Results 71 to 80 of about 20,563 (225)

Identification and Functional Ascertainment of the Pneumocystis jirovecii Potential Drug Targets Gsc1 and Kre6 Involved in Glucan Synthesis. [PDF]

, 2017
The most efficient drug against the human pathogenic fungus Pneumocystis jirovecii is cotrimoxazole targeting the folate biosynthesis. However, resistance toward it is emerging and adverse effects occur in some patients.
Cissé, O.H., Hauser, P.M., Luraschi, A., Pagni, M.   +3 more
core   +1 more source

Isocitrate Dehydrogenase‐Mutant Astrocytomas: Risk Stratification and Therapeutic Advance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract synthesizes the core logic of our revised review by linking integrated diagnosis, risk stratification, and trajectory‐based management in IDH‐mutant astrocytomas across CNS WHO Grades 2–4. It highlights lineage‐defining molecular classification (IDH mutation with core co‐alterations), integrated histomolecular grading, and key ...
Shepeng Wei, Xuxu Xu, Jing Bao, Zhenjiang Pan   +3 more
wiley   +1 more source

Newly formed cystic lesions for the development of pneumomediastinum in Pneumocystis jirovecii pneumonia

BMC Infectious Diseases, 2009
Background Pneumocystis jirovecii, formerly named Pneumocystis carinii, is one of the most common opportunistic infections in human immunodeficiency virus (HIV)-infected patients.
Yoon Sung, Kwon Yong, Kim Dong-Min, Cho Ju-Yeon, Lee Seung   +4 more
doaj   +1 more source

Detection of Pneumocystis jirovecii by Two Staining Methods and Two Quantitative PCR Assays [PDF]

, 2018
: Background: : Pneumocystis jirovecii is an opportunistic pathogen that causes pneumonia, particularly in immunodeficient hosts. Materials and Methods: : We retrospectively compared the results obtained by two staining methods (toluidine blue and ...
Graf, J.-D, Jacomo, V., Rohner, P., Schrenzel, J., Studer, R.   +4 more
core  

Amiodarone‐Induced Pulmonary Toxicity With Confirmed Elevated Plasma Mono‐Desethyl‐Amiodarone Levels

Respirology Case Reports, Volume 14, Issue 4, April 2026.
We report a case of pulmonary toxicity that developed 10 months after the initiation of amiodarone. The serum mono‐desethyl‐amiodarone concentration was elevated despite the relatively low cumulative amiodarone dose. ABSTRACT Amiodarone hydrochloride is an effective antiarrhythmic drug that can cause serious adverse effects, including amiodarone ...
Munechika Hara, Miki Kato, Fumika Sugiyama, Ryo Ichikawa, Tsutomu Hachiya   +4 more
wiley   +1 more source

Molecular detection of Pneumocystis jirovecii using polymerase chain reaction in immunocompromised patients with pulmonary disorders in northeast of Iran

Current Medical Mycology, 2015
Background and Purpose: Pneumocystis pneumonia, caused by Pneumocystis jirovecii, is a fatal disease threatening patients with AIDS or immunosuppression.
Mahmood Parian, Abdolmajid Fata, Mohammad Javad Najafzadeh, Fariba Rezaeitalab   +3 more
doaj  

Pneumocystis jirovecii Transmission from Immunocompetent Carriers to Infant

Emerging Infectious Diseases, 2008
We report a case of Pneumocystis jirovecii transmission from colonized grandparents to their infant granddaughter. Genotyping of P. jirovecii showed the same genotypes in samples from the infant and her grandparents. These findings support P.
Laura Rivero, Carmen de la Horra, Marco A. Montes-Cano, Alfonso Rodríguez-Herrera, Nieves Respaldiza, Vicente Friaza, Rubén Morilla, Sonia Gutiérrez, José M. Varela, Francisco J. Medrano, Enrique J. Calderón   +10 more
doaj   +1 more source

Rising Prevalence of Pneumocystis jirovecii Pneumonia Amongst the Non-HIV Immunosuppressed [PDF]

, 2015
INTRODUCTION Fungal Pneumonia caused by Pnemocystis Jirovecci (PCP) has long been associated with morbidity and mortality in HIV-positive patients.
Ganesh, MD, Anusha, Jones, MD, Zachary
core   +2 more sources

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

pneumonia in a healthy immunocompetent patient: A case report and literature review

SAGE Open Medical Case Reports
Pneumocystis jirovecii pneumonia, typically an opportunistic infection, is commonly associated with risk factors such as low CD4+ lymphocyte count, underlying malignancies, organ transplantation, or immunosuppressive medications.
Houda Rouis, Chirine Moussa, Yoldez Houcine, Ines Zendah, Hamida Kwas, Habib Ghedira, Sonia Maâlej   +6 more
doaj   +1 more source