Results 31 to 40 of about 22,008 (204)

Etiological role and molecular-genetic features of Streptococcus pneumoniae in children’s infectious diseases

Детские инфекции (Москва), 2020
Objective: To study the etiological role, serotype distribution and prevalent Streptococcus pneumoniae genotypes (sequence types) in 459 children hospitalized with acute purulent otitis media, acute tonsillitis, community-acquired pneumonia, and purulent
I. N. Protasova, G. P. Martynova, N. A. Ilyenkova, I. A. Kutischeva, S. V. Domracheva, O. P. Ovchinnikova, E. S. Sokolovskaya   +6 more
doaj   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Streptococcus pneumoniae Proteins AmiA, AliA, and AliB Bind Peptides Found in Ribosomal Proteins of Other Bacterial Species

Frontiers in Microbiology, 2018
The nasopharynx is frequently colonized by both commensal and pathogenic bacteria including Streptococcus pneumoniae (pneumococcus). Pneumococcus is an important pathogen responsible for bacterial meningitis and community acquired pneumonia but is also ...
Fauzy Nasher, Fauzy Nasher, Manfred Heller, Lucy J. Hathaway   +3 more
doaj   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

A low-cost culture- and DNA extraction-free method for the molecular detection of pneumococcal carriage in saliva

Microbiology Spectrum
Molecular methods have improved the sensitivity of the detection of pneumococcal carriage in saliva. However, they typically require sample culture enrichment and nucleic acid extraction prior to performing the detection assay and may limit scalability ...
Chikondi Peno, Tzu-Yi Lin, Maikel S. Hislop, Devyn Yolda-Carr, Katherine Farjado, Anna York, Virginia E. Pitzer, Daniel M. Weinberger, Amy K. Bei, Orchid M. Allicock, Anne L. Wyllie   +10 more
doaj   +1 more source

Scheduling early primary care follow‐up after pneumonia: A retrospective target trial emulation in five hospitals

Journal of Hospital Medicine, EarlyView.
Abstract Background Current guidelines make no recommendations on discharge interventions or scheduling outpatient follow‐up after hospitlization for commnity‐acquired pneumonia (CAP). Objectives To assess the impact of scheduling early primary care follow‐up prior to discharge home among survivors of hypoxemic CAP hospitalizations.
Andrew J. Davis, Stephanie P. Taylor, Catherine L. Hough, Mari Armstrong‐Hough, Li Yan, Catherine K. Ettman, Katy Sadowski, Khyzer B. Aziz, Patrick G. Lyons, Katrina E. Hauschildt, Marc Kowalkowski, Eliana M. Perrin, Theodore J. Iwashyna   +12 more
wiley   +1 more source

Trends in hospitalizations for vaccine‐preventable diseases in the United States from 2014 to 2024

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Vaccination rates have declined in recent years, resulting in outbreaks of vaccine‐preventable diseases (VPDs) among children. We aimed to evaluate VPD hospitalization rates from 2014 to 2024 and to report associated trends in outcomes including intensive care utilization, mortality, readmissions, and costs.
Nathan M. Money, Erin Sullivan, Hannah Rector, Corrie E. McDaniel, Jessica L. Markham, Mersine A. Bryan   +5 more
wiley   +1 more source

Serological immunity against vaccine‐preventable diseases in children with inflammatory bowel disease at diagnosis

JPGN Reports, EarlyView.
Abstract Objectives Patients with inflammatory bowel disease (IBD) are at increased risk of vaccine‐preventable diseases. However, vaccination coverage in this population is often suboptimal. This retrospective study assessed the vaccination status and vaccine serology of children diagnosed with IBD in a high‐income country with broad vaccine access ...
Clara Noble, Renato Gualtieri, Klara Posfay‐Barbe, Nathalie Rock, Geraldine Blanchard‐Rohner   +4 more
wiley   +1 more source

Pneumococcal Vaccines: Past Findings, Present Work, and Future Strategies

Vaccines, 2021
The importance of Streptococcus pneumoniae has been well established. These bacteria can colonize infants and adults without symptoms, but in some cases can spread, invade other tissues and cause disease with high morbidity and mortality. The development
Giuliana S. Oliveira, Maria Leonor S. Oliveira, Eliane N. Miyaji, Tasson C. Rodrigues   +3 more
doaj   +1 more source

Targeting the Dynamic Susceptibility Window: Time‐Sensitive Photodynamic Synergy With Antibiotics Against Streptococcus spp

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objective Evaluated the antimicrobial efficacy of curcumin‐mediated photodynamic inactivation (PDI) against both sensitive and resistant strains of Streptococcus pneumoniae and Streptococcus pyogenes, as well as its potential to enhance antibiotic effects (amoxicillin, ceftriaxone, erythromycin).
Isabella S. Gonçalves, Jennifer M. Soares, Vanderlei S. Bagnato, Kate C. Blanco   +3 more
wiley   +1 more source