Results 91 to 100 of about 62,491 (234)

Comparative Population Genomics Analysis of the Mammalian Fungal Pathogen Pneumocystis

mBio, 2018
Pneumocystis species are opportunistic mammalian pathogens that cause severe pneumonia in immunocompromised individuals. These fungi are highly host specific and uncultivable in vitro.
Ousmane H. Cissé, Liang Ma, Da Wei Huang, Pavel P. Khil, John P. Dekker, Geetha Kutty, Lisa Bishop, Yueqin Liu, Xilong Deng, Philippe M. Hauser, Marco Pagni, Vanessa Hirsch, Richard A. Lempicki, Jason E. Stajich, Christina A. Cuomo, Joseph A. Kovacs   +15 more
doaj   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1487-1492, May 2026.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Nosocomial Pneumocystis jirovecii infections

Parasite, 2008
Airborne transmission of Pneumocystis sp. from host to host has been demonstrated in rodent models and several observations suggest that interindividual transmission occurs in humans.
Nevez G., Chabé M., Rabodonirina M., Virmaux M., Dei-Cas E., Hauser P.M., Totet A.   +6 more
doaj   +1 more source

A novel case of autosomal recessive CARD11 loss‐of‐function underlying impaired antiviral immunity and a review of literature

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
We report on a patient homozygous for a novel autosomal recessive loss‐of‐function CARD11 variant, with susceptibility to live attenuated virus (LAV) vaccines and impaired clearance of multiple naturally acquired respiratory viral infections. Inborn errors of immunity affecting the CARD11‐BCL10‐MALT1 (CBM) complex should be considered in individuals ...
Hamish Anderson, Cecilia Verryt, Paula Keating, Thomas Saunders, Samuel Dalton, Barry D Hock, Liping Goddard, Kylie Drake, Anja Werno, John O'Donnell, Jeffrey R Stinson, Andrew L Snow, Kuang‐Chih Hsiao   +12 more
wiley   +1 more source

Outbreaks of Pneumocystis Pneumonia in 2 Renal Transplant Centers Linked to a Single Strain of Pneumocystis: Implications for Transmission and Virulence [PDF]

, 2017
By restriction fragment length polymorphism analysis, 2 outbreaks of Pneumocystis pneumonia in renal transplant patients in Europe were shown to be caused by the same strain of Pneumocystis; another outbreak in Japan was caused by a different ...
Fehr, Thomas, Gianella, Sara, Gogineni, Emile, Goto, Norihiko, Huber, Charles, Konrad, Regina, Kovacs, Joseph A., Kutty, Geetha, Ma, Liang, Mueller, Nicolas J., Oka, Shinichi, Ripamonti, Chiara, Sassi, Monica, Sing, Andreas, Yazaki, Hirohisa   +14 more
core  

Activated immune cells present a lung interstitial‐to‐airway/alveolar cross‐compartment sharing pattern in severe pneumonia

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
The interstitial‐to‐airway cross‐compartment sharing pattern of activated immune cells provides new insights for severe pneumonia. Macrophages could amplify local immune response by recruiting specific activated immune cells via CXCL10–CXCR3 signalling into airway, while other immune cells reside with limited inflammatory activity.
Yuean Zhao, Linjing Gong, He Yu, Sifan Zhang, Guanglei Yang, Chaoyang Wang, Weiya Wang, Xuyu Cai, Ye Wang   +8 more
wiley   +1 more source

Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages

BMC Microbiology, 2010
Background Pneumocystis pneumonia is a common opportunistic disease in AIDS patients. The alveolar macrophage is an important effector cell in the clearance of Pneumocystis organisms by phagocytosis.
Liao Chung-Ping, Xuei Xiaoling, Liu Yunlong, Cheng Bi-Hua, Lu Debao, Lasbury Mark E, Durant Pamela J, Lee Chao-Hung   +7 more
doaj   +1 more source

Torque Teno Virus in Bronchoalveolar Lavage Fluid of Hematological Patients and Association With Pathogens

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Torque teno virus (TTV) replication is tightly modulated by the host immune response. As such, TTV viremia has been investigated as a biomarker of immune competence for monitoring the risks of allograft rejection and opportunistic infections in solid organ transplant recipients.
Mahdi Ouafi, Camille Cordier, David Beauvais, Serge Alfandari, Marie Titécat, Romain Dubois, Frédéric Wallyn, Séverine Loridant, Fanny Vuotto, Micha Srour, Céline Berton, Valérie Coiteux, Ibrahim Yakoub‐Agha, Boualem Sendid, Didier Hober, Enagnon Kazali Alidjinou   +15 more
wiley   +1 more source

Serum-based diagnosis of Pneumocystis pneumonia by detection of Pneumocystis jirovecii DNA and 1,3-β-D-glucan in HIV-infected patients: a retrospective case control study

BMC Infectious Diseases, 2019
Background Pneumocystis jirovecii pneumonia (PCP) is one of the most common HIV-related opportunistic infections. The diagnosis of PCP is based on analyses from respiratory tract specimens which may require the invasive procedure of a diagnostic ...
Helena Hammarström, Anna Grankvist, Isabell Broman, Nahid Kondori, Christine Wennerås, Magnus Gisslen, Vanda Friman   +6 more
doaj   +1 more source

Efficacy of upadacitinib induction for pediatric inflammatory bowel disease

JPGN Reports, Volume 7, Issue 2, Page 296-300, May 2026.
Abstract Objectives Upadacitinib, a second‐generation Janus kinase (JAK) inhibitor, is approved for moderate to severe Crohn's disease (CD) and ulcerative colitis (UC) in adults. Its efficacy in pediatric patients remains unclear, though early reports suggest benefits in refractory inflammatory bowel disease (IBD).
Evan Greenhall, Nina Gautam, Paula Prieto‐Jimenez, Elizabeth Hilow, Ashish Patel, Brad Pasternak   +5 more
wiley   +1 more source