Results 161 to 170 of about 5,852 (197)

Identification and drug resistance profiling of <i>Mycobacterium orygis</i> from an African elephant using whole-genome sequencing. [PDF]

Microbiol Spectr
Ghayas H, Ashraf J, Saeed N, Zaka S, Shafiq S, Farooqi J, Jabeen K, Rais A, Rizvi AI, Mustafa G, Qureshi SA, Askari Y, Salahuddin N, Ozer EA, Hasan R.   +14 more
europepmc   +1 more source

Comparative genomics of Borrelia lusitaniae. [PDF]

G3 (Bethesda)
Lopes de Carvalho I, Núncio MS, Norte AC, Mongodin EF, Luft BJ, Schutzer SE, Yang X, Fraser CM, Hepner S, Fingerle V, Margos G, Morgan R, Akther S, Qiu W, Casjens SR.   +14 more
europepmc   +1 more source

Genomic insights into extrapulmonary tuberculosis reveal enrichment of lineage 2 with high drug resistance in specific clinical phenotypes

Sharma K, Bandari A, Manjunath GK, Rastogi M, Babu AS, Ponnusamy P, Vasanthaiah S, Vasudevan K, Yadav P, George J, Kumar A, Sharma J, Sharma A, Modi M, Gupta A, Singh R, Sinha SK, Dhillon MS, Sharma M, Sharma V, Nada R, Sharma N, Pandey A, Verma R.   +23 more
europepmc   +2 more sources

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide [PDF]

Nature Communications, 2017
AbstractTuberculosis chemotherapy is dependent on the use of the antibiotic pyrazinamide, which is being threatened by emerging drug resistance. Resistance is mediated through mutations in the bacterial gene pncA. Methods for testing pyrazinamide susceptibility are difficult and rarely performed, and this means that the full spectrum of pncA alleles ...
John H Adamson, James C Sacchettini, Thomas R Ioerger   +2 more
exaly   +9 more sources

Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA [PDF]

Microbiology (United Kingdom), 2011
The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD+ homeostasis and contributes to numerous important biological processes in diverse organisms. In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle.
Mollie W Jewett
exaly   +8 more sources

Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution? [PDF]

Journal of Antimicrobial Chemotherapy, 2005
Introduction: It is perceived wisdom that within the host macrophage, Mycobacterium tuberculosis frequently encounters oxidative stress. Exposure of bacteria to reactive oxygen intermediates can have a mutagenic effect on the DNA.
Timothy D Mchugh, Stephen H Gillespie, Mchugh Timothy D   +2 more
exaly   +2 more sources

Pyrazinamide Susceptibility and pncA Mutation Profiles of Mycobacterium tuberculosis among Multidrug-Resistant Tuberculosis Patients in Bangladesh [PDF]

Antimicrobial Agents and Chemotherapy, 2017
Pyrazinamide (PZA) is a frontline antituberculosis (anti-TB) drug used in both first- and second-line treatment regimens. However, due to complex laboratory requirements, the PZA susceptibility test is rarely performed, leading to a scarcity of data on ...
Arfatur Rahman, Shahriar Ahmed, S M Mazidur Rahman   +2 more
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis

Biochemical and Biophysical Research Communications, 2018
The nicotinamidase/pyrazinamidase PncA is a member of a large family of hydrolase enzymes that catalyze the deamination of nicotinamide to nicotinic acid. PncA also functions as a pyrazinamidase in a wide variety of eubacteria and is an essential coenzyme in many cellular redox reactions in living systems.
Jinli Chen, Lulu Wang, Liming Jin
exaly   +3 more sources

Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy, 1997
Pyrazinamide (PZA) is a first-line drug for short-course tuberculosis therapy. Resistance to PZA is usually accompanied by loss of pyrazinamidase (PZase) activity in Mycobacterium tuberculosis. PZase converts PZA to bactericidal pyrazinoic acid, and the loss of PZase activity is associated with PZA resistance.
A, Scorpio, P, Lindholm-Levy, L, Heifets, R, Gilman, S, Siddiqi, M, Cynamon, Y, Zhang   +6 more
openaire   +2 more sources