Results 21 to 30 of about 3,636 (153)

Establishment and validation of a high‐throughput micro‐neutralization assay for respiratory syncytial virus (subtypes A and B)

Journal of Medical Virology, Volume 95, Issue 7, July 2023., 2023
Abstract The validation of a bioanalytical method allows us to determine its validity for a designated purpose and to guarantee the reliability of its analytical results. The virus neutralization assay has proved to be suitable for the detection and quantification of specific serum‐neutralizing antibodies against respiratory syncytial virus subtypes A ...
Carolina Bonifazi, Claudia Maria Trombetta, Irene Barneschi, Simona Latanza, Sara Leopoldi, Linda Benincasa, Margherita Leonardi, Claudia Semplici, Pietro Piu, Serena Marchi, Emanuele Montomoli, Alessandro Manenti   +11 more
wiley   +1 more source

Ausência de anticorpos contra o vírus da síndrome da cabeça inchada em frangos de corte no Planalto Médio do Rio Grande do Sul, Brasil Absence of antibodies to the swollen head syndrome virus in broiler chickens from the Planalto Médio, RS, Brazil

Ciência Rural, 2004
Com o objetivo de determinar a prevalência de anticorpos contra o pneumovírus aviário, foram coletadas 960 amostras de soro sangüíneo de 48 lotes de frangos de corte (20 amostras/lote).
Loreni Boaro, Luiz Carlos Kreutz, Rosangela Poletto, Mauricio Uonfruhauf   +3 more
doaj   +1 more source

A little less aggregation a little more replication: Viral manipulation of stress granules

WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023
Viruses depend entirely on host machinery and therefore aim to conquer the host and defeat its defenses to co‐opt its resources for its own replication. Improved understanding of how viruses counteract host immune responses such as stress granule assembly, detailed here, will inform future antiviral therapeutic strategies.
Matthew J. Brownsword, Nicolas Locker
wiley   +1 more source

Nutraceuticals and COVID‐19: A mechanistic approach toward attenuating the disease complications

Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022
Abstract Nutraceuticals have emerged as potential compounds to attenuate the COVID‐19 complications. Precisely, these food additives strengthen the overall COVID treatment and enhance the immunity of a person. Such compounds have been used at a large scale, in almost every household due to their better affordability and easy access.
Keshav Raj Paudel, Vyoma Patel, Sukriti Vishwas, Saurabh Gupta, Sumit Sharma, Yinghan Chan, Niraj Kumar Jha, Jesus Shrestha, Mohammad Imran, Nisha Panth, Shakti Dhar Shukla, Saurav Kumar Jha, Hari Prasad Devkota, Majid Ebrahimi Warkiani, Sachin Kumar Singh, Md Khadem Ali, Gaurav Gupta, Dinesh Kumar Chellappan, Philip M. Hansbro, Kamal Dua   +19 more
wiley   +1 more source

Imaging analysis reveals budding of filamentous human metapneumovirus virions and direct transfer of inclusion bodies through intercellular extensions

mBio, 2023
Human metapneumovirus (HMPV) can spread between cells through budding of virus particles or direct cell-to-cell spread. A network of budding filaments and intercellular extensions forms in HMPV-infected cells; however, the involvement of these structures
Farah El Najjar, Santiago Restrepo Castillo, Carole L. Moncman, Cheng-Yu Wu, Eduardo Isla, A. Catalina Velez Ortega, Gregory I. Frolenkov, Nicolas Cifuentes-Munoz, Rebecca Ellis Dutch   +8 more
doaj   +1 more source

Pediatric burden and seasonality of human metapneumovirus over 5 years in Managua, Nicaragua

Influenza and Other Respiratory Viruses, Volume 16, Issue 6, Page 1112-1121, November 2022., 2022
Abstract Background Human metapneumovirus (hMPV) is an important cause of pediatric respiratory infection. We leveraged the Nicaraguan Pediatric Influenza Cohort Study (NPICS) to assess the burden and seasonality of symptomatic hMPV infection in children. Methods NPICS is an ongoing prospective study of children in Managua, Nicaragua.
Kathryn Hacker, Guillermina Kuan, Nivea Vydiswaran, Gerardo Chowell‐Puente, Mayuri Patel, Nery Sanchez, Roger Lopez, Sergio Ojeda, Brenda Lopez, Jarrod Mousa, Hannah E. Maier, Angel Balmaseda, Aubree Gordon   +12 more
wiley   +1 more source

A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis

Viruses, 2020
Respiratory syncytial virus (RSV) infection is associated with oxidative lung injury, decreased levels of antioxidant enzymes (AOEs), and the degradation of the transcription factor NF-E2-related factor 2 (NRF2), a master regulator of AOE expression ...
Jeffrey M. Chambliss, Maria Ansar, John P. Kelley, Heidi Spratt, Roberto P. Garofalo, Antonella Casola   +5 more
doaj   +1 more source

First demonstration of the circulation of a pneumovirus in French pigs by detection of anti-swine orthopneumovirus nucleoprotein antibodies

Veterinary Research, 2018
The presence of pneumoviruses in pigs is poorly documented. In this study, we used the published sequence of the nucleoprotein (N) of the recently identified Swine Orthopneumovirus (SOV) to express and purify SOV N as a recombinant protein in Escherichia
Charles-Adrien Richard, Caroline Hervet, Déborah Ménard, Irina Gutsche, Valérie Normand, Fanny Renois, François Meurens, Jean-François Eléouët   +7 more
doaj   +1 more source

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier

mBio, 2021
Multiple enveloped RNA viruses of the family Paramyxoviridae and Pneumoviridae, like measles virus (MeV), Nipah virus (NiV), canine distemper virus (CDV), or respiratory syncytial virus (RSV), are of high clinical relevance.
Neeta Shrestha, Flavio Max Gall, Cyrille Mathieu, Melanie Michaela Hierweger, Melanie Brügger, Marco P. Alves, Jonathan Vesin, Damiano Banfi, David Kalbermatter, Branka Horvat, Marc Chambon, Gerardo Turcatti, Dimitrios Fotiadis, Rainer Riedl, Philippe Plattet   +14 more
doaj   +1 more source

Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies

mBio, 2022
Human metapneumovirus (HMPV) inclusion bodies (IBs) are dynamic structures required for efficient viral replication and transcription. The minimum components needed to form IB-like structures in cells are the nucleoprotein (N) and the tetrameric ...
Kerri Beth Boggs, Kearstin Edmonds, Nicolas Cifuentes-Munoz, Farah El Najjar, Conny Ossandón, McKenna Roe, Chao Wu, Carole L. Moncman, Trevor P. Creamer, Gaya K. Amarasinghe, Daisy W. Leung, Rebecca Ellis Dutch   +11 more
doaj   +1 more source