Stem cell-derived brain-like endothelial cells to interrogate Streptococcus pneumoniae interaction with brain endothelium [PDF]
VirulenceStreptococcus pneumoniae (pneumococcus) is an opportunistic pathogen that remains the leading cause of bacterial meningitis worldwide. For meningitis to occur, pneumococcus must breach the blood-brain barrier (BBB), a highly specialized network of brain ...
Henry D. Mauser +10 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2021 Streptococcus pneumoniae (also called pneumococcus) is not only a commensal that frequently colonizes the human upper respiratory tract but also a pathogen that causes pneumonia, sepsis, and meningitis.
Ayumi Morimura +3 more
exaly +2 more sources
PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis
Particle and Fibre Toxicology, 2020 Background Pneumococcus is one of the most common human airway pathogens that causes life-threatening infections. Ambient fine particulate matter (PM) with aerodynamic diameter ≤ 2.5 μm (PM2.5) is known to significantly contribute to respiratory diseases.
Yu-Wen Chen +11 more
doaj +2 more sources
Inflammation induced by influenza virus impairs human innate immune control of pneumococcus
Nature Immunology, 2018 Colonization of the upper respiratory tract by pneumococcus is important both as a determinant of disease and for transmission into the population. The immunological mechanisms that contain pneumococcus during colonization are well studied in mice but ...
Simon P Jochems +2 more
exaly +2 more sources
The metabolic, microbial and immunological demands of pneumococcal colonisation. [PDF]
PLoS PathogensStreptococcus pneumoniae (the pneumococcus) causes a range of life-threatening diseases including pneumonia, sepsis and meningitis. Despite widespread vaccine deployment, pneumococcal disease remains a leading cause of global mortality.
Daniel R Neill, Thomas B Clarke
doaj +2 more sources
Insights into the Interaction between Influenza Virus and Pneumococcus
Clinical Microbiology Reviews, 2006 Jonathan A. McCullers
exaly +3 more sources
Unraveling the seasonal epidemiology of pneumococcus
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The pneumococcus, a bacterium frequently carried in the nasopharynx, is responsible for a wide spectrum of infections in humans, including severe invasive pneumococcal diseases (IPDs). In nontropical climates, IPDs typically display a marked
Matthieu Domenech de Cellès +2 more
exaly +2 more sources
Variation of growth characteristics of pneumococcus with environmental conditions [PDF]
BMC Microbiology, 2019 Pneumococcus is exposed to a variety of temperature and oxygen levels in the upper respiratory tract and as it invades the lung, tissues, and blood.
Adrienn Tóthpál +4 more
openalex +2 more sources
Influence of Obesity on Pneumococcus Infection Risk in the Elderly
Frontiers in Endocrinology, 2019 Obesity negatively affects immune function and host defense mechanisms. Obesity is associated with chronic activation of the innate immune system and consequent local and systemic inflammation which contribute to pathologic conditions such as type-2 ...
Daniela Frasca
exaly +2 more sources
Molecular typing of the pneumococcus and its application in epidemiology in sub-Saharan Africa
Frontiers in Cellular and Infection Microbiology, 2013 Molecular typing of the pneumococcus has played a crucial role in understanding the epidemiology of the organism. However, most of what is known about molecular epidemiology of the pneumococcus pertains to the developed world.
Eric S Donkor
exaly +3 more sources