Results 71 to 80 of about 28,560 (247)

Rapid Diagnosis of Pneumocystis jirovecii Pneumonia and Respiratory Tract Colonization by Next-Generation Sequencing

Mycopathologia
To describe the epidemiology of Pneumocystis jirovecii pneumonia and colonization diagnosed by next-generation sequencing (NGS) and explore the usefulness of the number of P. jirovecii sequence reads for the diagnosis of P. jirovecii pneumonia.
F. Xing, Chaowen Deng, Zhendong Luo, Shan Zou, Min Liu, Haiyan Ye, Linlin Sun, Chi-Ching Tsang, S. K. Lo, S. Lau, P. C. Woo   +10 more
semanticscholar   +1 more source

Myeloablative Busulfan, Fludarabine and Melphalan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Childhood Myeloid Malignancy

Asia-Pacific Journal of Clinical Oncology, EarlyView.
We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija, Fiona Kerr, Hazel Gough, Johnathan Soggee, Laurence C. Cheung, Rishi S. Kotecha, Shanti Ramachandran   +6 more
wiley   +1 more source

From a novel pathogenic SAMD9L variant to cohort‐wide insights: Whole‐genome sequencing highlights somatic genetic rescue and phenotypic heterogeneity

British Journal of Haematology, EarlyView.
Summary Germline gain‐of‐function variants in sterile alpha motif domain–containing 9‐like (SAMD9L), located on chromosome 7q, cause a multisystem disorder characterized by bone marrow failure, immunodeficiency and variable neurological involvement. Disease evolution is frequently shaped by somatic genetic rescue (SGR), most commonly through monosomy 7,
Hadjer Dellal, Roman Klifa, Lise Larcher, Marie Passet, Tristan Celse, Laetitia Gouas, Maud Tusseau, AURAGEN Consortium, Alexis Praga, Virginie Bernard, Mathieu Fusaro   +10 more
wiley   +1 more source

Computed tomography-based radiomics improves non-invasive diagnosis of Pneumocystis jirovecii pneumonia in non-HIV patients: a retrospective study

BMC Pulmonary Medicine
Background Pneumocystis jirovecii pneumonia (PCP) could be fatal to patients without human immunodeficiency virus (HIV) infection. Current diagnostic methods are either invasive or inaccurate.
Hang Yu, Zhen Yang, Yuanhui Wei, Wenjia Shi, Minghui Zhu, Lu Liu, Miaoyu Wang, Yueming Wang, Qiang Zhu, Zhixin Liang, Wei Zhao, Liang-an Chen   +11 more
semanticscholar   +1 more source

Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age

Journal of Fungi, 2021
Few data are available in the literature regarding Pneumocystis jirovecii infection in children under 3 years old. This retrospective cohort study aimed to describe medically relevant information among them.
Estelle Menu, Jean-Sélim Driouich, Léa Luciani, Aurélie Morand, Stéphane Ranque, Coralie L’Ollivier   +5 more
doaj   +1 more source

An Update on Invasive Fungal Infections in Solid Organ Transplant Recipients

Transplant Infectious Disease, EarlyView.
ABSTRACT Invasive fungal infections (IFI) remain a significant infection‐related complication in solid organ transplant recipients (SOTRs), the incidence of which has not changed overtime. With a focus on studies and data published after 2019, this narrative review provides an update on the epidemiology and prevention of IFIs in SOTRs and highlights ...
Tina Marinelli, Shahid Husain
wiley   +1 more source

Development of a clinical risk score for the prediction of Pneumocystis jirovecii pneumonia in hospitalised patients

BMC Infectious Diseases
The performance and availability of invasive and non-invasive investigations for the diagnosis of Pneumocystis jirovecii pneumonia (PCP) vary across clinical settings.
B. Mappin-Kasirer, O. Del Corpo, M. Gingras, Aaron Hass, J. Hsu, Cecilia Costiniuk, Nicole Ezer, R. Fraser, Todd C. Lee, Emily G. McDonald   +9 more
semanticscholar   +1 more source

Diagnosing Pneumocystis jirovecii pneumonia: A review of current methods and novel approaches.

Medical Mycology, 2020
Pneumocystis jirovecii can cause life-threatening pneumonia in immunocompromised patients. Traditional diagnostic testing has relied on staining and direct visualization of the life-forms in bronchoalveolar lavage fluid.
M. Bateman, R. Oladele, J. Kolls
semanticscholar   +1 more source

Pneumocystis Jirovecii Pneumonia Diagnosis via Metagenomic Next-Generation Sequencing

Frontiers in Medicine, 2022
The incidence of non-HIV-infected Pneumocystis Jirovecii Pneumonia (PJP) is increasing. The prognosis for non-HIV PJP is poor and diagnostic tests are of lower sensitivity in non-HIV patients.
Xiaoxiao Lu, Jianhui Zhang, Wen-tao Ma, L. Xing, H. Ning, Mengying Yao   +5 more
semanticscholar   +1 more source

Bridging the Gap Between General and Transplant Infectious Disease Practice

Transplant Infectious Disease, EarlyView.
ABSTRACT The population of iatrogenic immunocompromised individuals is steadily rising as we continue to improve in our ability to manage diseases, including cancer, autoimmune disease, and end‐organ dysfunction, with increasing access to novel agents and transplantation.
Jeremey Walker, Emily Eichenberger, Steven Pergam, Maricar Malinis, Andrea J. Zimmer   +4 more
wiley   +1 more source