Yasuhiko Suzuki, Bhagwan Maharjan, Joseph Yamweka Chizimu   +2 more
exaly  

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Frontiers in Microbiology, 2021
Jiaoyu Deng
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Novel pncA Mutations in Pyrazinamide-Resistant Isolates of Mycobacterium tuberculosis.

Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology
The gene coding for pyrazinamidase (PZase) activity, pncA, in Mycobacterium tuberculosis was recently cloned, and several mutations which correlate with in vitro resistance to pyrazinamide (PZA) have been identified. During the development of a clinical molecular assay for the detection of PZA resistance, two previously unreported mutations in isolates
, Sachais, , Nachamkindagger, , Mills, , Leonard   +3 more
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Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from Korea and analysis of the correlation between the mutations and pyrazinamidase activity

World Journal of Microbiology and Biotechnology, 2014
Ji-Sun Nam
exaly  

Crystal structure of the nicotinamidase/pyrazinamidase PncA from

Biochemical and Biophysical Research Communications, 2018
Yuesheng Dong, Yongbin Xu, Chunshan Quan
exaly  

Mutations Found in the pncA Gene of Mycobacterium tuberculosis in Clinical Pyrazinamide-resistant Isolates from a Local Region of China

Journal of International Medical Research, 2009
Xian-En Zhang
exaly  

Non-pncA Gene-Mutated but Pyrazinamide-Resistant Mycobacterium tuberculosis: Why Is That?

Journal of Clinical Microbiology, 2017
Mikael Mansjö, Erik Alm, Jim Werngren
exaly