Results 61 to 70 of about 191,871 (207)

Repeated Response to Daratumumab in Refractory MGUS‐Associated Pure Red Cell Aplasia Persisting After Allogeneic Transplantation: A Case Report

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Pure red cell aplasia (PRCA) is usually managed as a disorder driven predominantly by cellular immune mechanisms, but plasma cell‐directed therapy may be relevant in selected cases associated with monoclonal gammopathy. We report a case of refractory PRCA associated with IgG‐kappa monoclonal gammopathy of undetermined significance (MGUS). A 64‐
Kyoko Yoshihara, Toshimitsu Matsui, Ikuo Matsuda, Mami Samori, Yoshiyuki Fujita, Saki Takahashi, Fuyuki Yamagata, Nobuto Utsunomiya, Chisato Ohe, Satoshi Yoshihara   +9 more
wiley   +1 more source

Pneumocystis Pneumonia During Medicamentous Treatment of Cushing’s Syndrome – A Description of Two Cases

Acta Medica, 2011
Only a few cases of pneumocystis pneumonia (PCP) in Cushing’s syndrome have been published in the literature so far. In the majority of these patients, the pneumonia occurred after reduction of the hypercortisolism with medicamentous treatment. We report
Filip Gabalec, Alžběta Zavřelová, Eduard Havel, Jaroslav Cerman, jr., Jakub Radocha, Ioannis Svilias, Jan Čáp   +6 more
doaj   +1 more source

Pneumocystis jirovecii pneumonia in a non-small cell lung cancer patient on chemoradiotherapy: A case report

Saudi Journal of Medicine and Medical Sciences, 2020
Pneumocystis jirovecii pneumonia is a very uncommon complication in lung cancer patients. We report the case of a 59-year-old, Stage IIIB non-small cell lung cancer (epidermoid) patient who was receiving concurrent chemotherapy scheme (cisplatin ...
Kevin Doello, Víctor Amezcua, Javier García, Javier Valdivia   +3 more
doaj   +1 more source

The Power of Hematopoietic Stem Cell Transplantation (HSCT): A Curative Approach for Diffuse Large B‐Cell Lymphoma (DLBCL) Incidentally Detected in a SCID Baby

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Lymphoma is a rare complication of X‐linked severe combined immunodeficiency (X‐SCID) caused by IL2RG deficiency. We report an infant with IL2RG‐SCID who developed diffuse large B‐cell lymphoma (DLBCL) during pretransplant evaluation. A male infant with T−B+ SCID was diagnosed at 1 month of age and referred for hematopoietic stem cell ...
Burcu Sarıgül Cimi, Sule Haskologlu, Candan Islamoglu, Gokcan Ozturk, Nazlı Deveci, Hasret Erkmen, Selin Sevinc, Can Akal, Seda Kaynak Sahap, Sonay Özdemir, Suat Fitoz, Isınsu Kuzu, Emel Unal, Nurdan Tacyıldız, Figen Dogu, Aydan Ikinciogullari   +15 more
wiley   +1 more source

All‐Oral PI3Kδ and HDAC Inhibition with Parsaclisib Plus Chidamide and Step‐Down Maintenance in Relapsed or Refractory Peripheral T‐Cell Lymphoma: A Phase Ib Trial

MedComm, Volume 7, Issue 10, October 2026.
ABSTRACT Single‐agent targeted therapies for relapsed or refractory peripheral T‐cell lymphoma (R/R peripheral T‐cell lymphoma [PTCL]) produce modest, short‐lived responses, underscoring the need for tolerable, chemotherapy‐free combinations. In an open‐label, single‐arm Phase Ib trial at two tertiary hospitals, we evaluated parsaclisib plus chidamide ...
Xufeng Luo, Zheng Yan, Wei Fang, Hanchi Duan, Qiuyu Zhang, Haiying Wang, Shuna Yao, Jiuyang Zhang, Yiping Jin, Wenyong Li, Xiaolu Teng, Lina Zhang, Lijie Liang, Quande Lin, Ping Wang, Haoran Si, Jinxin Miao, Wenping Zhou, Zhihua Yao, You‐Wen He, Qingxin Xia, Yanyan Liu   +21 more
wiley   +1 more source

Pneumocystis colonisation is common among hospitalised HIV infected patients with non-Pneumocystis pneumonia

, 2008
Background:When Pneumocystis DNA is recovered from respiratory specimens of patients without Pneumocystis pneumonia (PCP), patients are said to be colonised with Pneumocystis, although the significance of this state is unknown. Understanding risk factors
Welsh, D A, Beard, C B, Charbonnet, D, Swartzman, A, Morris, A, Davis, J L, Crothers, K, Huang, L, Jones, J L, Lawrence, G G, Fox, M R   +10 more
core   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source

Immune responses of different hosts to Pneumocystis infection

European Respiratory Review
Pneumocystis pneumonia constitutes a critical life-threatening opportunistic infection, where the host's immune response plays a central role in its pathogenesis.
Jun Li, Xiangdong Mu, Haichao Li, Xinmin Liu   +3 more
doaj   +1 more source

Mixed Invasive Aspergillus–Mucorales Pulmonary Coinfection in a Diabetic Patient: An Uncommon Dual Fungal Pneumonia and Literature Review

Respirology Case Reports, Volume 14, Issue 10, October 2026.
Our case describes a rare lung co‐infection caused by Aspergillus and Mucorales in a 61‐year‐old man with uncontrolled diabetes and chronic kidney disease. The diagnosis was made by BAL PCR and biopsy. Despite antifungal treatment, the patient worsened and died.
Vinay Venugopal, Saurabh Karmakar, Abdul Raouf Wani, Akshita Gupta, Gaurav Kumar Singh, Vijay Kumar, Shubhendu Mishra, Alpana Srivastava   +7 more
wiley   +1 more source