Results 111 to 120 of about 49,296 (330)

Late diagnosis of paediatric HIV infection in high‐income countries: Lessons from the HIV Perinatal Virtual Clinic

HIV Medicine, EarlyView.
Abstract Introduction Timely diagnosis of HIV in children remains a challenge in all settings including low‐prevalence, high‐income countries (HIC). We aimed to characterize the prevalence of late diagnosis, and prior missed diagnostic opportunities among new presentations of paediatric HIV in HIC referred to an international Perinatal Virtual Clinic ...
Carolina Curto, M. Tritzali, A. Bamford, A. C. Bailey, E. G. H. Lyall, N. E. Mackie, N. Tickner, C. Foster, on behalf of the PVC   +8 more
wiley   +1 more source

Protein conjugate polysaccharide vaccines: Challenges in development and global implementation

Indian Journal of Community Medicine, 2012
Pneumonia and meningitis caused by Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis are among the leading causes of under five mortality and morbidity.
Manisha Nair
doaj   +1 more source

In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection [PDF]

, 2019
An overt pro-inflammatory immune response is a key factor contributing to lethal pneumococcal infection in an influenza pre-infected host and represents a potential target for therapeutic intervention.
Boehme, Julia D., Bruder, Dunja, Christen, Henrike, Guzmán, Carlos A., Hernandez-Vargas, Esteban A., Kershaw, Olivia, Schreiber, Jens, Sharma-Chawla, Niharika, Stegemann-Koniszewski, Sabine   +8 more
core   +1 more source

RESULTS OF PROPHYLACTIC INOCULATION AGAINST PNEUMOCOCCUS IN 12,519 MEN

Journal of Experimental Medicine, 1918
1. From a study of the agglutinins and protective power of the serum of 42 persons vaccinated against the pneumococcus, Types I, II, and III, it is demonstrated that a definite immune response has been secured to Types I and II by the dose of vaccine ...
R. Cecil, J. Harold Austin
semanticscholar   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling

Frontiers in Immunology, 2017
Streptococcus pneumoniae (Spn) causes a variety of disease states including fatal bacterial pneumonia. Our previous finding that introduction of Spn into an animal with ongoing influenza virus infection resulted in a CD8+ T cell population with reduced ...
Lance K. Blevins, Derek Parsonage, Melissa B. Oliver, Elizabeth Domzalski, W. Edward Swords, Martha A. Alexander-Miller   +5 more
doaj   +1 more source

The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui, Marnie Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Akira Sekikawa, Tullia C. Bruno, Toren Finkel, Anne B. Newman   +11 more
wiley   +1 more source

A 3’UTR-derived small RNA represses pneumolysin synthesis and facilitates pneumococcal brain invasion

Communications Biology
Pneumolysin (Ply) of Streptococcus pneumoniae (pneumococcus) at relatively high and low levels facilitates pneumococcal invasion into the lung and brain, respectively; however, the regulatory mechanisms of Ply expression are poorly understood.
Kaiqiang Shen, Wenshuang Miao, Lin Zhu, Qingqing Hu, Fu Ren, Xiuzhu Dong, Huichun Tong   +6 more
doaj   +1 more source

An outbreak of pneumococcal meningitis among older children (≥5 years) and adults after the implementation of an infant vaccination programme with the 13-valent pneumococcal conjugate vaccine in Ghana. [PDF]

, 2016
BACKGROUND: An outbreak of pneumococcal meningitis among non-infant children and adults occurred in the Brong-Ahafo region of Ghana between December 2015 and April 2016 despite the recent nationwide implementation of a vaccination programme for infants ...
Afreh, Osei Kuffour, Amponsa-Achiano, Kwame, Antonio, Martin, Appiah-Denkyira, Ebenezer, Asiedu-Bekoe, Franklin, Bampoe, Victor, Bannerman, Richard, D'Alessandro, Umberto, Ebruke, Chinelo, Foster-Nyarko, Ebenezer, Kaluwa, Owen, Kay, Gemma, Kuma, George Khumalo, Kwambana-Adams, Brenda Anna, Letsa, Timothy, Mwenda, Jason M, Ohene, Sally-Ann, Okoi, Catherine, Okot, Charles, Opare, David, Otu, Jacob Kweku, Owusu-Okyere, Godfred, Pallen, Mark J, Sarkodie, Badu, Senghore, Madikay, Worwui, Archibald Kwame, Zaman, Syed MA   +26 more
core   +2 more sources

ACTIVE AND PASSIVE IMMUNITY TO PNEUMOCOCCUS INFECTION INDUCED IN RABBITS BY IMMUNIZATION WITH R PNEUMOCOCCI

Journal of Experimental Medicine, 1928
1. Rabbits, vaccinated by repeated intravenous injections of suspensions of heat-killed R pneumococci, acquire a marked degree of active immunity to infection with the virulent S forms of Pneumococcus Types I and II.
W. Tillett
semanticscholar   +1 more source